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[1]劉巖,伍林招,劉楠楠,等.3D打印技術(shù)構(gòu)建不同比例PLA/TiO2復(fù)合支架及其性能評(píng)估[J].福建醫(yī)藥雜志,2023,45(02):107-110.
　LIU Yan,WU Linzhao,LIU Nannan,et al.Construction and performance evaluation of PLA/TiO2 nanocomposite scaffolds with different proportions by 3D printing technology[J].FUJIAN MEDICAL JOURNAL,2023,45(02):107-110.
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3D打印技術(shù)構(gòu)建不同比例PLA/TiO2復(fù)合支架及其性能評(píng)估()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年02期
頁(yè)碼:
107-110
欄目:
基礎(chǔ)研究
出版日期:
2023-04-15

文章信息/Info

Title:
Construction and performance evaluation of PLA/TiO2 nanocomposite scaffolds with different proportions by 3D printing technology
文章編號(hào):
1002-2600(2023)02-0107-04
作者:
劉巖; 伍林招; 劉楠楠; 張韜
福建省福州市第二醫(yī)院骨科研究所（福州 350007）
Author(s):
LIU Yan;  WU Linzhao;  LIU Nannan;  ZHANG Tao
Department of Orthopedics Institute, Fuzhou Second Hospital, Fuzhou, Fujian 350007, China
關(guān)鍵詞:
3D打印; 聚乳酸; 納米TiO2; 復(fù)合支架; 細(xì)胞增殖
Keywords:
3D printing;  polylactic acid;  nano-TiO2;  composite scaffold;  cell proliferation
分類號(hào):
R816.8
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 利用3D打印技術(shù)構(gòu)建不同比例的聚乳酸/二氧化鈦(PLA/TiO2)納米復(fù)合支架，探究其相關(guān)性能。 方法 在PLA中分別添加1%、1.5%、2.5%、5%和10%的TiO2納米顆粒。通過(guò)3D打印技術(shù)構(gòu)建PLA/TiO2納米復(fù)合支架，對(duì)其形貌、力學(xué)性能、孔隙率、熱性能和生物性能進(jìn)行表征。結(jié)果 與純PLA支架相比，PLA/TiO2-1.5%、PLA/TiO2-2.5%支架具有更高的孔隙率和更好的力學(xué)性能。所有支架均為層層交互疊加的網(wǎng)狀結(jié)構(gòu)，孔徑約200 μm，孔隙均勻規(guī)則。體外細(xì)胞增殖實(shí)驗(yàn)發(fā)現(xiàn)，所有支架均可促進(jìn)小鼠胚胎成骨細(xì)胞增殖，PLA/TiO2-1.5%組支架的細(xì)胞增殖效果優(yōu)于其他組支架（P<0.05）。結(jié)論 相比于其他支架，PLA/TiO2-1.5%支架具有適宜的力學(xué)性能，高孔隙率，更好地促進(jìn)細(xì)胞增殖能力，可為骨缺損修復(fù)材料研究奠定基礎(chǔ)。
Abstract:
Objective PLA/TiO2 nanocomposite scaffolds with different ratios were constructed by 3D printing technology, and their related properties were explored. Methods 1%, 1.5%, 2.5%, 5% and 10% of TiO2 nanoparticles were added to polylactic acid (PLA), respectively. The PLA/TiO2 nanocomposite scaffolds were constructed by 3D printing technology, and their morphology, mechanical properties, porosity, thermal properties and biological properties were characterized. Results Compared with pure PLA scaffolds, PLA/TiO2-1.5% and PLA/TiO2-2.5% scaffolds had higher porosity and better mechanical properties. All scaffolds were layer-by-layer reticular structures with a pore size of about 200 μm, and the pores were uniform and regular. In vitro cell proliferation experiments showed that all scaffolds could promote the proliferation of mouse embryonic osteoblasts, and the cell proliferation effect of scaffolds in PLA/TiO2-1.5% group was better than that in scaffolds in other groups (P<0.05). Conclusion Compared with other scaffolds, PLA/TiO2-1.5% scaffolds have suitable mechanical properties, high porosity, and better ability to promote cell proliferation, which can lay a foundation for the research on bone defect repair materials.

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備注/Memo

備注/Memo:
基金項(xiàng)目：福州市科技計(jì)劃項(xiàng)目(2019-SZ-23)；福建省科技創(chuàng)新平臺(tái)項(xiàng)目“福建省創(chuàng)傷骨科急救與康復(fù)臨床醫(yī)學(xué)研究中心”（2020Y2014）
更新日期/Last Update: 2023-04-15