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[1]張曉芬,吳世忠,魏德.海馬神經(jīng)連接蛋白-2參與三叉神經(jīng)痛大鼠模型焦慮樣行為[J].福建醫(yī)藥雜志,2024,46(06):71-74.[doi:10.20148/j.fmj.2024.06.022]
　ZHANG Xiaofen,WU Shizhong,WEI De.Hippocampal Neuroligin-2 is involved in anxiety-like behavior in a rat model of trigeminal neuralgia[J].FUJIAN MEDICAL JOURNAL,2024,46(06):71-74.[doi:10.20148/j.fmj.2024.06.022]
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海馬神經(jīng)連接蛋白-2參與三叉神經(jīng)痛大鼠模型焦慮樣行為()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年06期
頁碼:
71-74
欄目:
基礎(chǔ)研究
出版日期:
2024-11-15

文章信息/Info

Title:
Hippocampal Neuroligin-2 is involved in anxiety-like behavior in a rat model of trigeminal neuralgia
文章編號(hào):
1002-2600(2024)06-0071-04
作者:
張曉芬1; 吳世忠2; 魏德2
1 廈門醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)部人體解剖學(xué)與組織胚胎學(xué)教研室,廈門 361000; 2 福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院神經(jīng)外科,福州 350001
Author(s):
ZHANG Xiaofen1;  WU Shizhong2;  WEI De2
1 Department of Human Anatomy and Embryology, Basic Medical Science, Xiamen Medical College, Xiamen, Fujian 361000, China; 2 Department of Neurosurgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 35
關(guān)鍵詞:
三叉神經(jīng)痛;  腹側(cè)海馬;  痛焦慮;  星形膠質(zhì)細(xì)胞;  神經(jīng)連接蛋白
Keywords:
trigeminal neuralgia;  ventral hippocampus;  anxiety-like pain;  astrocytes;  neuroligin-2
分類號(hào):
R3; R749.7+2
DOI:
10.20148/j.fmj.2024.06.022
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 研究在三叉神經(jīng)痛(TN)大鼠腹側(cè)海馬的神經(jīng)連接蛋白-2(Neuroligin-2)表達(dá)變化及其在星形膠質(zhì)細(xì)胞的表達(dá)情況。方法 通過大鼠三叉神經(jīng)根(TREZ)慢性壓迫損傷誘導(dǎo)建立TN動(dòng)物模型,應(yīng)用纖毛機(jī)械刺激針測大鼠口面部機(jī)械痛閾值、曠場實(shí)驗(yàn)、高架十字迷宮測定動(dòng)物焦慮水平、自主活動(dòng)情況。術(shù)后21 d取材,采用免疫熒光染色以及蛋白質(zhì)印跡檢測腹側(cè)海馬Neuroligin-2的表達(dá)變化。結(jié)果 經(jīng)TREZ慢性壓迫損傷后,TN大鼠具有焦慮樣行為表現(xiàn),腹側(cè)海馬的A1型星形膠質(zhì)細(xì)胞被大量激活,并誘導(dǎo)其來源的Neuroligin-2表達(dá)增多。結(jié)論 大鼠TREZ慢性壓迫激活可誘導(dǎo)星形膠質(zhì)細(xì)胞來源的Neuroligin-2表達(dá)增多,可能通過改變海馬神經(jīng)元興奮性和抑制性突觸比例,參與焦慮樣行為的產(chǎn)生。
Abstract:
Objective To investigate the expression of Neuroligin-2 and its expression in astrocytes in the ventral hippocampus of trigeminal neuralgia(TN)rats. Methods Trigeminal nerve root entry zone(TREZ)chronic compression injury was used to induce TN animal model. Orofacial mechanical pain threshold was measured by von Frey, open field test and elevated plus maze were used to measure autonomic activity. Immunofluorescence staining and Western blot were used to detect the expression of Neuroligin-2 in the ventral hippocampus at 21 days after operation. Results TN rats showed anxiety-like behavior after chronic compression injury with TREZ. A1 astrocytes in the ventral hippocampus were heavily activated and the expression of astrocyte-derived Neuroligin-2 was induced. Conclusion Chronic compression and activation of TREZ in rats can induce increased expression of astrocyte-derived Neuroligin-2, which may be involved in the generation of anxiety-like behavior by changing the ratio of excitatory and inhibitory synapses of hippocampal neurons.

參考文獻(xiàn)/References:

[1] HALFF E F, HANNAN S, KWANTHONGDEE J, et al. Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization[J]. Sci Signal, 2022, 15(739): 2505.
[2] ALI H, MARTH L, KRUEGER-BURG D. Neuroligin-2 as a central organizer of inhibitory synapses in health and disease[J]. Sci Signal, 2020, 13(663): 8379.
[3] GHISLAIN B, RABINSTEIN A A, BRAKSICK S A. Etiolo-gies and Utility of Diagnostic Tests in Trigeminal Neuropathy[J]. Mayo Clin Proc, 2022, 97(7): 1318-1325.
[4] LV X J, LV S S, WANG G H, et al. Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia[J]. Brain Behav Immun, 2024, 117: 224-241.
[5] LV S S, LV X J, CAI Y Q, et al. Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit[J]. Sci Adv, 2024, 10(3): 4196.
[6] JIMENEZ J C, SU K, GOLDBERG A R, et al. Anxiety Cells in a Hippocampal-Hypothalamic Circuit[J]. Neuron, 2018, 97(3): 670-683.
[7] CHENG T, XU Z, MA X. The role of astrocytes in neuropathic pain[J]. Front Mol Neurosci, 2022, 15: 1007889.
[8] 李秋華. 星形膠質(zhì)細(xì)胞Neuroligin-2對大鼠三叉神經(jīng)根慢性壓迫損傷的研究[D]. 福州: 福建醫(yī)科大學(xué), 2020.
[9] WU T H, HU L Y, LU T, et al. Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study[J]. J Headache Pain, 2015, 16: 64.
[10] BEMBEN M A, SHIPMAN S L, NICOLL R A, et al. The cellular and molecular landscape of neuroligins[J]. Trends Neurosci, 2015, 38(8): 496-505.
[11] LI J, HAN W, PELKEY K A, et al. Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development[J]. Neuron, 2017, 96(4): 808-826.
[12] HINTON T, JOHNSTON G A R. GABA-enriched teas as neuro-nutraceuticals[J]. Neurochem Int, 2020, 141: 104895.
[13] ALI H, MARTH L, KRUEGER-BURG D. Neuroligin-2 as a central organizer of inhibitory synapses in health and disease[J]. Sci Signal, 2020, 13(663): 8379.
[14] CRUCCU G, DI STEFANO G, TRUINI A. Trigeminal Neuralgia[J]. N Engl J Med, 2020, 383(8): 754-762.
[15] REISS J, LENZ U, AQUAVIVA-BOURDAIN C, et al. A GPHN point mutation leading to molybdenum cofactor deficiency[J]. Clin Genet, 2011, 80(6): 598-599.

備注/Memo

備注/Memo:
基金項(xiàng)目:福建省衛(wèi)生教育聯(lián)合攻關(guān)計(jì)劃項(xiàng)目(2019-WJ-26)
通信作者:魏 德,Email: [email protected]
更新日期/Last Update: 2024-11-15