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[1]熊紅萍 徐 靜 周 強 吳埼淇 甘國翔 陳忠山.鹽酸小檗堿對糖尿病患者血糖、胃腸激素及腸道菌群的影響[J].福建醫(yī)藥雜志,2019,41(01):6-9.
　XIONG Hongping,XV Jing,ZHOU Qiang,et al.Effect of berberine on blood glucose,gastrointestinal hormones and intestinal flora of diabetic patients[J].FUJIAN MEDICAL JOURNAL,2019,41(01):6-9.
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鹽酸小檗堿對糖尿病患者血糖、胃腸激素及腸道菌群的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期數(shù):
2019年01期
頁碼:
6-9
欄目:
臨床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Effect of berberine on blood glucose,gastrointestinal hormones and intestinal flora of diabetic patients
文章編號:
1002-2600(2019)01-0006-04
作者:
熊紅萍 徐 靜 周 強 吳埼淇1 甘國翔2 陳忠山2
廈門大學(xué)附屬福州第二醫(yī)院內(nèi)分泌科(福州 350007)
Author(s):
XIONG Hongping; XV Jing; ZHOU Qiang; WU Qiqi; GAN Guoxiang; CHEN Zhongshan.
Department of Endocrinology,the Affiliated Fuzhou Municipal Second Hospital, Xiamen University,Fuzhou, Fujian 350007, China
關(guān)鍵詞:
糖尿病;  胃泌素;  胰高血糖素;  腸道菌群
Keywords:
diabetes mellitus;  gastrin;  glucagon;  enterobacteria
分類號:
R587.1
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討鹽酸小檗堿對2型糖尿病患者胃泌素、胰高血糖素及腸道菌群的影響。方法 選擇我院單用胰島素治療的2型糖尿病患者25例為治療組,選取同期體檢中心體檢健康人群10例為對照組。治療組根據(jù)血糖情況調(diào)整胰島素劑量,同時給予鹽酸小檗堿每次500 mg,tid,連續(xù)12周。分別于0、4、8、12周檢測血糖、胃泌素、胰高血糖素,于0、12周采集清晨空腹糞便進(jìn)行糞便菌群培養(yǎng)。結(jié)果 治療組治療前后胃泌素水平均明顯高于對照組(P<0.01); 治療組治療后胃泌素水平高于0周水平(P<0.01)。治療組治療前后胰高血糖素明顯高于對照組(P<0.01),治療前后差異無統(tǒng)計學(xué)意義(P>0.05)。治療組治療前厚壁菌門高于治療后及對照組水平(P<0.05); 治療組治療前乳酸桿菌屬、擬桿菌屬明顯低于治療后水平(P<0.05); 治療組治療前擬桿菌屬、柔嫩梭菌屬低于對照組水平(P<0.05)。結(jié)論 2型糖尿病患者存在胃腸激素及腸道菌群失調(diào),鹽酸小檗堿有助于改善糖尿病患者胃腸激素、腸道菌群失調(diào)現(xiàn)象。
Abstract:
Objective To explore the effect of berberine on gastrin(GAS), glucagon(GLC)and intestinal flora of type 2 diabetes mellitus(T2DM). Methods The T2DM patients with insulin were taken as the treatment group, while other ten healthy people were taken as the control group.The T2DM patients received adjustive insulin dose treatments according to the blood glucose condition with berberine(500 mg,tid)for twelve weeks.The level of their blood glucose, GAS, GLC were tested at 0,4,8,12 week respectively.In addition, the faeces were collected to breed fecal flora at 0,12 week. Results The GAS of treatment group was significantly higher than that of the control group(P<0.01), which was higher than that in 0 week(P<0.01).After treatment,the glucagon of treatment group was significantly higher than that of the control group(P<0.01).The firmicutes of treatment group declined(P<0.05), while the lactobacillus and bacteroides increased(P<0.05). The bacteroides and clostridium leptum of treatment group were lower than those of the control group(P<0.05).Conclusion The T2DM patients have gastrointestinal hormones and intestinal flora disorders, berberine has an effect on them.

參考文獻(xiàn)/References:

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[2] Suarez-Pinzon W L, Lakey J R T, Brand S J, et al. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass[J]. Journal of Clinical Endocrinology & Metabolism, 2005, 90(6):3401-3409.
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備注/Memo

備注/Memo:
基金項目:福州市衛(wèi)生計生系統(tǒng)科技計劃項目(2015-S-wt2); 福建省中青年骨干科技計劃項目(2015-ZQN-JC-37)1 廈門大學(xué); 2 福建中醫(yī)藥大學(xué)
更新日期/Last Update: 2019-01-20