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[1]李露,張令歌,張喬娜,等.殼多糖酶-3樣蛋白1在終末期腎病患者失功自體動靜脈內(nèi)瘺組織中的表達及作用機制[J].福建醫(yī)藥雜志,2024,46(08):5-9.[doi:10.20148/j.fmj.2024.08.002]
　LI Lu,ZHANG Lingge,ZHANG Qiaona,et al.Expression of CHI3L1 in failed autologous arteriovenous fistula of patients with end-stage renal disease and its mechanism of action[J].FUJIAN MEDICAL JOURNAL,2024,46(08):5-9.[doi:10.20148/j.fmj.2024.08.002]
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殼多糖酶-3樣蛋白1在終末期腎病患者失功自體動靜脈內(nèi)瘺組織中的表達及作用機制()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年08期
頁碼:
5-9
欄目:
臨床研究
出版日期:
2024-12-20

文章信息/Info

Title:
Expression of CHI3L1 in failed autologous arteriovenous fistula of patients with end-stage renal disease and its mechanism of action
文章編號:
1002-2600(2024)08-0005-05
作者:
李露1; 張令歌1; 張喬娜1; 王紅茹1; 衣利2
1 西安醫(yī)學院第一附屬醫(yī)院腎內(nèi)科,西安 710077; 2 陜西省西安市長安醫(yī)院腎內(nèi)科,西安 710016
Author(s):
LI Lu1; ZHANG Lingge1; ZHANG Qiaona; WANG Hongru1; YI Li2
1 Department of Nephrology, the First Affiliated Hospital, Xi'an Medical University, Xi'an,Shanxi 710077, China; 2 Department of Nephrology, Chang'an Hospital, Xi'an,Shanxi 710016, China
關鍵詞:
腎臟替代治療;  血液透析;  自體動靜脈內(nèi)瘺;  殼多糖酶-3樣蛋白1
Keywords:
renal replacement therapy;  hemodialysis;  autologous arteriovenous fistula;  chitinase-3-like protein 1
分類號:
R692.5
DOI:
10.20148/j.fmj.2024.08.002
文獻標志碼:
B
摘要:
目的 探討殼多糖酶-3樣蛋白1(CHI3L1)在終末期腎病患者自體動靜脈內(nèi)瘺(AVF)組織中的表達,分析其在AVF失功中的潛在作用機制。方法 收集了9例因終末期腎病行前臂AVF成形術,或因血管瘺狹窄致AVF失功而行重建術患者的術中血管組織,采用免疫組織化學法檢測局部組織中CHI3L1、基質金屬蛋白酶9(MMP-9)、基質金屬蛋白酶2(MMP-2)和血管內(nèi)皮生長因子-A(VEGF-A)的表達情況。結果 因狹窄導致的失功AVF組織表現(xiàn)為腔內(nèi)血栓、膠原纖維破裂、纖維結締組織增生、管壁增厚及新生血管形成、中膜層的散在炎癥細胞浸潤及局部CHI3L1表達量增高,其中,初次建立AVF組CHI3L1陽性面積率中位數(shù)為0.42,因血管瘺狹窄致AVF失功行AVF重建術組CHI3L1陽性面積率中位數(shù)0.64,差異有統(tǒng)計學意義(P<0.05); AVF重建組MMP-2和VEGF-A的表達水平升高,且CHI3L1與MMP-2、MMP-9及VEGF-A表達水平呈正相關(r=0.902 2,P<0.05; r=0.932 3,P<0.001; r=0.833 5,P<0.05)。結論 血管組織中CHI3L1的表達可能在AVF失功中起重要作用。MMP-9、MMP-2和VEGF-A可能參與了CHI3L1導致的血管狹窄。
Abstract:
Objective To investigate the expression of CHI3L1 in autologous arteriovenous fistula(AVF)in patients with end-stage renal disease and to analyze the potential mechanism of CHI3L1 in AVF failure.Methods Immunoreactivity of CHI3L1, matrix metalloproteinase 9(MMP-9), matrix metalloproteinase 2(MMP-2)and vascular endothelial growth factor-A(VEGF-A)were detected in vascular tissues collected from nine patients who underwent AVF surgery.Due to significant stenosis, six of the nine patients received arteriovenous fistula reconstruction.Results The failure of AVF due to stenosis was characterized by intracaval thrombosis, collagen fiber rupture, fibrous connective tissue hyperplasia, vessel wall thickening and neovascularization, scattered inflammatory cell infiltration and increased CHI3L1 expression.The median CHI3L1 positive area rate in the initial AVF group was 0.42, and was 0.64 in the AVF reconstruction group due to vascular fistula stenosis. The difference was statistically significant(P<0.05).The expression levels of MMP-2 and VEGF-A increased in the AVF reconstruction group.The expression of CHI3L1 was positively correlated with MMP-2, MMP-9 and VEGF-A(r=0.902 2, P<0.05; r=0.9323, P<0.001; r=0.8335, P<0.05).Conclusion CHI3L1 expression in vascular tissues possibly plays an important role in AVF failure.MMP-2 and VEGF-A may participate in venous stenosis with CHI3L1.

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備注/Memo

備注/Memo:
基金項目:陜西省西安市2022年科技計劃項目(22YXYJ0147)
通信作者:衣 利,Email:[email protected]
更新日期/Last Update: 2024-12-20