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[1]吳蕓,徐貽佺,林瀛.肺腺癌患者癌組織中SMC2的表達(dá)及其對(duì)預(yù)后影響的分析[J].福建醫(yī)藥雜志,2023,45(05):5-8.
　WU Yun,XU Yiquan,LIN Ying.Analysis of SMC2 expression in lung adenocarcinoma tumor tissues and its prognostic implications[J].FUJIAN MEDICAL JOURNAL,2023,45(05):5-8.
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肺腺癌患者癌組織中SMC2的表達(dá)及其對(duì)預(yù)后影響的分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年05期
頁(yè)碼:
5-8
欄目:
臨床研究
出版日期:
2023-10-15

文章信息/Info

Title:
Analysis of SMC2 expression in lung adenocarcinoma tumor tissues and its prognostic implications
文章編號(hào):
1002-2600(2023)05-0005-04
作者:
吳蕓; 徐貽佺1; 林瀛2
福建省立醫(yī)院(福州 350001)
Author(s):
WU Yun;  XU Yiquan;  LIN Ying
Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
肺腺癌;  SMC2表達(dá);  臨床預(yù)后
Keywords:
lung adenocarcinoma;  SMC2 expression;  clinical prognosis
分類號(hào):
R734.2
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討SMC2在肺腺癌中的表達(dá)情況以及其在臨床預(yù)后中的價(jià)值。方法 收集我院207例肺腺癌患者的石蠟包埋組織樣本進(jìn)行免疫組織化學(xué)分析,檢測(cè)SMC2蛋白的表達(dá)情況。利用TCGA數(shù)據(jù)庫(kù)分析肺腺癌樣本及癌旁組織SMC2 mRNA的表達(dá)數(shù)據(jù)。分析且探討SMC表達(dá)與臨床分期和生存預(yù)后的關(guān)系。結(jié)果 免疫組化分析確認(rèn),肺腺癌組織中SMC2 蛋白高表達(dá),且與腫瘤分期密切相關(guān),是不良預(yù)后的危險(xiǎn)因素。肺腺癌組織中SMC2 mRNA表達(dá)亦顯著增高且高于癌旁正常組織,并與腫瘤的TNM分期正相關(guān); Kaplan-Meier分析顯示SMC2 mRNA表達(dá)較高的患者生存期明顯較短。結(jié)論 SMC2高表達(dá)可能作為肺腺癌患者的危險(xiǎn)預(yù)測(cè)因子,為肺腺癌的診斷和治療提供了新的研究方向。
Abstract:
Objective To investigate the expression of SMC2 in lung adenocarcinoma and its clinical prognostic value.Methods Paraffin-embedded tissue samples from 207 patients with lung adenocarcinoma were collected for immunohistochemical analysis to examine the expression of SMC2 protein.The expression data of SMC2 mRNA in lung adenocarcinoma samples and adjacent normal tissues were analyzed using the TCGA database.The relationship between SMC2 expression and clinical staging as well as survival prognosis was analyzed.Results Immunohistochemical analysis confirmed the high expression of SMC2 protein in lung adenocarcinoma tissues was closely associated with tumor staging and indicated poor prognosis.Moreover, SMC2 mRNA expression was significantly elevated in lung adenocarcinoma tissues compared to adjacent normal tissues and positively correlated with the TNM staging of the tumors.Kaplan-Meier analysis demonstrated that patients with higher SMC2 mRNA expression had significantly shorter overall survival.Conclusion High expression of SMC2 may serve as a potential prognostic factor for lung adenocarcinoma patients, providing a new research direction for the diagnosis and treatment of this disease.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
1 福建省腫瘤醫(yī)院; 2 通信作者,Email: [email protected]
更新日期/Last Update: 2023-10-15