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[1]伍麗娟,倪許玲,陳心蓓,等.甘油三酯-葡萄糖指數(shù)聯(lián)合內(nèi)臟脂肪面積檢測對糖尿病前期和糖尿病的預(yù)測價(jià)值[J].福建醫(yī)藥雜志,2025,47(03):5-11.[doi:10.20148/j.fmj.2025.03.002]
　WU Lijuan,NI Xuling,CHEN Xinbei,et al.Predictive value of detection of triglyceride-glucose index combined with visceral fat area in prediabetes and diabetes[J].FUJIAN MEDICAL JOURNAL,2025,47(03):5-11.[doi:10.20148/j.fmj.2025.03.002]
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甘油三酯-葡萄糖指數(shù)聯(lián)合內(nèi)臟脂肪面積檢測對糖尿病前期和糖尿病的預(yù)測價(jià)值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期數(shù):
2025年03期
頁碼:
5-11
欄目:
臨床研究
出版日期:
2025-03-20

文章信息/Info

Title:
Predictive value of detection of triglyceride-glucose index combined with visceral fat area in prediabetes and diabetes
文章編號:
1002-2600(2025)03-0005-07
作者:
伍麗娟1; 倪許玲1; 陳心蓓1; 葉金連1; 尹蓮花1; 2
1 福建中醫(yī)藥大學(xué)附屬第二人民醫(yī)院,福州 350003; 2 福建中醫(yī)藥大學(xué)康復(fù)技術(shù)省部共建協(xié)同創(chuàng)新中心,福州 350108
Author(s):
WU Lijuan1;  NI Xuling1;  CHEN Xinbei1;  YE Jinlian1;  YIN Lianhua1; 2
1 The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350003, China; 2 Rehabilitation technology innovation center by joint collaboration of education and Fujian Province, Fujian University of traditional Chinese Medicine, Fuzhou, Fujian 350108, China
關(guān)鍵詞:
糖尿病前期;  糖尿病;  甘油三酯-葡萄糖指數(shù);  內(nèi)臟脂肪面積
Keywords:
prediabetes;  diabetes;  triglyceride-glucose index;  visceral fat area
分類號:
R587.1
DOI:
10.20148/j.fmj.2025.03.002
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討甘油三酯-葡萄糖指數(shù)(TyG)、低密度脂蛋白膽固醇與高密度脂蛋白膽固醇的比值(LDL-C/HDL-C)及內(nèi)臟脂肪面積(VFA)檢測對糖尿病前期和糖尿病的預(yù)測價(jià)值。方法 回顧性分析于福建中醫(yī)藥大學(xué)附屬第二人民醫(yī)院健康管理中心(治未病)體檢的255名受試者,按糖尿病前期和糖尿病診斷標(biāo)準(zhǔn)分為糖尿病前期組(n=100)、糖尿病組(n=79)、血糖正常組(n=76)。兩兩比較3組人群的理化指標(biāo),主要包括TG、TC、LDL-C、HDL-C、TyG、LDL-C/HDL-C、體重、BMI、脂肪量、肌肉量、體脂肪量(BF)、蛋白質(zhì)、VFA、皮下脂肪含量(SFC)等,采用多因素 logistic 回歸分析糖尿病前期和糖尿病的影響因素,使用受試者工作特征(ROC)曲線評估TyG、VFA以及TyG聯(lián)合VFA對糖尿病前期和糖尿病的預(yù)測價(jià)值。結(jié)果 糖尿病前期組和糖尿病組的TG、LDL-C、TyG、LDL-C/HDL-C均高于血糖正常組,HDL-C低于血糖正常組; 糖尿病組的TyG高于糖尿病前期組,HDL-C低于糖尿病前期組(均P<0.05)。糖尿病前期組的體重、BMI、脂肪量、身體水分、BF、VFA、VFC、SFC高于血糖正常組; 糖尿病組的體重、BMI、脂肪量、BF、VFA、VFC、浮腫指數(shù)均高于血糖正常組(均P<0.05)。TyG、VFA是糖尿病前期和糖尿病的影響因素(P<0.05),LDL-C/HDL-C不是糖尿病前期和糖尿病的影響因素(P>0.05)。對于糖尿病前期,TyG的AUC為0.719,最佳切點(diǎn)為7.225,VFA的AUC為0.667,最佳切點(diǎn)為53.5,TyG+VFA的AUC為0.743; 對于糖尿病,TyG的AUC為0.817,最佳切點(diǎn)為7.218,VFA的AUC為0.683,最佳切點(diǎn)61.75,TyG+VFA的AUC為0.822。結(jié)論 TyG、VFA是糖尿病前期和糖尿病的影響因素,兩者聯(lián)合檢測對糖尿病前期和糖尿病具有更優(yōu)的預(yù)測價(jià)值。
Abstract:
Objective To explore the predictive value of the triglyceride-glucose index(TyG), the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol(LDL-C/HDL-C), and visceral fat area(VFA)for prediabetes and diabetes. Methods A retrospective analysis was conducted on 255 subjects who underwent physical examination at the Health Management Center(Treat Before Illness)of the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine. They were divided into prediabetes group(n=100), diabetes group(n=79), and normal glucose group(n=76),according to the diagnostic criteria for prediabetes and diabetes. The physical and chemical indicators of the three groups were compared, including TG, TC, LDL-C, HDL-C, TyG, LDL-C/HDL-C, weight, BMI, fat mass, muscle mass, BF, protein, VFA, SFC, etc. Multiple factor logistic regression analysis was used to analyze the influencing factors of prediabetes and diabetes, and the receiver operating characteristic(ROC)curve was used to evaluate the predictive value of TyG, VFA, and the combination of TyG and VFA for prediabetes and diabetes. Results The levels of TG, LDL-C, TyG, and LDL-C/HDL-C in the prediabetes group and diabetes group were higher than those in the normal glucose group, while HDL-C was lower than that in the normal glucose group(P<0.05). The TyG in the diabetes group was higher than that in the prediabetes group, and HDL-C was lower than that in the prediabetes group(P<0.05). The weight, BMI, fat mass, body water, BF, VFA, VFC, and SFC in the prediabetes group were higher than those in the normal glucose group; the weight, BMI, fat mass, BF, VFA, VFC, and edema index in the diabetes group were higher than those in the normal glucose group(all P<0.05). TyG and VFA were influence factors for prediabetes and diabetes(P<0.05), LDL-C and HDL-C were not influence factors for prediabetes and diabetes(P>0.05). For prediabetes, the AUC of TyG was 0.719, the optimal cut-off was 7.225, the AUC of VFA was 0.667, the optimal cut-off was 53.5, and the AUC of TyG and VFA was 0.743; for diabetes, the AUC of TyG was 0.817, the optimal cut-off was 7.218, the AUC of VFA was 0.683, the optimal cut-off was 61.75, and the AUC of TyG and VFA was 0.822. Conclusion TyG and VFA are influence factors for prediabetes and diabetes, and the combined detection has better predictive value for prediabetes and diabetes.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省衛(wèi)健委青年科研課題項(xiàng)目(2021QNB010); 福建中醫(yī)藥大學(xué)康復(fù)技術(shù)省部共建協(xié)同創(chuàng)新中心(X2022011-協(xié)同)
通信作者:尹蓮花,Email:[email protected]
更新日期/Last Update: 2025-03-20