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[1]林慧,陳佳菁,陳燕紅,等.高危型HPV檢測和TCT在宮頸癌前病變篩查中的應(yīng)用價值股骨頭中心與鄰近骨性標志關(guān)系的研究[J].福建醫(yī)藥雜志,2022,44(05):21-24.
　LIN Hui,CHEN Jiajing,CHEN Yanhong,et al.Application value of high-risk HPV detection and TCT in screening cervical precancerous lesions[J].FUJIAN MEDICAL JOURNAL,2022,44(05):21-24.
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高危型HPV檢測和TCT在宮頸癌前病變篩查中的應(yīng)用價值股骨頭中心與鄰近骨性標志關(guān)系的研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年05期
頁碼:
21-24
欄目:
臨床研究
出版日期:
2022-10-15

文章信息/Info

Title:
Application value of high-risk HPV detection and TCT in screening cervical precancerous lesions
文章編號:
1002-2600（2022）05-0021-04
作者:
林慧; 陳佳菁; 陳燕紅; 邱建龍
中國人民解放軍聯(lián)勤保障部隊第910醫(yī)院病理科（泉州 362000）
Author(s):
LIN Hui; CHEN Jiajing; CHEN Yanhong; QIU Jianlong
Department of Pathology, the 910th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Quanzhou, Fujian 362000, China
關(guān)鍵詞:
人乳頭瘤病毒; 液基細胞學; 宮頸癌前病變; 應(yīng)用價值
Keywords:
human papillomavirus;  liquid based cytology;  cervical precancerous lesions;  application value
分類號:
R737.33
文獻標志碼:
B
摘要:
目的 探討高危型人乳頭瘤病毒（HR-HPV）檢測和液基薄層細胞學檢查（TCT）在宮頸癌前病變篩查中的應(yīng)用價值。 方法 回顧性分析2018年1月至2020年12月我院的宮頸癌篩查資料。選取15 162名進行TCT和HR-HPV聯(lián)合篩查的人員作為研究對象，包括體檢11 831例，婦科患者3 331例，了解福建泉州地區(qū)不同人群HR-HPV的感染狀況。另外選取1 220例TCT、1 428例HR-HPV檢測以及843例聯(lián)合篩查數(shù)據(jù)，以宮頸活檢結(jié)果為標準，比較不同篩查方法對宮頸鱗癌前驅(qū)病變的篩查效能。 結(jié)果 HR-HPV的檢出率隨著組織學病變級別的升高而增高。以宮頸活檢結(jié)果為標準，HR-HPV檢測篩查宮頸鱗狀上皮內(nèi)病變的靈敏度為94.2%，特異度為66.2%；TCT篩查的靈敏度為79.9%，特異度為86.8%；兩種方法聯(lián)合篩查的靈敏度為97.4%，特異度為58.2%。 結(jié)論 HR-HPV檢測具有高靈敏度，更適合用于宮頸癌前病變的初篩。TCT特異性較高，適合作為HPV陽性人員的分流方法或與HR-HPV檢測聯(lián)合應(yīng)用。
Abstract:
Objective To explore the application value of high-risk human papillomavirus (HR-HPV) detection and thinprep cytology test (TCT) in the screening of cervical precancerous lesions. Methods The screening data of cervical cancer in our hospital from January 2018 to December 2020 were retrospectively analyzed.A total of 15 162 cases who underwent TCT and HR-HPV combined screening were selected as the research objects, including 11 831 physical examinations and 3 331 gynecological patients, to understand the infection status of HR-HPV in different populations in Quanzhou, Fujian province.In addition, 1 220 cases of TCT, 1 428 cases of HR-HPV detection and 843 cases of combined screening data were selected, and the screening efficacy of different screening methods for cervical squamous cell carcinoma precursor lesions were compared with the results of cervical biopsy. Results The detection rate of HR-HPV increased with the increase of histological grade.Based on the results of cervical biopsy, the sensitivity and specificity of HR-HPV detection in screening cervical squamous intraepithelial lesions were 94.2% and 66.2%, respectively. The sensitivity and specificity of TCT screening were 79.9% and 86.8%, respectively.The sensitivity and specificity of the combined screening method were 97.4% and 58.2%, respectively.Conclusion HR-HPV detection is more suitable for the primary screening of cervical precancerous lesions due to its high sensitivity.TCT has high specificity and is suitable for using as a shunt method for HPV positive persons or in combination with HR-HPV detection.

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更新日期/Last Update: 2022-10-15