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[1]侯志婷,林毅勝,丁培燕,等.泉州地區(qū)獻(xiàn)血人群ABO、Rh血型分布特點分析[J].福建醫(yī)藥雜志,2024,46(06):14-17.[doi:10.20148/j.fmj.2024.06.004]
　HOU Zhiting,LIN Yisheng,DING Peiyan,et al.Distribution of ABO and Rh blood group among blood donors in Quanzhou[J].FUJIAN MEDICAL JOURNAL,2024,46(06):14-17.[doi:10.20148/j.fmj.2024.06.004]
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泉州地區(qū)獻(xiàn)血人群ABO、Rh血型分布特點分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年06期
頁碼:
14-17
欄目:
臨床研究
出版日期:
2024-11-15

文章信息/Info

Title:
Distribution of ABO and Rh blood group among blood donors in Quanzhou
文章編號:
1002-2600(2024)06-0014-04
作者:
侯志婷; 林毅勝; 丁培燕; 陳嚇燕; 黃小靜; 章永明
福建省泉州市中心血站,泉州 362000
Author(s):
HOU Zhiting;  LIN Yisheng;  DING Peiyan;  CHEN Xiayan;  HUANG Xiaojing;  ZHANG Yongming
Quanzhou Central Blood Station, Quanzhou, Fujian 362000, China
關(guān)鍵詞:
ABO血型;  Rh血型;  血型分布;  基因頻率;  泉州
Keywords:
ABO blood group;  Rh blood group;  blood group distribution;  allelic frequency;  Quanzhou
分類號:
R457.1+1
DOI:
10.20148/j.fmj.2024.06.004
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討泉州地區(qū)獻(xiàn)血人群ABO和Rh血型分布特點,豐富稀有表型資料庫,以期指導(dǎo)采供血計劃和無償獻(xiàn)血者招募策略的制訂,保障泉州地區(qū)的臨床用血。方法 收集2018—2022年泉州市190 195名獻(xiàn)血者數(shù)據(jù),分析其ABO和RhD血型分布特點,進(jìn)行ABO血型Hardy-Weinberg吻合度檢驗,并對2022年8月至2024年4月本站RhD陰性標(biāo)本進(jìn)行RhC、c、E、e抗原分型檢測,建立稀有表型資料庫。結(jié)果 泉州地區(qū)獻(xiàn)血人群ABO表現(xiàn)型O>A>B>AB,基因頻率r>p>q,期望值與觀察值差異有統(tǒng)計學(xué)意義,不符合Hardy-Weinberg遺傳規(guī)律。漢族RhD陰性獻(xiàn)血者占比0.44%,271名RhD陰性獻(xiàn)血者中,共檢出6種表現(xiàn)型:ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee; 未檢出CcdEE、ccdEE、CCdEE、CCdEe,2例未檢出C(c)抗原,RhC、c、E、e抗原頻率由高到低均為e>c>C>E。結(jié)論 血型遺傳規(guī)律不能真實反映獻(xiàn)血人群的血型分布,根據(jù)研究所得的獻(xiàn)血人群ABO和Rh血型分布特點可用來指導(dǎo)制訂采供血計劃和精準(zhǔn)的無償獻(xiàn)血者招募策略,保障本地區(qū)的血液供應(yīng)。
Abstract:
Objective Determining the distribution of ABO and Rh phenotypes among blood donors in Quanzhou and enriching the rare phenotype database will allow us to ensure better management of blood stocks and good recruitment strategies for supplying Quanzhou with blood products. Methods The data of 190 195 blood donors in Quanzhou from 2018 to 2022 were collected to analyze the ABO and RhD blood group distribution characteristics, and the ABO blood group were performed Hardy-Weinberg equilibrium test; RhC, c, E and e antigen typing detections were performed on RhD-negative individuals from August 2022 to April 2024 to establish a rare phenotype database. Results O>A>B>AB and r>p>q in our blood donors were noticed. The differences between expected frequency and observed frequency were statistically significant which didnt accord with Hardy-Weinberg equilibrium rules. The frequency of RhD-Negative in Han nationality blood donors was 0.44%. We found 6 phenotypes among 271 RhD negative blood donors: ccdee>Ccdee>CCdee>ccdEe>CcdEe>--dee; no CcdEE, ccdEE, CCdEE, CCdEe were detected, and no C(c)antigen was detected in 2 cases. The frequency of RhC, c, E, e antigens was e>c>C>E respectively. Conclusion The genetic rules of blood group can not truly reflect the blood group distribution of blood donors. The ABO and Rh blood group distribution characteristics of blood donors obtained in this study can be used to guide the development of blood procurement plans and accurate recruitment strategies for blood donors, so as to ensure the blood supply in our region.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項目:泉州市科技計劃項目(2022NS038)
通信作者:林毅勝,Email: [email protected]
更新日期/Last Update: 2024-11-15