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[1]程輝.基于數(shù)據(jù)挖掘分析G蛋白偶聯(lián)受體116在彌漫大B細(xì)胞淋巴瘤中的表達(dá)及功能預(yù)測[J].福建醫(yī)藥雜志,2021,43(03):22-26.
　CHENG Hui.Analysis of GPR116 expression and function prediction in diffuse large B cell lymphoma based on data mining[J].FUJIAN MEDICAL JOURNAL,2021,43(03):22-26.
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基于數(shù)據(jù)挖掘分析G蛋白偶聯(lián)受體116在彌漫大B細(xì)胞淋巴瘤中的表達(dá)及功能預(yù)測()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期數(shù):
2021年03期
頁碼:
22-26
欄目:
臨床研究
出版日期:
2021-06-15

文章信息/Info

Title:
Analysis of GPR116 expression and function prediction in diffuse large B cell lymphoma based on data mining
文章編號:
1002-2600(2021)03-0022-05
作者:
程輝
福建省立醫(yī)院病理科(福州 350001)
Author(s):
CHENG Hui
Department of Pathology, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
GPR116;  彌漫大B細(xì)胞淋巴瘤;  生物信息學(xué);  預(yù)后
Keywords:
GPR116;  diffuse large B-cell lymphoma;  bioinformatics;  prognosis
分類號:
R733.4
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 通過數(shù)據(jù)挖掘分析G蛋白偶聯(lián)受體116(GPR116)在彌漫大B細(xì)胞淋巴瘤(DLBCL)中的表達(dá)及功能預(yù)測。方法 基于多個國際公認(rèn)數(shù)據(jù)庫中有關(guān) GPR116的表達(dá)譜及臨床數(shù)據(jù),分析DLBCL中GPR116的表達(dá)情況、臨床病理參數(shù)及生存預(yù)后的關(guān)系,并通過基因本體(GO)分析以及京都基因與基因組百科全書(KEGG)分析對GPR116進(jìn)行功能注釋及通路富集分析。結(jié)果 與正常對照相比,GPR116在DLBCL中的表達(dá)顯著上調(diào),其表達(dá)與DLBCL患者的年齡、性別、腫瘤分期等相關(guān),與DLBCL患者預(yù)后不良有關(guān)。GPR116共表達(dá)基因主要參與細(xì)胞外結(jié)構(gòu)、細(xì)胞外基質(zhì)組成、血管形成調(diào)節(jié)及細(xì)胞基質(zhì)黏附等過程,并顯著富集于多個致癌信號通路、黏著斑途徑、ECM-受體相互作用等相關(guān)通路。結(jié)論 GPR116在DLBCL中起癌基因的作用,可能是DLBCL的一個可靠的診療靶點。
Abstract:
Objective To analyze GPR116 expression and function prediction in diffuse large B cell lymphoma by data mining.Methods Based on the expression profiles and clinical data of GPR116 in several internationally recognized databases, we analyzed the expression of GPR116 and the relationship between clinicopathological parameters and survival prognosis.And we further predicted the possible biological function by GO and KEGG analysis.Results Compared with the control, GPR116 expression in DLBCL was significantly up-regulated, which was related to the age, gender, tumor stage of DLBCL, and the patients with high GPR116 expressions had poor prognosis.GPR116 co-expressed genes were mainly involved in the process of extracellular structure, extracellular matrix composition, vascular regulation and matrix adhesion, and were significantly enriched in multiple carcinogenic signaling pathways, focal adhesion, ECM-receptor interaction.Conclusion GPR116 plays a role of oncogene in DLBCL, which may be a reliable diagnosis and treatment target of DLBCL.

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更新日期/Last Update: 2021-06-15