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[1]黃舒燕,黃衛(wèi)東,蔡蕾,等.重度痤瘡患者皮膚菌群多樣性研究[J].福建醫(yī)藥雜志,2025,47(02):5-8.[doi:10.20148/j.fmj.2025.02.002]
　HUANG Shuyan,HUANG Weidong,CAI Lei,et al.Study of skin microbiota diversity in patients with severe acne[J].FUJIAN MEDICAL JOURNAL,2025,47(02):5-8.[doi:10.20148/j.fmj.2025.02.002]
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重度痤瘡患者皮膚菌群多樣性研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期數(shù):
2025年02期
頁碼:
5-8
欄目:
臨床研究
出版日期:
2025-02-20

文章信息/Info

Title:
Study of skin microbiota diversity in patients with severe acne
文章編號:
1002-2600(2025)02-0005-04
作者:
黃舒燕; 黃衛(wèi)東; 蔡蕾; 黃劍清; 雷小英; 郭宏恩; 張雪梅
福建省福州市第一總醫(yī)院皮膚病防治院皮膚科,福州 350025
Author(s):
HUANG Shuyan;  HUANG Weidong;  CAI Lei;  HUANG Jianqing;  LEI Xiaoying;  GUO Hongen;  ZHANG Xuemei
Department of Dermatology,Dermatology Hospital of Fuzhou,Fuzhou,Fujian 350025,China
關鍵詞:
重度痤瘡;  細菌;  真菌;  多樣性
Keywords:
severe acne;  bacteria;  fungi;  diversity
分類號:
R758.73
DOI:
10.20148/j.fmj.2025.02.002
文獻標志碼:
B
摘要:
目的 探討重度痤瘡患者皮損內微生物菌群的多樣性。方法 選擇福州市第一總醫(yī)院皮膚病防治院皮膚科接診的30例重度痤瘡患者作為觀察組,20例正常健康人作為對照組,利用細菌16S核糖體DNA(16S rDNA)和真菌內轉錄間隔區(qū)1(Internal Transcribed Spacer 1,ITS1)擴增子測序技術,檢測痤瘡患者皮損內及正常人面部皮膚的細菌和真菌群落結構,分析兩組的物種多樣性。結果 觀察組的細菌ace指數(shù)、chao指數(shù)高于對照組,差異有統(tǒng)計學意義(P<0.001),表明細菌總量明顯增多; 同時,與對照組相比,shannon指數(shù)降低,差異有統(tǒng)計學意義(P<0.001),simpson指數(shù)升高,差異有統(tǒng)計學意義(P<0.001),且β多樣性分析差異有統(tǒng)計學意義(P=0.001),提示痤瘡皮損內細菌物種的集中度高、多樣性較低,這與丙酸桿菌屬顯著性上升有關,而且痤瘡丙酸桿菌明顯升高。觀察組的真菌ace指數(shù)和chao指數(shù)上升,差異有統(tǒng)計學意義(P<0.001),這主要與馬拉色菌屬豐度上升有關。結論 通過對比重度痤瘡患者與正常對照組的皮膚菌群,發(fā)現(xiàn)兩組在菌群的組成、豐富度和多樣性上差異有統(tǒng)計學意義,為深入了解重度痤瘡的發(fā)病機制提供參考,也為重度痤瘡的治療提供了新的研究方向。
Abstract:
Objective To investigate the skin microbiota species diversity in patients with severe acne. Methods Thirty patients with severe acne as the observation group and 20 healthy individuals as the control group were collected from Department of Dermatology, Dermatology Hospital of Fuzhou. The bacterial 16S ribosomal DNA(16S rDNA)and fungal internal transcribed spacer 1(ITS1)amplicon sequencing technology was utilized to detect the bacterial and fungal community structures within the lesions of acne patients and on the facial skin of healthy individuals. The species diversity of the two groups was analyzed. Results The bacterial ace index and chao index of the observation group were higher than those of the control group, and the difference was statistically significant(P<0.001). It indicated that the total amount of bacteria increased significantly. Compared with the control group, the shannon index of the observation group decreased, and the difference was statistically significant(P<0.001), simpson index increased and the difference was statistically significant(P<0.001).There was a statistically significant difference by β diversity analysis(P=0.001). It indicated that the concentration of bacterial species in acne lesions was high and the diversity was low, which was related to the significant increase of Propionibacterium and Propionibacterium acnes. The ace index and chao index of fungi in the observation group increased, and the difference was statistically significant(P<0.001), which was mainly related to the increase of Malassezia abundance. Conclusion By comparing the skin flora of severe acne patients and normal healthy individuals, it was found that there were statistically significant differences in the composition, richness and diversity of the flora between the two groups, which provided a reference for in-depth understanding of the pathogenesis of severe acne, and also provided a new research direction for the treatment of severe acne.

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備注/Memo

備注/Memo:
基金項目:福建省衛(wèi)生健康科技計劃項目(2021QNA065)
通信作者:黃衛(wèi)東,Email:[email protected]
更新日期/Last Update: 2025-02-20