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[1]衣 歡 鄭祥欽 宋建榕 蘇彥釗 吳花敏 林 蓉 徐鷺鷺 黃湧彬.卵巢癌外泌體攜運miRNAs調(diào)控葡萄糖代謝生物信息學分析[J].福建醫(yī)藥雜志,2019,41(05):117-119.
 YI Huan,ZHENG Xiangqin,SONG Jianrong,et al.Bioinformatics analysis of ovarian-cancer-secreted exosomal miRNAs regulating glucose metabolism[J].FUJIAN MEDICAL JOURNAL,2019,41(05):117-119.
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卵巢癌外泌體攜運miRNAs調(diào)控葡萄糖代謝生物信息學分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期數(shù):
2019年05期
頁碼:
117-119
欄目:
基礎(chǔ)研究
出版日期:
2019-10-15

文章信息/Info

Title:
Bioinformatics analysis of ovarian-cancer-secreted exosomal miRNAs regulating glucose metabolism
文章編號:
1002-2600(2019)05-0117-03
作者:
衣 歡 鄭祥欽 宋建榕1 蘇彥釗 吳花敏 林 蓉 徐鷺鷺2 黃湧彬2
福建醫(yī)科大學附屬醫(yī)院 福建省婦幼保健院(福州 350001)
Author(s):
YI Huan ZHENG Xiangqin SONG Jianrong SU YanzhaoWU Huamin LIN Rong XU Lulu HUANG Yongbin
Fujian Provincial Maternity and Childrens Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou,Fujian 350001, China
關(guān)鍵詞:
卵巢癌 生物信息學 外泌體 微小RNA 葡萄糖代謝 分子標記物
Keywords:
ovarian cancer bioinformatics exosome miRNA glucose metabolism biomarkers
分類號:
R711.75
文獻標志碼:
A
摘要:
目的 研究卵巢癌外泌體的差異表達微小RNA(miRNA)和富集通路,篩選診治、預(yù)后判斷分子標志物。 方法 從高通量基因表達數(shù)據(jù)庫(GEO)下載并分析獲得在卵巢癌外泌體明顯富集差異表達的miRNA基因數(shù)據(jù)集(GSE)76449。應(yīng)用生物信息學和蛋白質(zhì)譜分析方法,篩選外泌體攜運miRNA的靶向通路和預(yù)后靶標。結(jié)果 共篩選出32個外泌體富集差異表達miRNAs,基因本體(GO)和代謝途徑分析數(shù)據(jù)庫(KEGG)分析顯示,差異miRNAs基因主要富集在細胞氮化合物代謝功能以及鞘糖脂生物合成——乳酸和內(nèi)酯系列和粘蛋白型O-聚糖生物合成等信號通路,預(yù)后分析發(fā)現(xiàn)miRNA-337-3p高表達、miRNA-6809-3p預(yù)測靶基因WNT3低表達和共表達蛋白卷曲蛋白4基因(FZD4)、干細胞生長因子(HGF)都與卵巢癌不良預(yù)后密切有關(guān)。結(jié)論 外泌體富集葡萄糖代謝相關(guān)miRNAs可能與卵巢癌發(fā)生發(fā)展有關(guān),可為卵巢癌的診療提供新思路。
Abstract:
Objective To study differentially expressed miRNAs and enrichment pathways in exosomes derived from ovarian cancer and screen molecular markers for diagnosis, treatment and prognosis.Methods One set of exosomal miRNA expression profile data related to ovarian cancer(GSE76449)were downloaded from GEO database, then up-regulated miRNAs were obtained by differentially expressed analysis.The combination usage of bioinformatics and mass spectrometry were analyzed for functional annotation pathway and prognostic biamarkers.Results A total of 32 differentially expressed miRNAs were obtained.Based on the GO and KEGG function annotation, miRNA were mainly enriched in the function of cellular nitrogen compound metabolic process and the pathway of glycosphingolipid and mucin type O-glycan biosynthesis.By analyzing prognosis of network node, miR-337-3p were found to be upregulated.MiR-6809-3p predicted target gene WNT3 and coexpressed proteins including FZD4、HGF were all associated with the poor outcome of patients with ovarian cancer.Conclusion Exosomal miRNAs influenced glucose metabolism is related to the progress of ovarian cancer and provided new strategies for the diagnosis and treatment of ovarian cancer.

參考文獻/References:

[1] Itamochi H, Kigawa J.Molecular targeted therapies for epithe-lial ovarian cancer[J]. Nihon Rinsho,2012, 70(S4): 622-627.
[2] Kroeger P J, Drapkin R.Pathogenesis and heterogeneity of ovarian cancer[J]. Curr Opin Obstet Gynecol,2017, 29(1): 26-34.
[3] Squadrito M L, Baer C, Burdet F, et al.Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells[J]. Cell Rep,2014, 8(5): 1432-1446.
[4] Taylor D D, Gercel-Taylor C.MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer[J]. Gynecol Oncol,2008, 110(1): 13-21.
[5] Deng J L, Xu Y H, Wang G.Identification of Potential Crucial Genes and Key Pathways in Breast Cancer Using Bioinformatic Analysis[J]. Front Genet,2019, 10: 695.
[6] Reczko M, Maragkakis M, Alexiou P, et al.Functional microRNA targets in protein coding sequences[J]. Bioinfor-matics,2012, 28(6): 771-776.
[7] Yi H, Ye J, Yang X M, et al.High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis[J]. Int J Clin Exp Pathol,2015, 8(5): 5062-5070.
[8] Yi H, Zheng X, Song J, et al.Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis[J]. Int J Clin Exp Pathol,2015, 8(12): 15719-15728.
[9] Zeng Z, Li Y, Pan Y, et al.Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis[J]. Nat Commun,2018, 9(1): 5395.
[10] Fong M Y, Zhou W, Liu L, et al.Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis[J]. Nat Cell Biol,2015, 17(2): 183-194.
[11] Ippolito L, Marini A, Cavallini L, et al.Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells[J]. Oncotarget,2016, 7(38): 61890-61904.
[12] Wang Z, Wang J, Yang Y, et al.Loss of has-miR-337-3p expression is associated with lymph node metastasis of human gastric cancer[J]. J Exp Clin Cancer Res,2013, 32: 76.
[13] Guo X, Han T, Hu P, et al.Five microRNAs in serum as potential biomarkers for prostate cancer risk assessment and therapeutic intervention[J]. Int Urol Nephrol,2018, 50(12): 2193-2200.

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備注/Memo

備注/Memo:
基金項目:福建省自然科學基金資助項目(2016J01430); 福建省衛(wèi)生計生青年科研課題(2016-1-16) 1 通信作者; 2 福建醫(yī)科大學
更新日期/Last Update: 2019-10-15