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[1]張良志,劉洪,楊金碩,等.針刀治療膝骨性關(guān)節(jié)炎的臨床療效及機(jī)制研究[J].福建醫(yī)藥雜志,2024,46(02):18-22.[doi:10.20148/j.fmj.2024.02.005]
　ZHANG Liangzhi,LIU Hong,YANG Jinshuo,et al.Clinical efficacy and mechanism of acupotomy in the treatment of knee osteoarthritis[J].FUJIAN MEDICAL JOURNAL,2024,46(02):18-22.[doi:10.20148/j.fmj.2024.02.005]
點(diǎn)擊復(fù)制

針刀治療膝骨性關(guān)節(jié)炎的臨床療效及機(jī)制研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年02期
頁(yè)碼:
18-22
欄目:
臨床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Clinical efficacy and mechanism of acupotomy in the treatment of knee osteoarthritis
文章編號(hào):
1002-2600(2024)02-0018-05
作者:
張良志1; 2; 劉洪1; 2; 楊金碩3; 劉晶1; 余文英2; 李陽(yáng)陽(yáng)2; 謝梓毅2; 施橙維2; 修忠標(biāo)1; 2
1 福建中醫(yī)藥大學(xué)附屬人民醫(yī)院骨傷科,福州 350004; 2 福建中醫(yī)藥大學(xué)中醫(yī)骨傷及運(yùn)動(dòng)康復(fù)教育部重點(diǎn)實(shí)驗(yàn)室,福州 350122; 3 福建中醫(yī)藥大學(xué),福州 350122
Author(s):
ZHANG Liangzhi1; 2; LIU Hong1; 2; YANG Jinshuo3; LIU Jing1; YU Wenying2; LI Yangyang2; XIE Ziyi2; SHI Chengwei2; XIU Zhongbiao1; 2
1 Department of Orthopedics-Traumatology, the Affiliated People’s Hospital,Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, China; 2 Key Laboratory of Orthopedics & Traumatology of Traditional Chinese Medicine and Rehabilitation Ministry of Education, Fujian university of TCM, Fuzhou, Fujian 350122, China; 3 Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
關(guān)鍵詞:
高通量蛋白組學(xué);  膝骨關(guān)節(jié)炎;  針刀
Keywords:
high throughput proteomics;  knee osteoarthritis;  acupotomy
分類號(hào):
R319; R733.71
DOI:
10.20148/j.fmj.2024.02.005
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 觀察針刀治療膝關(guān)節(jié)骨性關(guān)節(jié)炎臨床療效,并探討針刀治療膝骨性關(guān)節(jié)炎的機(jī)制。方法 通過(guò)招募正常人10例、膝骨性關(guān)節(jié)炎(KOA)患者40例,分為正常組、針刀組。正常組直接抽取關(guān)節(jié)積液; 針刀組予針刀治療,7 d為1個(gè)療程,持續(xù)3個(gè)療程。針刀組中隨機(jī)抽取10例在治療前、3個(gè)療程結(jié)束后抽取關(guān)節(jié)積液。對(duì)針刀治療前后股直肌剪切波成像(SWE)、視覺(jué)模擬評(píng)分法(VAS)、骨關(guān)節(jié)炎指數(shù)(WOMAC)進(jìn)行對(duì)比,以評(píng)價(jià)治療的效果。對(duì)關(guān)節(jié)液行Western blot檢測(cè)關(guān)節(jié)液中IL-1β、Caspase-1蛋白表達(dá),差異蛋白篩選和KEGG富集分析。結(jié)果 與治療前相比,治療后SWE值、VAS評(píng)分、WOMAC評(píng)分明顯下降,差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05); 治療后股直肌硬度較治療前下降。針刀能夠下調(diào)KOA患者關(guān)節(jié)液中IL-1β、Caspase-1蛋白的表達(dá),發(fā)揮抗炎、保護(hù)軟骨的作用。KEGG富集分析顯示參與KOA病變的信號(hào)通路主要為PPAR信號(hào)通路、MAPK信號(hào)通路。結(jié)論 針刀治療膝骨關(guān)節(jié)炎有較好臨床療效,同時(shí)針刀能夠通過(guò)下調(diào)軟骨相關(guān)信號(hào)通路的蛋白靶點(diǎn)的表達(dá),降低關(guān)節(jié)內(nèi)炎癥反應(yīng)。
Abstract:
Objective To observe the clinical effect of acupotomy on knee osteoarthritis and explore the mechanism of acupotomy on knee osteoarthritis.Methods Ten healthy people and forty patients with KOA were recruited and divided into normal group and acupotomy group.In the normal group, the joint effusion was extracted directly, and the acupotomy group was treated with acupotomy for 7 days, lasting for 3 courses.In the acupotomy group, 10 patients were randomly selected to extract joint effusion before treatment and after 3 courses of treatment.Shear wave elastography(SWE), Visual analogue scale(VAS)and Western Ontario and McMaster Universities(WOMAC)were compared before and after acupotomy to evaluate the therapeutic effect.The expression of IL-1β and Caspase-1 protein in joint fluid were detected by Western blot, differential protein screening and KEGG enrichment analysis.Results SWE value, VAS score and WOMAC score decreased significantly after treatment, and the differences were statistically significant(P<0.05).The hardness of the rectus femoris muscle after treatment was lower than that before treatment.Acupotomy can down-regulate the expression of IL-1β and Caspase-1 protein in joint fluid of KOA patients, and play an anti-inflammatory and protective role in cartilage.KEGG enrichment analysis showed that the signal pathways involved in KOA lesions were mainly PPAR signal pathway and MAPK signal pathway.Conclusion Acupotomy has good clinical efficacy in the treatment of knee osteoarthritis.At the same time, acupotomy can reduce the intraarticular inflammation by down-regulating the expression of protein targets in chondro-related signaling pathways.

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備注/Memo

備注/Memo:
基金項(xiàng)目:2019年度國(guó)家中醫(yī)臨床研究基地專項(xiàng)科研課題(JDZX201932)
通信作者:修忠標(biāo),Email:[email protected]
更新日期/Last Update: 2024-04-15