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[1]胡夢蓉 謝文欽 江長城.右美托咪定和丙泊酚在結(jié)腸癌根治術(shù)麻醉中的應(yīng)用效果比較[J].福建醫(yī)藥雜志,2018,40(06):32-34.
　HU Mengrong,XIE Wenqin,JIANG Changcheng..Effect of dexmedetomidine and propofol anesthesia in the surgical anesthesia of colon cancer[J].FUJIAN MEDICAL JOURNAL,2018,40(06):32-34.
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右美托咪定和丙泊酚在結(jié)腸癌根治術(shù)麻醉中的應(yīng)用效果比較()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
40
期數(shù):
2018年06期
頁碼:
32-34
欄目:
臨床研究
出版日期:
2018-11-29

文章信息/Info

Title:
Effect of dexmedetomidine and propofol anesthesia in the surgical anesthesia of colon cancer
文章編號:
1002-2600(2018)06-0032-04
作者:
胡夢蓉 謝文欽 江長城
福建醫(yī)科大學(xué)附屬泉州第一醫(yī)院麻醉科(泉州 362000)
Author(s):
HU Mengrong;  XIE Wenqin; JIANG Changcheng.
Department of Anesthesiology,First Hospital in Quanzhou City of Fujian Medical University,Quanzhou,Fujian 362000,China
關(guān)鍵詞:
右美托咪定;  丙泊酚;  結(jié)腸癌根治術(shù);  鎮(zhèn)痛鎮(zhèn)靜
Keywords:
dexmedetomidine;  propofol;  radical resection of colon cancer;  soothing calm
分類號:
R753.3+5
文獻標志碼:
B
摘要:
目的 比較右美托咪定和丙泊酚在結(jié)腸癌根治術(shù)麻醉中的應(yīng)用效果。方法 全麻下行結(jié)腸癌根治術(shù)患者60例,隨機分為兩組,30例患者以右美托咪定(觀察組)鎮(zhèn)痛鎮(zhèn)靜,30例術(shù)中給予丙泊酚(對照組)維持鎮(zhèn)痛鎮(zhèn)靜。觀察組給以靜脈泵注0.6 μg/kg右美托咪定,20 min后,速度調(diào)至0.4 μg/kg,距手術(shù)結(jié)束30 min停止使用。對照組給以靜脈泵注2.5 mg/kg丙泊酚,手術(shù)結(jié)束前10 min停止使用丙泊酚。術(shù)中對兩組患者給藥前(T1)、誘導(dǎo)前(T2)、插管前即刻(T3)、插管成功1 min(T4)、切皮(T5)、手術(shù)牽拉(T6)、拔管后(T7)的心率(HR)、呼吸頻率(RR)及平均動脈壓(MAP)進行觀察記錄,并對兩組患者瑞芬太尼和七氟醚的用量及術(shù)后1、4 h的鎮(zhèn)痛鎮(zhèn)靜效果進行比較。結(jié)果 觀察組T2～T7時HR和MAP顯著低于對照組,且觀察組術(shù)中使用瑞芬太尼及七氟醚的藥量對比對照組結(jié)果為顯著降低,術(shù)后觀察組的鎮(zhèn)痛鎮(zhèn)靜效果比對照組更加理想(均P<0.05)。結(jié)論 右美托咪定在結(jié)腸癌根治術(shù)中的鎮(zhèn)痛鎮(zhèn)靜效果明顯優(yōu)于丙泊酚,能使患者的應(yīng)激反應(yīng)明顯降低,并且減少瑞芬太尼及七氟醚的使用量,提高了手術(shù)后的鎮(zhèn)痛鎮(zhèn)靜效果。
Abstract:
Objective To compare the effect of dexmedetomidine and propofol in the surgical anesthesia of colon cancer.Methods Sixty patients were treated with radical resection of colon cancer under general anesthesia, and were divided into two groups by random lottery. Thirty patients were treated with dexmedetomidine(observation group)for analgesic and sedation, and thirty patients were treated with propofol(control group)for maintenance analgesic and sedation. In the observation group, patients were given 0.6 μg/kg dexmedetomidine by intravenous injection,after 20 minutes, the velocity was adjusted to 0.4 μg/kg and the use was discontinued 30 minutes after the operation. In the control group,patients were given 2.5 mg/kg propofol by intravenous pump injection, and the use was stopped 10 minutes before the operaticon.Before dosing(T1), before the induction(T2), immediately before intubation(T3), 1 min successful intubation(T4), cut skin(T5), surgery pull(T6), after extubation(T7)of patients in two groups of fentanyl and sevoflurane and postoperative analgesia sedative effects of 1,4 h were compared in the two groups. Results HR and MAP of the observation group were significantly lower than those of the control group from T2 to T7, and the intraoperative dose of remifentanil and sevoflurane in the observation group was significantly lower than that in the control group, the analgesia and sedation effect of the observation group was more ideal than that of the control group(all above P<0.05). Conclusion The analgesic and sedation effect of dexmedetomidine in the radical operation of colon cancer is obviously superior to propofol, which can significantly reduce the stress response of patients, reduce the use of remifentanil and sevoflurane, and improve the analgesic and sevoflurane after operation.

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更新日期/Last Update: 2018-11-29