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[1]黎 冉.阿托伐他汀鈣干預(yù)對冠心病患者圍術(shù)期心臟事件的影響[J].福建醫(yī)藥雜志,2020,42(01):26-28.
　LI Ran..Effect of atorvastatin calcium on perioperative cardiac events in patients with coronary heart disease[J].FUJIAN MEDICAL JOURNAL,2020,42(01):26-28.
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阿托伐他汀鈣干預(yù)對冠心病患者圍術(shù)期心臟事件的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期數(shù):
2020年01期
頁碼:
26-28
欄目:
臨床研究
出版日期:
2020-03-30

文章信息/Info

Title:
Effect of atorvastatin calcium on perioperative cardiac events in patients with coronary heart disease
文章編號:
1002-2600(2020)01-0026-03
作者:
黎 冉
福建醫(yī)科大學(xué)第二臨床醫(yī)學(xué)院 福建醫(yī)科大學(xué)附屬第二醫(yī)院(泉州 362000)
Author(s):
LI Ran.
The Second Affiliated Hospital of Fujian Medical University, The Second Clinical Medical College of Fujian Medical University,Quanzhou,Fujian 362000, China
關(guān)鍵詞:
冠心病;  心臟事件;  高敏C反應(yīng)蛋白;  阿托伐他汀鈣
Keywords:
coronary heart disease;  heart event;  high sensitive C-reactive protein;  atorvastatin calcium
分類號:
R541.4
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討阿托伐他汀鈣術(shù)前干預(yù)對冠心病患者圍術(shù)期發(fā)生心臟事件的影響。方法 收集本院住院確診為冠心病的非心臟手術(shù)患者120例(已服用阿托伐他汀鈣20 mg/d)。根據(jù)臨床特點(diǎn)隨機(jī)分為經(jīng)過增加阿托伐他汀鈣調(diào)控的觀察組40 mg/d和阿托伐他汀鈣20 mg/d調(diào)控的對照組。比較兩組高敏C反應(yīng)蛋白水平、肌酸激酶水平及患者圍術(shù)期心臟事件發(fā)生的情況。結(jié)果 觀察組高敏C反應(yīng)蛋白平均水平為(4.88±2.19)mg/L,對照組為(7.95±2.21)mg/L,兩組比較的差異有統(tǒng)計(jì)學(xué)意義(P<0.05); 干預(yù)后觀察組肌酸激酶水平為(15.99±146.7)U/L,對照組為(127.4±66.0)U/L; 術(shù)后并發(fā)癥發(fā)生比較的差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 術(shù)前40 mg劑量阿托伐他汀鈣干預(yù)可減少冠心病患者圍術(shù)期心臟事件的發(fā)生。
Abstract:
Objective To explore the effect of preoperative intervention of atorvastatin calcium on perioperative cardiac events in patients with coronary heart disease.Methods A total of 120 patients(20 mg/d of atorvastatin calcium)with coronary heart disease were collected.According to the clinical characteristics, the patients were randomly divided into two groups: observation group(40 mg/d)and control group(20 mg/d).The level of high-sensitivity C-reactive protein, the level of creatine kinase and the occurrence of perioperative cardiac events were compared between the two groups.Results The average level of high sensitive C-reactive protein was(4.88±2.19)mg/L in the observation group and(7.95±2.21)mg/L in the control group, the difference between the two groups was statistically significant(P<0.05),Creatine kinase level in the observation group was(159.9±146.7)U/L,while it was(127.4±66.0)U/L in control group. and the difference between the postoperative complications was statistically significant(P<0.05).Conclusion The intervention of 40 mg of atorvastatin calcium before operation can reduce the occurrence of perioperative cardiac events in patients with coronary heart disease.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省中青年教師教育科研項(xiàng)目(JAT170247); 福建醫(yī)科大學(xué)校苗圃科研基金項(xiàng)目(2015MP033)
更新日期/Last Update: 2020-03-30