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[1]蘇川,齊元麟.M2型丙酮酸激酶在宮頸鱗狀細(xì)胞癌和宮頸腺癌中臨床意義的生物信息學(xué)分析[J].福建醫(yī)藥雜志,2024,46(02):1-5.[doi:10.20148/j.fmj.2024.02.001]
　SU Chuan,QI Yuanlin.Bioinformatics analysis of the clinical significance of PKM2 in cervical squamous cell carcinoma and endocervical adenocarcinoma[J].FUJIAN MEDICAL JOURNAL,2024,46(02):1-5.[doi:10.20148/j.fmj.2024.02.001]
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M2型丙酮酸激酶在宮頸鱗狀細(xì)胞癌和宮頸腺癌中臨床意義的生物信息學(xué)分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年02期
頁碼:
1-5
欄目:
臨床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Bioinformatics analysis of the clinical significance of PKM2 in cervical squamous cell carcinoma and endocervical adenocarcinoma
文章編號:
1002-2600(2024)02-0001-05
作者:
蘇川1; 齊元麟2
1 閩江師范高等專科學(xué)校,福州350109; 2 福建醫(yī)科大學(xué),福州350122
Author(s):
SU Chuan1; QI Yuanlin2
1 Minjiang Teachers College, Fuzhou, Fujian 350109, China; 2 Fujian Medical University, Fuzhou, Fujian 350122, China
關(guān)鍵詞:
M2型丙酮酸激酶;  宮頸鱗狀細(xì)胞癌和宮頸腺癌;  臨床意義;  生物信息學(xué)
Keywords:
M2 type pyruvate kinase;  cervical squamous cell carcinoma and endocervical adenocarcinoma;  clinical significance;  bioinformatics
分類號:
R319; R737.3
DOI:
10.20148/j.fmj.2024.02.001
文獻標(biāo)志碼:
A
摘要:
目的 基于生物信息學(xué)方法分析M2型丙酮酸激酶(pyruvate kinase M2,PKM2)在宮頸鱗狀細(xì)胞癌和宮頸腺癌(cervical squamous cell carcinoma and endocervical adenocarcinoma,CESC)中的臨床意義。方法 通過R軟件分析PKM2基因在CESC和正常宮頸組織中的表達差異; GEPIA平臺分析PKM2基因?qū)ESC病人總生存期(overall survival,OS)的影響; TIMER平臺驗證PKM2基因表達對CESC病人OS的影響; HPA平臺分析PKM2蛋白表達對CESC病人OS的影響; TIMER平臺分析免疫細(xì)胞浸潤水平與PKM2基因表達及病人OS的相關(guān)性。結(jié)果 CESC病人中PKM2基因和蛋白質(zhì)高表達病人的OS均劣于低表達者,CESC中PKM2基因表達還與免疫細(xì)胞浸潤水平有關(guān),而免疫細(xì)胞浸潤水平又與病人的OS有關(guān)。結(jié)論 PKM2是CESC預(yù)后的不利因素,在CESC的診斷和治療中可作為潛在的指標(biāo)和靶點。
Abstract:
Objective To explore the clinical significance of M2 type pyruvate kinase(PKM2)in cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC)based on bioinformatics method.Methods The expression differences of PKM2 gene between CESC and normal cervical tissue were analyzed using R software; the impact of PKM2 gene expression on overall survival(OS)of CESC patients was analyzed on GEPIA platform; the impact of PKM2 gene expression on the OS of CESC patients was verified on TIMER platform; the impact of PKM2 protein expression on the OS of CESC patients was analyzed on HPA platform; the correlation between immune cell infiltration levels, PKM2 gene expression, and patient OS was analyzed on TIMER platform.Results The OS of patients with high expression of PKM2 gene and protein in CESC was inferior to those with low expression, PKM2 gene expression in CESC is also related to the level of immune cell infiltration, which in turn is related to the OS of patients.Conclusion PKM2 is an unfavorable prognostic factor for CESC and can serve as a potential indicator and target in the diagnosis and treatment of CESC.

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備注/Memo

備注/Memo:
通信作者:齊元麟,Email:[email protected]
更新日期/Last Update: 2024-04-15