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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:

47

期數(shù):

2025年01期

頁碼:

77-80101

欄目:

基礎(chǔ)研究

出版日期:

2025-01-20

文章信息/Info

Title:

Study on effects of propofol on depressive-like behaviors and learning-memory in depressive model mice

文章編號:

1002-2600(2025)01-0077-05

作者:

陳峰

福建省福州市長樂區(qū)人民醫(yī)院麻醉科,福州 350200

Author(s):

CHEN Feng

Department of Anesthesiology, Changle District People's Hospital, Fuzhou, Fujian 350200, China

關(guān)鍵詞:

丙泊酚;  抑郁癥模型;  抑郁樣行為;  學(xué)習(xí)記憶

Keywords:

propofol;  depressive model;  depressive-like behavior;  learning-memory

分類號:

R74

DOI:

10.20148/j.fmj.2025.01.024

文獻標(biāo)志碼:

A

摘要:

目的 探究丙泊酚對抑郁癥模型小鼠抑郁樣行為及學(xué)習(xí)記憶功能的影響。方法 取40只抑郁癥模型小鼠,按照干預(yù)方法不同分為抑郁模型組和丙泊酚低劑量組(50 mg/kg)、中劑量組(75 mg/kg)、高劑量組(100 mg/kg),每組10只; 另取10只正常小鼠,設(shè)為正常對照組。丙泊酚低、中、高劑量組小鼠腹腔注射丙泊酚,抑郁模型組、正常對照組小鼠給予等容量生理鹽水腹腔注射。丙泊酚注射24 h后進行懸尾實驗、強迫游泳實驗和糖水偏好測試,間隔7 d后各組重新進行相應(yīng)的藥物(丙泊酚或生理鹽水)處理,24 h后進行Morris水迷宮測試。結(jié)果 抑郁模型組小鼠在懸尾狀態(tài)和強迫游泳實驗下靜止時間均高于正常對照組,丙泊酚低、中、高劑量組小鼠在懸尾狀態(tài)和強迫游泳實驗下靜止時間均低于抑郁模型組; 抑郁模型組小鼠糖水消耗百分比低于對照組,丙泊酚低、中、高劑量組小鼠糖水消耗百分比均高于抑郁模型組; 抑郁模型組小鼠逃避潛伏時間高于對照組,丙泊酚低、中、高劑量組小鼠逃避潛伏時間均低于抑郁模型組; 抑郁模型組小鼠空間探索時間低于對照組,丙泊酚低、中、高劑量組小鼠空間探索時間均高于抑郁模型組。以上組間差異均有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 丙泊酚可以緩解抑郁癥小鼠的抑郁樣行為,且會改善抑郁癥小鼠的學(xué)習(xí)記憶功能。

Abstract:

Objective To investigate the effects of propofol on depressive-like behaviors and learning-memory functions in depressive model mice. Methods Forty depressive model mice were divided into a depressive model group and low-dose(50 mg/kg), medium-dose(75 mg/kg), high-dose(100 mg/kg)propofol groups according to different intervention methods, with 10 mice in each group. Another 10 normal mice were set as the normal control group. Mice in the low-dose, medium-dose, and high-dose propofol groups were intraperitoneally injected with propofol, while mice in the depressive model group and the normal control group were intraperitoneally injected with an equal volume of normal saline. Twenty-four hours after the propofol injection, the tail suspension test, forced swimming test, and sucrose preference test were carried out. After an interval of seven days, each group was re-treated with the corresponding drug(propofol or normal saline), and 24 hours later, the Morris water maze test was performed. Results The immobile time of mice in the depressive model group was higher than that in the normal control group in the tail suspension state and forced swimming test(P<0.05). The immobile time of mice in the low-, medium-, and high-dose propofol groups was lower than that in the depressive model group in the tail suspension state and forced swimming test(P<0.05). The percentage of sucrose consumption of mice in the depressive model group was lower than that in the control group(P<0.05). The percentage of sucrose consumption of mice in the low-, medium-, and high-dose propofol groups was higher than that in the depressive model group(P<0.05). The escape latency of mice in the depressive model group was higher than that in the control group(P<0.05). The escape latency of mice in the low-, medium-, and high-dose propofol groups was lower than that in the depressive model group(P<0.05). The spatial exploration time of mice in the depressive model group was lower than that in the control group(P<0.05). The spatial exploration time of mice in the low-, medium-, and high-dose propofol groups was higher than that in the depressive model group(P<0.05). Conclusion Propofol can alleviate the depressive-like behaviors of depressive mice and improve the learning-memory functions of depressive mice.

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更新日期/Last Update: 2025-01-20