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[1]宋立罡,許尚文.海馬體積自動分割在內側顳葉癲癇中的價值[J].福建醫(yī)藥雜志,2025,47(03):1-4.[doi:10.20148/j.fmj.2025.03.001]
　SONG Ligang,XU Shangwen.The value of automatic segmentation of hippocampal volume in medial temporal lobe epilepsy[J].FUJIAN MEDICAL JOURNAL,2025,47(03):1-4.[doi:10.20148/j.fmj.2025.03.001]
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海馬體積自動分割在內側顳葉癲癇中的價值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期數:
2025年03期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2025-03-20

文章信息/Info

Title:
The value of automatic segmentation of hippocampal volume in medial temporal lobe epilepsy
文章編號:
1002-2600(2025)03-0001-04
作者:
宋立罡; 許尚文
福建中醫(yī)藥大學福總教學醫(yī)院(第九〇〇醫(yī)院),福州 350025
Author(s):
SONG Ligang;  XU Shangwen
Fuzong Teaching Hospital of Fujian University of Traditional Chinese Medicine(900th Hospital), Fuzhou, Fujian 350025, China
關鍵詞:
內側顳葉癲癇;  海馬亞區(qū);  磁共振成像;  自動腦分割
Keywords:
medial temporal lobe epilepsy;  hippocampal subregions;  MRI;  automatic brain segmentation
分類號:
R742.1
DOI:
10.20148/j.fmj.2025.03.001
文獻標志碼:
B
摘要:
目的 通過表面結構分割技術測量海馬亞區(qū)體積,并對比內側顳葉癲癇(MTLE)患者與健康人群的海馬亞區(qū)體積差異,以評估亞區(qū)體積特征對癲癇預后的價值。方法 基于中國人民解放軍聯(lián)勤保障部隊第九〇〇醫(yī)院癲癇數據庫搜集2011年1月至2024年12月經臨床診斷為顳葉癲癇的患者,根據納排標準最終納入患者127例、健康對照志愿者98例的MRI資料,所有受試者均在3.0T磁共振上采集圖像,利用uAI Discover-Brain即NR腦結構智能分析系統(tǒng)(20240430-release-hotx4)自動分割各腦區(qū)并自動測量各腦區(qū)的體積。結果 MTLE患者在雙側海馬前下托、旁下托、下托、CA1區(qū)、CA3區(qū)、CA4區(qū)、DG、海馬分子層、海馬尾、海馬裂(P<0.001)、右海馬杏仁核過渡區(qū)(P=0.021)、左海馬傘(P<0.001)、右海馬傘(P=0.008)等多個亞區(qū)較健康對照組出現萎縮。發(fā)病年齡、癲癇持續(xù)時間、是否發(fā)生過腦膜炎、腦外傷及高熱驚厥,均非預后結局的影響因素(P>0.05)。右側MTLE 患者預后與左海馬傘體積呈正相關(P=0.002),左側MTLE患者和同側海馬總體積(P=0.002)、內嗅皮質(P=0.04)、雙側海馬旁回體積相關(左側P=0.009、右側P=0.013)相關。結論 MTLE患者海馬總體積、海馬傘、內嗅皮質及雙側海馬旁回體積與預后結局相關,且左右側癲癇患者的亞區(qū)改變不同,說明識別海馬亞區(qū)的萎縮,可以更好地預測患者的預后。
Abstract:
Objective By measuring the hippocampal subregion volumes with surface structure segmentation technique and comparing hippocampal subregion volume differences between patients with medial temporal lobe epilepsy and the healthy population, the research aims to evaluate the value of subregion volume characteristics for the prognosis of epilepsy. Methods We collected data from patients diagnosed with temporal lobe epilepsy(TLE)from January 2011 to December 2024 based on the epilepsy database of The 900th Hospital of Joint Logistic Support Force, PLA. A total of 127 patients and 98 healthy control vo-lunteers were included according to the inclusion and exclusion criteria, and their MRI data were analyzed. All subjects underwent imaging on a 3.0 T magnetic resonance scanner. The uAI Discover-Brain, an NR brain structure intelligent analysis system(20240430-release-hotx4), was used to automatically segment and measure the volumes of various brain regions. Results Patients with mesial temporal lobe epilepsy(MTLE)exhibited atrophy in multiple subregions compared with healthy controls, including the bilateral hippocampal presubiculum, parasubiculum, subiculum, CA1, CA3, CA4, dentate gyrus(DG), hippocampal molecular layer, hippocampal tail, and hippocampal fissure(P<0.001), the right hippocampal-amygdaloid transition area(P=0.021), the left hippocampal fimbria(P<0.001), and the right hippocampal fimbria(P=0.008).The duration of epilepsy,age of onset,and medical history of febrile seizures,meningitis,or traumatic brain injury were not associated with the prognosis outcomes(P>0.05).In patients with right MTLE, prognosis was positively correlated with the volume of the left hippocampal fimbria(P=0.002). In patients with left MTLE, prognosis was correlated with the ipsilateral hippocampal total volume(P=0.002), entorhinal cortex(P=0.04), and bilateral parahippocampal gyrus volume(left P=0.009, right P=0.013). Conclusion The prognosis of MTLE patients is correlated with total hippocampal volume, hippocampal fimbria, entorhinal cortex, and the volume of the bilateral parahippocampal gyrus. Moreover, the changes in subregions differ between patients with left-sided and right-sided epilepsy. This suggests that identifying atrophy in hippocampal subregionscan better predict patient outcomes.

參考文獻/References:

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備注/Memo

備注/Memo:
基金項目:福建省自然科學基金(2023Y0066); 福建省科技廳科技創(chuàng)新聯(lián)合資金項目(2024Y9647)
通信作者:許尚文,Email:[email protected]
更新日期/Last Update: 2025-03-20