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[1]林智平 王 英 王蘭蘭 羅益平.老年宮頸癌患者外周血S100A8水平和術(shù)后認(rèn)知功能障礙發(fā)生的關(guān)系[J].福建醫(yī)藥雜志,2020,42(05):5-7.
　LIN Zhiping,WANG Ying,WANG Lanlan,et al.Relationship between peripheral blood S100A8 level and postoperative cognitive dysfunction in elderly patients with cervical cancer[J].FUJIAN MEDICAL JOURNAL,2020,42(05):5-7.
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老年宮頸癌患者外周血S100A8水平和術(shù)后認(rèn)知功能障礙發(fā)生的關(guān)系()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年05期
頁(yè)碼:
5-7
欄目:
臨床研究
出版日期:
2020-10-20

文章信息/Info

Title:
Relationship between peripheral blood S100A8 level and postoperative cognitive dysfunction in elderly patients with cervical cancer
文章編號(hào):
1002-2600(2020)05-0005-03
作者:
林智平 王 英 王蘭蘭 羅益平
福建省腫瘤醫(yī)院 福建醫(yī)科大學(xué)附屬腫瘤醫(yī)院麻醉科(福州 350014)
Author(s):
LIN Zhiping;  WANG Ying; WANG Lanlan; LUO Yiping
Department of Anesthesiology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital,Fuzhou,Fujian 350014,China
關(guān)鍵詞:
老年患者;  術(shù)后認(rèn)知功能障礙;  S100A8;  宮頸癌
Keywords:
elderly patients;  postoperative cognitive dysfunction;  S100A8;  cervical cancer
分類(lèi)號(hào):
R737.33
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 觀察老年宮頸癌患者行全身麻醉術(shù)后認(rèn)知功能障礙(postoperative cognitive dysfunction,POCD)的發(fā)生情況,并探討外周血S100A8表達(dá)變化與其發(fā)生的關(guān)系。方法 選取全身麻醉下行擇期開(kāi)放性宮頸癌根治術(shù)的老年患者50例,年齡60～80歲。于術(shù)前1 d和術(shù)后7 d對(duì)患者及其一位健康家屬進(jìn)行兩次認(rèn)知功能測(cè)試,采用Z計(jì)分法判斷患者術(shù)后7 d是否出現(xiàn)POCD。于術(shù)前1 d和術(shù)后7 d采集患者外周血,采用qRT-PCR方法檢測(cè)外周血單個(gè)核細(xì)胞(peripheral blood mononuclear Cells, PBMCs)中S100A8的表達(dá)水平。根據(jù)患者是否出現(xiàn)POCD,將患者分為POCD組和非POCD組,采用t檢驗(yàn)分析兩組患者術(shù)前術(shù)后S100A8表達(dá)改變和POCD發(fā)生的關(guān)系。結(jié)果 50例老年患者中有12例出現(xiàn)POCD,發(fā)生率為24%。兩組患者外周血的 S100A8表達(dá)水平在術(shù)前差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05); 術(shù)后7 d,POCD組的S100A8表達(dá)水平較術(shù)前以及較非POCD組差異有統(tǒng)計(jì)學(xué)意義(P<0.05),非POCD組的S100A8表達(dá)水平較術(shù)前差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論 老年宮頸癌患者早期POCD發(fā)生率較高,需引起足夠重視。術(shù)后7 d外周血S100A8水平與患者早期POCD的發(fā)生密切相關(guān),并對(duì)其是否出現(xiàn)早期POCD可能有一定診斷價(jià)值。
Abstract:
Objective To observe the incidence of postoperative cognitive dysfunction(POCD)in elderly patients with cervical cancer after general anesthesia, and to explore the relationship between S100A8 expression in peripheral blood and the occurrence of POCD.Methods Fifty elderly patients, aged 60-80 years, undergoing elective open radical operation for cervical cancer under general anesthesia were selected.The cognitive function of patients and a healthy family member of them were tested one day before operation and seven days after operation, and Z score method was used to judge whether POCD appeared in the patients seven days after operation.Patients peripheral bloods were collected one day before and seven days after operation, and the expression levels of S100A8 in peripheral blood mononuclear cells(PBMCs)were detected by qRT-PCR.According to whether patients had POCD, they were divided into POCD group and non-POCD group.T test was used to analyze the relationship between the changes of S100A8 expression before and after operation and the occurrence of POCD.Results Twelve of 50 elderly patients had POCD, and the incidence rate was 24%.The expression levels of S100A8 in peripheral blood of two groups had no significant difference before operation(P>0.05).Seven days after operation, the expression level of S100A8 in POCD group was significantly higher than that before operation and that in non-POCD group(P<0.05), while the expression level of S100A8 in non-POCD group had no obvious change compared with that before operation(P>0.05).Conclusion The incidence of early POCD in elderly patients with cervical cancer is high, which should be paid enough attention to.The level of S100A8 in peripheral blood seven days after operation is closely related to the occurrence of early POCD in elderly patients with cervical cancer, and may have some diagnostic value for the occurrence of early POCD.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金資助項(xiàng)目(2018J01272)
更新日期/Last Update: 2020-10-20