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[1]陳劍明,陳國平.UCNPs@mSiO2-PEG納米材料的構(gòu)建及其細(xì)胞靶性研究[J].福建醫(yī)藥雜志,2024,46(06):74-77.[doi:10.20148/j.fmj.2024.06.023]
　CHEN Jianming,CHEN Guoping.Construction of UCNPs@mSiO2-PEG nanomaterials and cellular targeting ability[J].FUJIAN MEDICAL JOURNAL,2024,46(06):74-77.[doi:10.20148/j.fmj.2024.06.023]
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UCNPs@mSiO2-PEG納米材料的構(gòu)建及其細(xì)胞靶性研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年06期
頁碼:
74-77
欄目:
基礎(chǔ)研究
出版日期:
2024-11-15

文章信息/Info

Title:
Construction of UCNPs@mSiO2-PEG nanomaterials and cellular targeting ability
文章編號(hào):
1002-2600(2024)06-0074-04
作者:
陳劍明; 陳國平
福建省福州市第二總醫(yī)院,福州 350007
Author(s):
CHEN Jianming;  CHEN Guoping
Fuzhou Second General Hospital, Fuzhou, Fujian 350007, China
關(guān)鍵詞:
上轉(zhuǎn)換材料;  納米粒子;  結(jié)腸癌
Keywords:
upconversion materials;  nanoparticles;  colon cancer
分類號(hào):
R73
DOI:
10.20148/j.fmj.2024.06.023
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 制備UCNPs@mSiO2-PEG納米材料并考察其靶向結(jié)腸癌CT26細(xì)胞的能力。 方法 采用介孔二氧化硅包覆在上轉(zhuǎn)換材料(UCNPs)來制備核-殼結(jié)構(gòu)納米粒子(UCNPs@mSiO2),在其表面進(jìn)行聚乙二醇(PEG)改性,通過X射線衍射(XRD)和透射電子顯微鏡(TEM)對(duì)構(gòu)建的UCNPs@mSiO2-PEG納米材料進(jìn)行表征,并通過激光共聚焦拍照觀察其靶向結(jié)腸癌CT26細(xì)胞的能力。結(jié)果 UCNPs@mSiO2-PEG在2θ～22°處出現(xiàn)無定形SiO2特征衍射峰; UCNPs@mSiO2-PEG納米粒子呈單個(gè)分散圓球形,SiO2薄膜層覆蓋在UCNPs納米粒子的表面,PEG改性層進(jìn)一步覆蓋在SiO2薄膜層上; 發(fā)出綠色熒光的UCNPs@mSiO2-PEG載體圍繞在結(jié)腸癌CT26細(xì)胞周圍。結(jié)論 成功構(gòu)建核-殼結(jié)構(gòu)納米粒子UCNPs@mSiO2并進(jìn)行了表面改性,改性后的UCNPs@mSiO2-PEG納米粒子能有效靶向結(jié)腸癌CT26細(xì)胞。
Abstract:
Objective To prepare UCNPs@mSiO2-PEG nanomaterials and investigate their ability to target colon cancer CT26 cells. Methods Mesoporous silica was coated on upconversion materials to prepare coreshell structured nanoparticles(UCNPs@mSiO2). Polyethylene glycol(PEG)modification was carried out on its surface.The constructed UCNPs@mSiO2-PEG nanomaterials were characterized by X-ray diffraction(XRD)and transmission electron microscopy(TEM). The ability to target colon cancer CT26 cells was observed by laser confocal photography. Results UCNPs@mSiO2-PEG showed an amorphous SiO2 characteristic diffraction peak at 2θ～22°. UCNPs@mSiO2-PEG nanoparticles were in a single dispersed spherical shape. The SiO2 film layer covered the surface of UCNPs nanoparticles, and the PEG modification layer further covered the SiO2 film layer. The UCNPs@mSiO2-PEG carrier emitting green fluorescence surrounded the colon cancer CT26 cells. Conclusion The coreshell structured nanoparticles UCNPs@mSiO2 were successfully constructed and surface-modified. The modified UCNPs@mSiO2-PEG nanoparticles can effectively target colon cancer CT26 cells.

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備注/Memo

備注/Memo:
基金項(xiàng)目:福建省自然科學(xué)基金資助項(xiàng)目(2022J011314)
通信作者:陳國平,Email:[email protected]
更新日期/Last Update: 2024-11-15