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[1]楊麗英,楊直,杜薇,等.子宮內(nèi)膜癌PPP2R5A及c-Myc表達(dá)與預(yù)后的臨床關(guān)系[J].福建醫(yī)藥雜志,2023,45(05):1-4.
　YANG Liying,YANG Zhi,DU Wei,et al.Expression of PPP2R5A and c-Myc in endometrial cancer and clinical relationship with prognosis[J].FUJIAN MEDICAL JOURNAL,2023,45(05):1-4.
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子宮內(nèi)膜癌PPP2R5A及c-Myc表達(dá)與預(yù)后的臨床關(guān)系()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年05期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2023-10-15

文章信息/Info

Title:
Expression of PPP2R5A and c-Myc in endometrial cancer and clinical relationship with prognosis
文章編號:
1002-2600(2023)05-0001-04
作者:
楊麗英; 楊直; 杜薇; 莊良武1; 高愛明; 程世越
福建中醫(yī)藥大學(xué)附屬人民醫(yī)院病理科(福州 350004)
Author(s):
YANG Liying;  YANG Zhi;  DU Wei;  ZHUANG Liangwu;  GAO Aiming;  CHENG Shiyue
Department of Pathology, People's Hospital affiliated to the Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian350004, China
關(guān)鍵詞:
子宮內(nèi)膜癌;  PPP2R5A;  c-Myc;  免疫組化
Keywords:
endometrial cancer;  PPP2R5A;  c-Myc;  immunohistochemistry
分類號:
R737.33
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討PPP2R5A與c-Myc在子宮內(nèi)膜癌(EC)中的表達(dá),確定兩者表達(dá)強(qiáng)度及其與患者預(yù)后的臨床關(guān)系。方法 運(yùn)用免疫組織化學(xué)法檢Ⅰ型和Ⅱ型子宮內(nèi)膜癌、子宮內(nèi)膜不典型增生及正常增生期各12例中子宮內(nèi)膜組織PPP2R5A與C-myc的表達(dá),分析PPP2R5A、c-Myc蛋白的表達(dá)強(qiáng)度與子宮內(nèi)膜癌臨床指標(biāo)的關(guān)系及對子宮內(nèi)膜癌預(yù)后的影響。結(jié)果 PPP2R5A在Ⅱ型子宮內(nèi)膜癌表達(dá)強(qiáng)度較其他3組高,差異有統(tǒng)計(jì)學(xué)意義(P<0.05); Ⅰ型及不典型增生表達(dá)強(qiáng)度較正常增生期子宮內(nèi)膜組織中表達(dá)稍強(qiáng),差異無統(tǒng)計(jì)學(xué)意義(P>0.05); c-Myc在Ⅱ型EC表達(dá)強(qiáng)度較其他3組強(qiáng)高,與正常增生組和不典型增生組相比,差異有統(tǒng)計(jì)學(xué)意義(P<0.05),與Ⅰ型EC相比,差異無統(tǒng)計(jì)學(xué)意義(P>0.05); Ⅰ型EC較正常增生組、不典型增生組表達(dá)高,差異有統(tǒng)計(jì)學(xué)意義(P<0.05); PPP2R5A及c-Myc在Ⅰ型和Ⅱ型子宮內(nèi)膜癌中的表達(dá)比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05); 子宮內(nèi)膜癌組織中,PPP2R5A表達(dá)與年齡、FIGO分期、淋巴脈管間隙受侵、淋巴結(jié)轉(zhuǎn)移情況比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),與組織學(xué)分級比較,差異有統(tǒng)計(jì)學(xué)意義(P<0.05); c-Myc的表達(dá)與年齡、FIGO分期比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),與組織學(xué)分級、淋巴脈管間隙受侵、淋巴結(jié)轉(zhuǎn)移情況比較,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 PPP2R5A高表達(dá)和c-Myc高表達(dá)是影響子宮內(nèi)膜癌臨床進(jìn)展和預(yù)后的獨(dú)立因素,PPP2R5A對子宮內(nèi)膜癌特別是Ⅱ型EC的預(yù)后和發(fā)展過程有一定的提示意義,c-Myc在腫瘤細(xì)胞的發(fā)生發(fā)展過程中發(fā)揮著重要作用,通過檢測PPP2R5A和c-Myc的表達(dá)能夠更加有效地評估子宮內(nèi)膜癌患者的預(yù)后。
Abstract:
Objective To investigate the expression of PPP2R5A and c-Myc in endometrial cancer(EC), and to identify the relationship between the expression of PPP2R5A and c-myc and prognosis.Methods The expression of PPP2R5A and c-myc in 12 cases of type I and 12 cases of type Ⅱ endometrial cancer, 12 cases of atypical hyperplasia of endometrium and 12 cases of normal endometrium were detected by immunohistochemistry, the relationship between the expression of PPP2R5A and c-Myc protein and the clinicopathological parameters of endometrial cancer was analyzed.Results The expression of PPP2R5A in type Ⅱ EC was stronger than that in the other three groups, and the expression of PPP2R5A in type I and atypical hyperplasia was stronger than that in normal endometrium, but there was no statistical significance; The expression of c-Myc in type Ⅱ EC was stronger than that in the other three groups, and had statistical significance compared with normal and atypical hyperplasia groups, but had no statistical significance compared with type I EC; The expression of type I EC was significantly higher than that of normal and atypical hyperplasia groups; There was no significant difference in the expression of PPP2R5A and c-Myc between Type I and Type Ⅱ endometrial cancer; The expression of PPP2R5A was not correlated with age, Figo stage, lymphatic space invasion and lymph node metastasis, there was significant correlation with histological grade; The expression of c-Myc was not correlated with age and FIGO stage, there were significant differences with histological grade, lymphatic vessel space invasion and lymph node metastasis.Conclusion The high expression of PPP2R5A and c-Myc is an independent factor affecting the clinical progression and prognosis of endometrial cancer.PPP2R5A may have some implications for the prognosis and development of endometrial cancer, especially type Ⅱ EC, c-Myc also plays an important role in the development of tumor cells,and the detection of the expression of PPP2R5A and c-Myc can more effectively evaluate the prognosis of endometrial cancer patients.

