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[1]林建立,林移婷,陳耀琦,等.絕經(jīng)后骨質(zhì)疏松患者骨代謝與脂代謝的關系及血清蛋白組學研究[J].福建醫(yī)藥雜志,2025,47(02):1-4.[doi:10.20148/j.fmj.2025.02.001]
　LIN Jianli,LIN Yiting,CHEN Yaoqi,et al.Serum proteomics study on the relationship between bone metabolism and lipid metabolism in postmenopausal osteoporosis[J].FUJIAN MEDICAL JOURNAL,2025,47(02):1-4.[doi:10.20148/j.fmj.2025.02.001]
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絕經(jīng)后骨質(zhì)疏松患者骨代謝與脂代謝的關系及血清蛋白組學研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
47
期數(shù):
2025年02期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2025-02-20

文章信息/Info

Title:
Serum proteomics study on the relationship between bone metabolism and lipid metabolism in postmenopausal osteoporosis
文章編號:
1002-2600(2025)02-0001-04
作者:
林建立1; 林移婷2; 陳耀琦3; 胡張潔4; 蔡敏4
1 福州大學附屬省立醫(yī)院內(nèi)分泌科,福州 350001; 2 福建省福州市第二總醫(yī)院內(nèi)分泌科,福州 350001; 3 福州大學附屬省立醫(yī)院核醫(yī)學科,福州 350001; 4 福州大學附屬省立醫(yī)院干部特診二科,福州 350001
Author(s):
LIN Jianli1;  LIN Yiting2;  CHEN Yaoqi3;  HU Zhangjie4;  CAI Min4
1 Department of Endocrinology,Fujian Provincial Hospital Affiliated to Fuzhou University,Fuzhou,Fujian 350001,China; 2 Department of Endocrinology,Fuzhou Second General Hospital,Fuzhou,Fujian 350001,China; 3 Department of Nuclear Medicine,Fujian Provincial Hospital Affiliated to Fuzhou University,Fuzhou,Fujian 350001,China; 4 Department of Special Outpatient Services for Cadres,Fujian Provincial Hospital Affiliated to Fuzhou University,Fuzhou,Fujian 350001,China
關鍵詞:
絕經(jīng)后骨質(zhì)疏松癥;  骨代謝;  脂代謝;  血清蛋白質(zhì)組學
Keywords:
postmenopausal osteoporosis;  bone metabolism;  lipid metabolism;  serum proteomics
分類號:
R58
DOI:
10.20148/j.fmj.2025.02.001
文獻標志碼:
B
摘要:
目的 探討絕經(jīng)后骨質(zhì)疏松(PMOP)患者脂代謝與骨代謝的關系,并通過血清蛋白質(zhì)組學分析篩選相關標志物,為PMOP的診斷和治療提供新思路。方法 收集125例絕經(jīng)后患者資料,按骨密度分為骨質(zhì)疏松組(75例)和非骨質(zhì)疏松組(50例)。采集兩組各5例患者的血清進行定量蛋白質(zhì)組學分析。通過質(zhì)譜和生物信息學分析,篩選差異表達蛋白,并進行GO富集分析和PPI蛋白互作網(wǎng)絡分析。結果 骨質(zhì)疏松組的甘油三酯(TG)、低密度脂蛋白(LDL)水平和頸動脈硬化斑塊數(shù)量高于非骨質(zhì)疏松組,差異有統(tǒng)計學意義(P<0.05)。Pearson相關性分析顯示,腰椎、股骨頸和髖部骨密度(BMD)與TG、LDL和β-Ⅰ型膠原交聯(lián)C末端肽(β-CTX)呈負相關(P<0.05),頸動脈硬化斑塊數(shù)量越多,BMD越低(P<0.05)。蛋白質(zhì)組學分析篩選出30個差異表達蛋白,其中脂聯(lián)素和磷酸烯醇式丙酮酸羧激酶在骨質(zhì)疏松組中表達上調(diào)。GO富集分析顯示,差異蛋白主要富集在細胞過程、抗氧化活動、生物調(diào)節(jié)和信號傳導等。PPI網(wǎng)絡分析篩選出4個Hub基因:ADIPOQ、PCK2、CA3和CLIC1。結論 骨質(zhì)疏松組的TG、LDL和頸動脈硬化斑塊數(shù)量升高,TG、LDL與BMD呈負相關。差異蛋白Q15848和Q16882可能通過腺苷單磷酸激活蛋白激酶(AMPK)信號通路影響骨代謝和脂質(zhì)代謝,該發(fā)現(xiàn)為PMOP的診斷和治療提供了潛在生物標志物。未來研究將進一步探討其具體機制,為臨床干預提供新靶點。
Abstract:
Objective To investigate the relationship between lipid metabolism and bone metabolism in postmenopausal osteoporosis(PMOP)patients and to identify related biomarkers through serum proteomics analysis, providing new insights for the diagnosis and treatment of PMOP. Methods A total of 125 postmenopausal patients were collected and divided into osteoporosis group(75 cases)and non-osteoporosis group(50 cases)based on bone density.Serum samples from five randomly selected patients in each group were analyzed using quantitative proteomics.Differentially expressed proteins were identified through mass spectrometry and bioinformatics analysis, followed by GO enrichment analysis and PPI network analysis.Results Compared with the non-osteoporosis group, the levels of triglycerides(TG), low-density lipoprotein(LDL), and carotid atherosclerotic plaque count were significantly higher in the osteoporosis group(P<0.05).Pearson correlation analysis showed that bone mineral density(BMD)of the lumbar spine, femoral neck, and hip was negatively correlated with TG, LDL, and β-C-terminal telopeptide of type Ⅰ collagen(β-CTX)(P<0.05).Proteomics analysis identified 30 differentially expressed proteins, among which adiponectin and phosphoenolpyruvate carboxykinase were upregulated in the osteoporosis group.GO enrichment analysis indicated that these proteins were mainly involved in cellular processes, antioxidant activity, biological regulation, and signal transduction.PPI network analysis identified four hub genes: ADIPOQ, PCK2, CA3 and CLIC1.Conclusion The levels of TG, LDL, and carotid atherosclerotic plaque count are elevated in the osteoporosis group and negatively correlated with BMD.Differential proteins Q15848 and Q16882 may affect bone and lipid metabolism through the Adenosine Monophosphate Activated Protein Kinase(AMPK)signaling pathway, providing potential biomarkers for the diagnosis and treatment of PMOP.Future studies will further explore the specific mechanisms of these proteins to identify new therapeutic targets for clinical intervention.

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備注/Memo

備注/Memo:
基金項目:福建省自然科學基金項目(2016J01434)
通信作者:蔡 敏,Email: [email protected]
更新日期/Last Update: 2025-02-20