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[1]查小云 魏長順 賴鵬斌.胰腺纖維鈣化性糖尿病16例臨床特點分析并文獻復(fù)習(xí)[J].福建醫(yī)藥雜志,2020,42(04):14-17.
　ZHA Xiaoyun,WEI Changshun,LAI Pengbin..Analysis of clinical characteristics of 16 cases with fibrocalculous pancreatic diabetes and literature review[J].FUJIAN MEDICAL JOURNAL,2020,42(04):14-17.
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胰腺纖維鈣化性糖尿病16例臨床特點分析并文獻復(fù)習(xí)()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年04期
頁碼:
14-17
欄目:
臨床研究
出版日期:
2020-08-20

文章信息/Info

Title:
Analysis of clinical characteristics of 16 cases with fibrocalculous pancreatic diabetes and literature review
文章編號:
1002-2600(2020)04-0014-04
作者:
查小云 魏長順 賴鵬斌1
福建醫(yī)科大學(xué)附屬漳州市醫(yī)院內(nèi)分泌代謝一科(漳州 363000)
Author(s):
ZHA Xiaoyun; WEI Changshun;  LAI Pengbin.
The First Department of Endocrinology and Metabolism,the Affiliated Zhangzhou Municipal Hospital,Fujian Medical University, Zhangzhou, Fujian 363000, China
關(guān)鍵詞:
糖尿病;  胰腺纖維鈣化;  胰管結(jié)石
Keywords:
diabetes;  fibrocalculous pancreatic;  pancreatic calculus
分類號:
R587.1
文獻標志碼:
B
摘要:
目的 分析胰腺纖維鈣化性糖尿病(fibrocalculous pancreatic diabetes,FCPD)的臨床特點,提高臨床對FCPD的認識。方法 采用回顧性分析,對2015至2019年間我院收治的16例FCPD患者從性別比例、發(fā)病年齡、臨床特征、實驗室檢查、影像學(xué)特征及治療方法進行綜合分析,并對其中1例典型患者進行詳細病例報告。結(jié)果 我院診斷的16例FCPD患者中男8例,女8例,確診年齡23～67歲,平均確診年齡女性38歲,男性51歲,男性的平均確診年齡高于女性,差異有統(tǒng)計學(xué)意義。8例患者有腹痛癥狀。3例患者有飲酒史,所有患者均無長期木薯進食史。分別通過CT、MRI或手術(shù)病理(1例)證實存在胰管結(jié)石和/或胰腺萎縮。絕大部分患者(12例)均體形中等不瘦、胰腺萎縮; 所有患者C肽均有不同程度降低; 僅有4例患者出現(xiàn)酮癥,其中1例為酮癥酸中毒; 11例患者接受胰島素治療,5例患者應(yīng)用口服降糖藥物可維持血糖穩(wěn)定。結(jié)論 1)FCPD的經(jīng)典三聯(lián)征是腹痛、胰腺炎和糖尿病,但癥狀常常不典型而漏診。2)對于胰島功能差但無酮癥傾向、無糖尿病家族史的糖尿病患者應(yīng)注意篩查FCPD,CT或MR可助診,確診后盡早手術(shù)治療有利于胰島細胞功能修復(fù)。
Abstract:
Objective To analyze the clinical characteristics of fibrocalculous pancreatic diabetes(FCPD), and to improve clinical understanding of FCPD.Methods Retrospective analysis was used to comprehensively analyze the 16 FCPD cases admitted in our hospital from 2015 to 2019, age of onset, clinical characteristics, laboratory examinations, imaging characteristics and treatment methods were discussed, and one of the typical cases was reported in detail.Results Among the sixteen cases, there were eight male and eight female.The diagnose age was 23-67 years old.The average diagnose age in men(51 years old)was significantly higher than that in women(38 years old).A total of eight cases had symptoms of abdominal pain,three cases had a history of alcohol consumption, and none cases had long-term cassava eating history.The pancreatic calculus and(or)pancreatic atrophy were confirmed by CT, MRI, or surgical pathology(one case).The majority patients(12 cases)were with moderately lean and pancreatic atrophy, and all patients had C-peptide decreased.Only four patients developed ketosis, including one with diabetic ketoacidosis.A total of eleven cases were treated with insulin and five cases were treated with oral antidiabetic drug to control blood sugar.Conclusion 1)The classic clinical symptoms of FCPD is abdominal pain, pancreatitis and diabetes, but often atypical and misdiagnosed.2)For diabetic patients with poor pancreas islet function but no ketosis and no family history of diabetes,attention should be paid to screening FCPD.CT or MR scan are useful for final diagnosis of FCPD and early surgical treatment is helpful for insulin cell function repair.

參考文獻/References:

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更新日期/Last Update: 2020-08-20