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[1]郭慈仁 林 潔 石懷景 陳桂林 江信燕.嗜神經(jīng)侵襲與宮頸癌根治術(shù)后遠處轉(zhuǎn)移的關(guān)系[J].福建醫(yī)藥雜志,2019,41(06):16-18.
　GUO Ciren,LIN Jie,SHI Huaijing,et al.Relationship between perineural invasion and distant metastasis of cervical cancer after radical operation[J].FUJIAN MEDICAL JOURNAL,2019,41(06):16-18.
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嗜神經(jīng)侵襲與宮頸癌根治術(shù)后遠處轉(zhuǎn)移的關(guān)系()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期數(shù):
2019年06期
頁碼:
16-18
欄目:
臨床研究
出版日期:
2019-12-25

文章信息/Info

Title:
Relationship between perineural invasion and distant metastasis of cervical cancer after radical operation
文章編號:
1002-2600(2019)06-0016-04
作者:
郭慈仁 林 潔1 石懷景 陳桂林 江信燕
福建醫(yī)科大學(xué)附屬腫瘤醫(yī)院 福建省腫瘤醫(yī)院婦科(福州 350014)
Author(s):
GUO Ciren;  LIN Jie; SHI Huaijing; CHEN Guilin;  JIANG Xinyan.
Department of Tumor Gynecology, Fujian Medical University Cancer Hospital & Fujian Cancer Hospital, Fuzhou,Fujian 350014, China
關(guān)鍵詞:
宮頸腫瘤;  嗜神經(jīng)侵襲;  遠處轉(zhuǎn)移
Keywords:
cervical neoplasm;  perineural invasion;  distant metastasis
分類號:
R737.33
文獻標志碼:
B
摘要:
目的 探討嗜神經(jīng)侵襲(perineural invasion,PNI)在宮頸癌中的發(fā)生情況及其與術(shù)后遠處轉(zhuǎn)移的關(guān)系。方法 回顧性分析2014年2月至2017年8月在我院行廣泛性全子宮切除加盆腔淋巴結(jié)清掃術(shù)的Ⅰb～Ⅱb期157例宮頸癌患者的臨床資料,觀察PNI的發(fā)生情況,并分析PNI與各臨床病理因素及術(shù)后遠處轉(zhuǎn)移的關(guān)系。結(jié)果 1)157例宮頸癌患者中有19例發(fā)生PNI,陽性率為12.1%; 2)宮頸癌PNI的發(fā)生與淋巴結(jié)轉(zhuǎn)移、脈管癌栓、宮旁浸潤及深肌層浸潤明顯相關(guān)(均P<0.05),而與年齡、腫瘤直徑、臨床分期、組織學(xué)類型、組織學(xué)分級及陰道切緣無關(guān)(均P>0.05); 3)PNI陽性患者的術(shù)后遠處轉(zhuǎn)移率(15.8%)明顯高于PNI陰性者(3.6%),兩者間差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 宮頸癌存在PNI現(xiàn)象,其發(fā)生與術(shù)后遠處轉(zhuǎn)移密切相關(guān),有望成為判斷宮頸癌預(yù)后的一個新指標。
Abstract:
Objective To investigate the occurrence of perineural invasion(PNI)in cervical cancer and its relationship with distant metastasis after radical operation.Methods A total of 157 cases of patients with cervical cancer(stage Ⅰb-Ⅱb)who underwent radical hysterectomy and pelvic lymphadenectomy from Feb 2014 to Aug 2017 were retrospectively analyzed.The occurrence of PNI was observed and its relationships with clinicopathological characteristics and distant metastasis after radical operation were analyzed.Results The positive rate of PNI was 12.1%(19/157).PNI had a significant association with lymph nodes metastases, lymphoma vascular space invasion, parametrical invasion and depth of invasion(P<0.05), but had nothing to do with patient age, tumor size, FIGO stage, pathological type, histological grade and vaginal margin(P>0.05).Postoperative distant metastasis rate of PNI positive patients(15.8%)was significantly higher than that of PNI negative patients(3.6%),and there was a significant difference between the two groups.Conclusion PNI exists in cervical cancer, and its occurrence is closely related to distant metastasis after operation.It is expected to become a new index to judge the prognosis of cervical cancer after operation.

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備注/Memo

備注/Memo:
基金項目:福建省自然科學(xué)基金項目(2016J01505)
更新日期/Last Update: 2019-12-25