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[1]余聰,陳名峰,丁昕,等.事件相關(guān)電位P3b成分在帕金森病認(rèn)知障礙診斷中的應(yīng)用[J].福建醫(yī)藥雜志,2024,46(07):1-4.[doi:10.20148/j.fmj.2024.07.001]
　YU Cong,CHEN Mingfeng,DING Xin,et al.Application of P3b component of event-related potentials in diagnosis of cognitive impairment in Parkinson's disease[J].FUJIAN MEDICAL JOURNAL,2024,46(07):1-4.[doi:10.20148/j.fmj.2024.07.001]
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事件相關(guān)電位P3b成分在帕金森病認(rèn)知障礙診斷中的應(yīng)用()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年07期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2024-11-20

文章信息/Info

Title:
Application of P3b component of event-related potentials in diagnosis of cognitive impairment in Parkinson's disease
文章編號:
1002-2600(2024)07-0001-04
作者:
余聰; 陳名峰; 丁昕; 葉云珺; 陳培瓊
福州大學(xué)附屬省立醫(yī)院神經(jīng)內(nèi)科,福州 350001
Author(s):
YU Cong;  CHEN Mingfeng;  DING Xin;  YE Yunjun;  CHEN Peiqiong
Department of Neurology, Affiliated Provincial Hospital of Fuzhou University, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
帕金森病;  認(rèn)知障礙;  事件相關(guān)電位;  P3b
Keywords:
Parkinson's disease;  cognitive impairment;  event-related potential;  P3b
分類號:
R742.5
DOI:
10.20148/j.fmj.2024.07.001
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討事件相關(guān)電位P3b成分在帕金森病(PD)認(rèn)知障礙診斷的應(yīng)用價(jià)值。方法 比較PD組和健康對照組P3b指標(biāo)的差異,評估P3b指標(biāo)與PD組的臨床資料及認(rèn)知障礙的依存關(guān)系。結(jié)果 帕金森病癡呆(PDD)組的P3b潛伏期較帕金森病輕度認(rèn)知障礙(PD-MCI)組延長(P<0.05),較健康對照組和帕金森病認(rèn)知正常(PD-CN)組明顯延長(P<0.01)。PD組的P3b潛伏期與蒙特利爾認(rèn)知評估(MoCA)評分呈負(fù)相關(guān)(r=-0.506,P<0.01),視空間與執(zhí)行力、延遲回憶對P3b潛伏期產(chǎn)生負(fù)向影響(t=-4.775,P<0.01; t=-2.186,P<0.05)。PD組的P3b潛伏期與年齡、Hoehn-Yahr分級、UPDRS-Ⅲ評分呈正相關(guān)(r=0.191,P<0.05; r=0.262,P<0.01; r=0.218,P<0.05),與受教育年限呈負(fù)相關(guān)(r=-0.340,P<0.01); PD組的P3b潛伏期與性別、帕金森病病程無明顯的相關(guān)關(guān)系(r=0.041,P>0.05; r=0.084,P>0.05)。結(jié)論 認(rèn)知損害越嚴(yán)重,P3b潛伏期越長,P3b潛伏期可以作為PD認(rèn)知障礙的量化指標(biāo),對于早期識別PD認(rèn)知障礙有意義。
Abstract:
Objective To explore the application value of P3b component of event-related potentials in the diagnosis of cognitive impairment of Parkinson's disease(PD)patients.Methods The difference in P3b indicators between PD group and healthy control group was compared, and the dependence relationship of P3b indicator on clinical data and cognitive impairment in the PD group was evaluated.Results The P3b latency of Parkinson's disease dementia(PDD)group was longer than that of PD mild cognitive impairment(PD-MCI)group(P<0.05), and significantly longer than that of the healthy control group and PD normal cognition(PD-CN)group(P<0.01).The P3b latency of the PD group was negatively correlated with the Montreal cognitive assessment(MoCA)score(r=-0.506, P<0.05), visuospatial and executive functions and delayed recall had negative impact on the P3b latency(t=-4.775, P<0.01; t=-2.186, P<0.05).The P3b latency in the PD group was positively correlated with age, Hoehn Yahr grading, and UPDRS-Ⅲ score(r=0.191,P<0.05; r=0.262,P<0.01; r=0.218,P<0.05), and negatively correlated with years of education(r=-0.340, P<0.01); The P3b latency in the PD group was not significantly correlated with gender and the course of Parkinson's disease(r=0.041,P>0.05; r=0.084,P>0.05).Conclusion The more severe the cognitive impairment, the longer the P3b latency.P3b latency can serve as a quantitative indicator of PD cognitive impairment, which is meaningful for early identification of PD cognitive impairment.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省衛(wèi)健委科技計(jì)劃項(xiàng)目青年科研課題(2021QNA010 ); 福建醫(yī)科大學(xué)啟航基金一般項(xiàng)目(2019QH1190)
通信作者:陳名峰,Email: [email protected]
更新日期/Last Update: 2024-11-20