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[1]周雨燕,林,帆,等.Apelin-13對(duì)高糖誘導(dǎo)的功能障礙血管內(nèi)皮的作用探討[J].福建醫(yī)藥雜志,2021,43(04):136-137.
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Apelin-13對(duì)高糖誘導(dǎo)的功能障礙血管內(nèi)皮的作用探討()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年04期
頁(yè)碼:
136-137
欄目:
基礎(chǔ)研究
出版日期:
2021-08-15

文章信息/Info

文章編號(hào):
1002-2600(2021)04-0136-03
作者:
周雨燕葉志強(qiáng)朱鵬立1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院老年科(福州 350101)
關(guān)鍵詞:
Apelin-13高糖凋亡增殖人臍靜脈內(nèi)皮細(xì)胞
分類號(hào):
R587.1
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討Apelin-13對(duì)高糖環(huán)境下人臍靜脈內(nèi)皮細(xì)胞(HUVECs)是否具有保護(hù)作用。 方法 實(shí)驗(yàn)Ⅰ,CCK-8法檢測(cè)48 h后HUVECs在不同糖濃度環(huán)境下的增殖活性。實(shí)驗(yàn)Ⅱ,實(shí)驗(yàn)分組為空白對(duì)照組、模型組、實(shí)驗(yàn)組,分別培養(yǎng)16、24、48 h,CCK-8檢測(cè)細(xì)胞增殖活性。實(shí)驗(yàn)Ⅲ,實(shí)驗(yàn)分組為空白對(duì)照組、模型組、實(shí)驗(yàn)組,48 h后流式細(xì)胞術(shù)檢測(cè)細(xì)胞凋亡率。 結(jié)果 選擇33 mmol/L作為高糖損傷模型的糖濃度。Apelin可改善高糖環(huán)境下的HUVECs增殖活性,且48 h作用時(shí)間、10-8 mol/L Apelin的條件下,Apelin的增益效果更明顯。Apelin可抑制高糖環(huán)境下的HUVECs的早期凋亡。 結(jié)論 Apelin/APJ軸對(duì)高糖誘導(dǎo)的血管內(nèi)皮功能障礙起保護(hù)作用。

參考文獻(xiàn)/References:

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更新日期/Last Update: 2021-08-15