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[1]康靖,房濤,倪宇君.基于自動纖維定量技術(shù)分析孤獨癥譜系障礙患者白質(zhì)纖維束改變[J].福建醫(yī)藥雜志,2024,46(05):1-5.[doi:10.20148/j.fmj.2024.05.001]
　KANG Jing,FANG Tao,NI Yujun.Analysis of white matter fiber bundle changes in autism spectrum disorder patients based on automated fiber quantitative technology[J].FUJIAN MEDICAL JOURNAL,2024,46(05):1-5.[doi:10.20148/j.fmj.2024.05.001]
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基于自動纖維定量技術(shù)分析孤獨癥譜系障礙患者白質(zhì)纖維束改變()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年05期
頁碼:
1-5
欄目:
臨床研究
出版日期:
2024-10-15

文章信息/Info

Title:
Analysis of white matter fiber bundle changes in autism spectrum disorder patients based on automated fiber quantitative technology
文章編號:
1002-2600(2024)05-0001-05
作者:
康靖; 房濤; 倪宇君
福建省福州市第一總醫(yī)院兒童專科院區(qū)放射科,福州350001
Author(s):
KANG Jing;  FANG Tao;  NI Yujun
Department of Radiology, Fuzhou First General Hospital Pediatric Campus, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
孤獨癥譜系障礙;  彌散張量成像;  自動纖維定量技術(shù)
Keywords:
autism spectrum disorder;  diffusion tensor imaging;  automated fiber quantification
分類號:
R749.94; R445.2
DOI:
10.20148/j.fmj.2024.05.001
文獻標志碼:
A
摘要:
目的 采用自動纖維定量技術(shù)(AFQ)分析孤獨癥譜系障礙(ASD)患者大腦白質(zhì)纖維束的特征,探索其在ASD患者中的應(yīng)用價值及ASD患者白質(zhì)纖維束的改變。方法 自閉癥腦成像數(shù)據(jù)庫(ABIDE)公共數(shù)據(jù)集中Trinity Centre for Health Sciences的20名ASD患者和20名性別、年齡、慣用手與之相匹配的健康對照組均進行了磁共振彌散張量成像(DTI)掃描,采用AFQ技術(shù)自動提取大腦主要纖維束并分段,對纖維束均值和纖維束分段逐點進行組間比較,分析ASD患者白質(zhì)纖維束改變。結(jié)果(1)在纖維束平均值組間比較中,成功追蹤的18條纖維束DTI指標均值組間差異無統(tǒng)計學意義;(2)在纖維束逐點比較中,ASD纖維束在右側(cè)皮質(zhì)脊髓束(CST)、雙側(cè)上縱束(SLF)及左側(cè)弓形束(AF)與健康對照組比較,差異均有統(tǒng)計學意義[多重比較矯正(FDR)后P<0.05],表現(xiàn)為節(jié)段性的各向異性分數(shù)(FA)減低、平均擴散系數(shù)(MD)和徑向擴散系數(shù)(RD)增高。結(jié)論 AFQ可能有助于在疾病早期發(fā)現(xiàn)神經(jīng)纖維束中的細小差異; ASD患者多條神經(jīng)纖維束與正常人存在顯著差異,這些白質(zhì)纖維束的改變可能是造成ASD患者臨床表現(xiàn)復(fù)雜而多樣的基礎(chǔ)。
Abstract:
Objective To analyze the characteristics of white matter fiber tracts in the brains of patients with autism spectrum disorder(ASD)by employing automated fiber quantification(AFQ)technology, and explore its application value in identifying changes in the white matter fiber tracts of ASD patients. Methods Twenty ASD patients from the Trinity Centre for Health Sciences in the Autism Brain Imaging Data Exchange(ABIDE)public dataset and 20 healthy controls matched by gender, age, and handedness underwent magnetic resonance diffusion tensor imaging(DTI)scans. AFQ was used to automatically extract and segment the major fiber tracts of the brain, separately extract the mean of DTI parameters within each fiber tract and each segment. One-way ANOVA(Analysis of Variance)and the Mann-Whitney U test were utilized to compare the differences in the mean of DTI parameters within fiber tracts and segments between the two groups. Results(1)In the inter-group comparison of fiber tracts, no significant differences were observed in DTI parameters means of the 18 fiber tracts;(2)In the inter-group comparison of fiber tract segmentations, significant differences were found between the two groups in the right corticospinal tract(CST), bilateral superior longitudinal fasciculus(SLF), and left arcuate fasciculus(AF)(after FDR correction P<0.05), characterized by segmental reduction in fractional anisotropy(FA)values and increases in mean diffusivity(MD)values and radial diffusivity(RD)values in ASD fiber tract. However, there were no significant differences in AD values between the two groups. Conclusions AFQ may help to detect subtle differences in nerve fiber tracts at an early stage of the disease.There are significant differences in multiple nerve fiber tracts between ASD patients and normal individuals, and these changes in white matter fiber tracts may be the basis for the complex and diverse clinical manifestations in ASD patients.

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備注/Memo

備注/Memo:
基金項目:福州市臨床重點專科建設(shè)項目(20220101)
更新日期/Last Update: 2024-10-15