參考文獻(xiàn)/References:

[1] 李小毛,楊曉輝,葉輝霞,等.早期子宮內(nèi)膜癌患者腹水細(xì)胞學(xué)檢查陽性的危險因素及其對預(yù)后的影響[J].實(shí)用婦產(chǎn)科雜志,2015,31(8):591-595.
[2] Shi Z M,Liu Y N,Fu B,et al.Expression profile of eukaryotic translation initiation factor and matrix metalloproteinase 9 in endometrial cancer tissue[J].J Biol Regul Homeost Agents,2017,31(4):1053-1059.
[3] 康朋朋,劉洪博,張紅,等.TRβ1、β-catenin和C-myc在子宮內(nèi)膜樣腺癌組織中的表達(dá)及臨意義[J].臨床腫瘤學(xué)志,2019,24(10):903-907.
[4] Virshup D M,Shenolikar S.From promiscuity to precision: protein phosphatases get a makeover[J].Mol.Cell,2009,33(5):537-545.
[5] Remmerie M, Janssens V.PP2A:a promising biomarker and therapeutic target in endometrial cancer[J].Front Oncol,2019(9):462.
[6] Mei C,Sun Z E,Tan L M,et al.eIF3a-PPP2R5A-mediated ATM/ATR dephosphorylation is essential for irinotecan-induced DNA damage response[J].Cell Prolif,2022,55(4):e13208.
[7] Wen S Y, Li C H,Zhang Y L,et al.Rictoris an Independent prognostic factor for endometrial carcinoma[J].Int J Clin Exp Pathol,2014,7(5):2068-2078.
[8] Wang L,Jiang Q,Hua S,et al.High nuclear expression of HDGF correlates with disease progression and poor prognosis in human endometrial carcinoma[J].Dis Markers,2014,2014:298795.
[9] Nicolaije K H,Ezendam N P,Vos M C,et al.Follow-up practice in endometrial cancer and the association with patient and hospital characteristics: a study from the population-based PROFILES registry[J].Gynecol Oncol,2013,129(2):324-331.
[10] Lui G Y L,Grandori C,Kemp C J,et al.CDK12: an emerging therapeutic target for cancer[J].J Clin Pathol,2018,71(11):957-962.
[11] Liu L, Zhang J,Yang X, et al.SALL4 as an epithelial-mesenchymal transition and drug resistance inducer through the regulation of c-Myc in endometrial cancer[J].PLoS One, 2015,10(9):e0138515.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省教育廳中青年教師教育科研項(xiàng)目(科技類)(JAT190256)
1 福建中醫(yī)藥大學(xué)附屬人民醫(yī)院婦科
更新日期/Last Update: 2023-10-15