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[1]吳永希 林懿祺 莊文錦 吳欽偉 李 振 曾昭楠 謝曉亮 魏世超.發(fā)作性睡病與阻塞性睡眠呼吸暫停相關(guān)分析[J].福建醫(yī)藥雜志,2020,42(05):11-15.
　WU Yongxi,LIN Yiqi,ZHUANG Wenjin,et al.Correlation analysis between narcolepsy and obstructive sleep apnea[J].FUJIAN MEDICAL JOURNAL,2020,42(05):11-15.
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發(fā)作性睡病與阻塞性睡眠呼吸暫停相關(guān)分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年05期
頁碼:
11-15
欄目:
臨床研究
出版日期:
2020-10-20

文章信息/Info

Title:
Correlation analysis between narcolepsy and obstructive sleep apnea
文章編號:
1002-2600(2020)05-0011-06
作者:
吳永希 林懿祺 莊文錦 吳欽偉 李 振 曾昭楠 謝曉亮 魏世超1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院睡眠醫(yī)學(xué)中心(福州 350001)
Author(s):
WU Yongxi;  LIN Yiqi;  ZHUANG Wenjin;  WU Qinwei;  LI Zhen;  ZENG Zhaonan; XIE Xiaoliang;  WEI Shichao
Department of Sleep Medicine Center, Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou,Fujian 350001, China
關(guān)鍵詞:
發(fā)作性睡病;  阻塞性睡眠呼吸暫停;  多導(dǎo)睡眠監(jiān)測
Keywords:
narcolepsy;  obstructive sleep apnea;  PSG
分類號:
R766
文獻標志碼:
B
摘要:
目的 探討發(fā)作性睡病伴與不伴阻塞性睡眠呼吸暫停(obstructive sleep apnea,OSA)患者的睡眠特點及相關(guān)危險因素。方法 納入發(fā)作性睡病患者25例,對其進行多導(dǎo)睡眠監(jiān)測(PSG)、日間多次小睡潛伏期試驗(MSLT)以及愛潑沃斯嗜睡量表(ESS)評估,觀察并分析發(fā)作性睡病伴OSA組(n=12)與不伴OSA組(n=13)的睡眠特點及危險因素。結(jié)果 發(fā)作性睡病伴OSA組ESS得分為(18.08±4.14)分,高于發(fā)作性睡病不伴OSA組的(12.69±6.66)分,差異有統(tǒng)計學(xué)意義(t=2.449,P=0.024); 發(fā)作性睡病伴OSA組N1期百分比為(28.65±12.50)%,高于發(fā)作性睡病不伴OSA組的(16.50±10.22)%,差異有統(tǒng)計學(xué)意義(t=2.670,P=0.014); 發(fā)作性睡病伴OSA組N3期百分比為(10.64±4.96)%,低于發(fā)作性睡病不伴OSA組的(17.75±8.83)%,差異有統(tǒng)計學(xué)意義(t=2.504,P=0.021); 發(fā)作性睡病伴OSA組睡眠期覺醒總次數(shù)為(196.17±83.69)次,多于發(fā)作性睡病不伴OSA組的(112.30±73.12)次,差異有統(tǒng)計學(xué)意義(t=2.674,P=0.014); 發(fā)作性睡病伴OSA組睡眠期覺醒指數(shù)為19.95(17.15,29.13))次/h,高于發(fā)作性睡病不伴OSA組的13.20(7.85,19.15))次/h,差異有統(tǒng)計學(xué)意義(Z=2.720,P=0.007)。多因素logistic回歸分析發(fā)現(xiàn),覺醒指數(shù)為發(fā)作性睡病伴OSA的危險因素,相對危險度(OR值)為1.179[95%CI(1.017～1.367),P=0.029]。結(jié)論 發(fā)作性睡病伴OSA的發(fā)生率較高,且夜間睡眠紊亂、日間嗜睡程度更嚴重,臨床上應(yīng)注意鑒別。
Abstract:
Objective To investigate the sleep characteristics and related risk factors of patients with obstructive sleep apnea(OSA)or without sleep disorder based on narcolepsy.Methods A total of 25 patients with narcolepsy were enrolled.PSG monitoring, multiple sleep latency test(MSLT)and Epworth sleepiness scale(ESS)were used to evaluate the sleep characteristics and risk factors of narcolepsy with OSA group(n=12)and without OSA group(n=13).Results ESS score was higher in narcolepsy patients with OSA than that in those without OSA narcolepsy,with OSA group(18.08±4.14)points vs the narcolepsy without OSA group(12.69 ±6.66)points(t=2.449, P=0.024).OSA increased N1 percentage [(28.65±12.50)% vs(16.50±10.22)%, t=2.670, P=0.014)], decreased N3 percentage [(10.64±4.96)% vs(17.75±8.83)%, t=2.504,P=0.021)], increased total number of awakening during sleep period [(196.17±83.69)vs(112.30±73.12); t=2.674, P=0.014], and increased awakening index [19.95(17.15, 29.13)times/hour vs 13.20(7.85, 19.15)times/hour; Z=2.720, P=0.007].Multivariate logistic regression analysis showed that the arousal index was a risk factor for episodic sleep disease with OSA, and the odd ratio(OR)was 1.179[95%CI(1.017-1.367),P=0.029].Conclusion The incidence of narcolepsy with OSA is high.Compared to narcolepsy patients without OSA, nocturnal sleep disorder and daytime sleepiness are more serious in narcolepsy patients with OSA, which should be clinically differentiated.

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備注/Memo

備注/Memo:
基金項目:福建醫(yī)科大學(xué)啟航基金(2019QH1174) 1 通信作者,Email:[email protected]
更新日期/Last Update: 2020-10-20