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[1]鐘志輝,林焱斌,莊 研,等.骨肉瘤組織ACTN4和CD133的表達(dá)及其影響因素[J].福建醫(yī)藥雜志,2021,43(05):117-120.
 ZHONG Zhihui,LIN Yanbin,ZHUANG Yan,et al.Expression and interfering factors of ACTN4 and CD133 in osteosarcoma[J].FUJIAN MEDICAL JOURNAL,2021,43(05):117-120.
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骨肉瘤組織ACTN4和CD133的表達(dá)及其影響因素()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年05期
頁碼:
117-120
欄目:
基礎(chǔ)研究
出版日期:
2021-10-15

文章信息/Info

Title:
Expression and interfering factors of ACTN4 and CD133 in osteosarcoma
文章編號(hào):
1002-2600(2021)05-0117-04
作者:
鐘志輝林焱斌1莊 研尤龍木陳小霞吳春玲
廈門大學(xué)附屬福州第二醫(yī)院骨科(福州 350007)
Author(s):
ZHONG ZhihuiLIN YanbinZHUANG YanYOU LongmuCHEN XiaoxiaWU Chunling
Department of Orthopedics,the Affiliated Fuzhou Municipal Second Hospital,Xiamen University,Fuzhou,Fujian 350007,China
關(guān)鍵詞:
骨肉瘤 α-輔肌動(dòng)蛋白 CD133 腫瘤干細(xì)胞
Keywords:
osteosarcoma α-actinin-4 CD133 cancer stem cells
分類號(hào):
R738.1
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 觀察α-輔肌動(dòng)蛋白(α-actinin-4,ACTN4)和CD133在骨肉瘤組織中的表達(dá)情況,并探討影響兩者表達(dá)的相關(guān)因素。方法 收集2015年1月至2018 年1月經(jīng)病理確診為骨肉瘤的50例患者臨床病理資料,應(yīng)用免疫組化檢測(cè)ACTN4和CD133的蛋白表達(dá)情況,分析各因素不同水平間ACTN4和CD133蛋白表達(dá)的差異。結(jié)果 ACTN4在骨肉瘤組織中陽性率為58%,CD133在骨肉瘤組織中陽性率為54%,兩者陽性率均高于其在骨軟骨瘤組織中的表達(dá),差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05)。不同Enneking外科分期、肺轉(zhuǎn)移之間的ACTN4表達(dá)差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。不同Enneking外科分期、局部復(fù)發(fā)和肺轉(zhuǎn)移之間的CD133表達(dá)差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 ACTN4和CD133在骨肉瘤發(fā)生、發(fā)展中具有重要作用。
Abstract:
Objective To observe the expression of α-actinin-4(ACTN4)and CD133 in osteosarcoma and to explore the related factors affecting their expression.Methods The clinicopathological data of 50 patients with osteosarcoma diagnosed by pathology from January 2015 to January 2018 were collected.The protein expression of ACTN4 and CD133 was detected by immunohistochemistry,and the differences of protein expression among different levels of various factors were further analyzed.Results The positive rates of ACTN4 and CD133 in osteosarcoma were 58% and 54%, respectively.Both positive rates were higher than their expression in osteochondroma.There were significant differences in the expression of ACTN4 between different Enneking surgical stages and lung metastasis(P<0.05).There were significant differences in the expression of CD133 between different Enneking surgical stages,local recurrence and lung metastasis(P<0.05).Conclusion ACTN4 and CD133 play an important role in the occurrence and development of osteosarcoma.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金面上項(xiàng)目(2020J011189)
1 通信作者,Email:[email protected]
更新日期/Last Update: 2021-10-15