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[1]陳婷玉,方鳳貞.參芪薏苡仁粥對氟尿嘧啶化療后大鼠脾氣虛癥狀和體質(zhì)量的影響[J].福建醫(yī)藥雜志,2022,44(03):115-118.
 CHEN Tingyu,FANG Fengzhen.Effects of Shen Qi Yi Yi Ren Zhou medicated porridge on spleen qi deficiency and body weight of rats after fluorouracil chemotherapy[J].FUJIAN MEDICAL JOURNAL,2022,44(03):115-118.
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參芪薏苡仁粥對氟尿嘧啶化療后大鼠脾氣虛癥狀和體質(zhì)量的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年03期
頁碼:
115-118
欄目:
基礎(chǔ)研究
出版日期:
2022-06-15

文章信息/Info

Title:
Effects of Shen Qi Yi Yi Ren Zhou medicated porridge on spleen qi deficiency and body weight of rats after fluorouracil chemotherapy
文章編號:
1002-2600(2022)03-0115-04
作者:
陳婷玉方鳳貞
福建衛(wèi)生職業(yè)技術(shù)學(xué)院(福州 350101)
Author(s):
CHEN Tingyu FANG Fengzhen
Fujian Health College, Fuzhou, Fujian 350101, China
關(guān)鍵詞:
藥膳 脾氣虛 體質(zhì)量 大鼠
Keywords:
medicated food spleen deficiency body weight rat
分類號:
R473.73
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討參芪薏苡仁粥對化療后脾氣虛大鼠脾氣虛癥狀和體質(zhì)量的影響。方法 建立化療后脾氣虛大鼠模型,24 只大鼠隨機(jī)分為空白組、藥膳組、模型組,每組8只。模型組及藥膳組給予5-氟尿嘧啶(5-Fu)制作脾氣虛大鼠模型。空白組和模型組使用0.9% 生理鹽水灌胃,藥膳組給予參芪薏苡仁粥灌胃,干預(yù) 15 d。實(shí)驗(yàn)期間觀測各組大鼠脾氣虛癥狀和體質(zhì)量變化。結(jié)果 重復(fù)測量分析結(jié)果顯示,各組間大鼠脾氣虛證候評分和體質(zhì)量變化差異具有統(tǒng)計(jì)學(xué)意義(P<0.05),且各組大鼠脾氣虛癥狀評分和體質(zhì)量隨時間變化的趨勢存在差異(P<0.05)。結(jié)論 參芪薏苡仁粥能夠明顯改善化療后大鼠脾氣虛癥狀,促進(jìn)大鼠化療后體質(zhì)量恢復(fù)。
Abstract:
Objective To observe the influence of Shen Qi Yi Yi Ren Zhou on the body weight and spleen qi deficiency syndrome in spleen qi deficiency model rats.Methods Twenty-four SPF Wistar rats were randomly assigned to three different study groups which included model group, intervention group and control group, and eight rats were included in each group.Rats in model group and intervention group were injected with 5-FU to reproduce the model of chemotherapy-induced spleen qi deficiency.During the 15 days of the study, rats in intervention group were treated with Shen Qi Yi Yi Ren Zhou 10 mL/kg,the model group and control group were treated with rice porridge at the same dose.Body weight and spleen qi deficiency syndrome were collected on the last day of experiment.Results The results of repeated measure analysis showed that there were significant differences in spleen qi deficiency syndrome score and body weight among the groups(P<0.05),and interaction between time and intervention had significant effect(P<0.05).Conclusion Shen Qi Yi Yi Ren Zhou can significantly improve the symptoms of spleen qi deficiency and promote the weight recovery of rats after chemotherapy.

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備注/Memo

備注/Memo:
基金項(xiàng)目:2018年福建省中青年教師教育科研項(xiàng)目(JZ180546); 2020年福建衛(wèi)生職業(yè)技術(shù)學(xué)院青年科研項(xiàng)目(2020-1-1)
更新日期/Last Update: 2022-06-15