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[1]張紹潔,閻國輝,甘書芬.冠狀動脈Z值等四聯(lián)指標模型對黏膜皮膚淋巴結綜合征的輔助診斷價值[J].福建醫(yī)藥雜志,2024,46(04):13-17.[doi:10.20148/j.fmj.2024.04.004]
　ZHANG Shaojie,YAN Guohui,GAN Shufen.Auxiliary diagnostic value of coronary artery Z-value and other quadruple index model for mucocutaneous lymph node syndrome[J].FUJIAN MEDICAL JOURNAL,2024,46(04):13-17.[doi:10.20148/j.fmj.2024.04.004]
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冠狀動脈Z值等四聯(lián)指標模型對黏膜皮膚淋巴結綜合征的輔助診斷價值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年04期
頁碼:
13-17
欄目:
臨床研究
出版日期:
2024-08-15

文章信息/Info

Title:
Auxiliary diagnostic value of coronary artery Z-value and other quadruple index model for mucocutaneous lymph node syndrome
文章編號:
1002-2600(2024)04-0013-05
作者:
張紹潔; 閻國輝; 甘書芬
廈門大學附屬中山醫(yī)院超聲科,廈門 361004
Author(s):
ZHANG Shaojie; YAN Guohui; GAN Shufen
Department of Ultrasound,Zhongshan Hospital Xiamen University,Xiamen,Fujian 361004,China
關鍵詞:
黏膜皮膚淋巴結綜合征;  冠狀動脈;  Z值;  發(fā)熱時間;  白細胞介素-6;  C反應蛋白
Keywords:
mucocutaneous lymph node syndrome;  coronary artery;  Z value;  febrile duration;  interleukin-6;  C-reactive protein
分類號:
R445.1; R725.4
DOI:
10.20148/j.fmj.2024.04.004
文獻標志碼:
B
摘要:
目的 探討冠狀動脈Z值聯(lián)合發(fā)熱時間、白細胞介素-6(IL-6)、C反應蛋白(CRP)四聯(lián)指標模型對黏膜皮膚淋巴結綜合征(又稱“川崎病”)的輔助診斷價值。方法 選取2017年1月至2022年12月廈門大學附屬中山醫(yī)院兒科收治的懷疑為川崎病的患兒165例,以臨床診斷標準作為金標準最終確診的83例為病例組(包括不完全川崎病),排除川崎病診斷的82例為對照組。收集患兒的臨床資料和冠脈Z值,采用多因素logistic回歸分析發(fā)病的獨立危險因素,構建川崎病四聯(lián)指標模型。繪制受試者工作特征曲線(ROC曲線),計算曲線下面積(AUC),用約登指數(shù)確定最佳診斷閾值。用Kappa值評價四聯(lián)指標模型與臨床診斷標準的一致性。結果 冠脈Z值、發(fā)熱時間、IL-6、CRP是川崎病的獨立危險因素,最佳診斷閾值分別為:冠脈Z值1.5,發(fā)熱時間5.5 d,IL-6 31 pg/mL,CRP 42 mg/L。基于獨立危險因素構建的四聯(lián)指標模型AUC為0.960,Kappa值為0.867,診斷價值高于各獨立危險因素,與臨床診斷標準具有較好的一致性。結論 冠脈Z值聯(lián)合發(fā)熱時間、IL-6、CRP構建的四聯(lián)指標模型能有效地輔助臨床診斷并減少漏診,為提高KD診斷效率提供參考依據(jù)。
Abstract:
Objective To explore the auxiliary diagnostic value of coronary artery Z-value combined with febrile duration,IL-6,CRP for mucocutaneous lymph node syndrome(also known as Kawasaki disease). Methods A total of 165 suspected cases of Kawasaki disease admitted in paediatric ward of Zhongshan Hospital Xiamen University from January 2017 to December 2022 were enrolled in this study.Among the 165 cases,83 were confirmed having Kawasaki disease(including incomplete Kawasaki disease),and the other 82 cases were excluded. Clinical data and coronary artery Z-value of the children were collected. Multivariate logistic regression was used to analyze the independent risk factors. A quadruple index model for the disease was constructed. Receiver operating characteristic curve(ROC)analysis was used to calculate the area under the curve(AUC),and the optimal diagnostic threshold was determined by Youden index. Kappa value was used to evaluate the consistency between quadruple index diagnostic model and clinical diagnostic criteria. Results Coronary artery Z-value,febrile duration,IL-6,CRP were the independent risk factors of Kawasaki disease. The optimal diagnostic threshold was 1.5 for coronary artery Z-value,5.5 d for febrile duration,31 pg/mL for IL-6 and 42 mg/L for CRP. The AUC of quadruple index diagnostic model was 0.960,Kappa value was 0.867. Its diagnostic value was higher than those of independent risk factors,and it has high consistency with clinical diagnostic criteria. Conclusion Coronary artery Z-value combined with febrile duration,IL-6 and CRP quadruple index model can effectively assist clinical diagnosis and reduce missed diagnosis,and provide reference for improving the efficiency of Kawasaki disease diagnosis.

參考文獻/References:

[1] FUKAZAWA R,KOBAYASHI J,AYUSAWA M,et al. JCS/JSCS 2020 guideline on diagnosis and management of cardiovascular sequelae in Kawasaki disease[J].Circ J,2020,84(8): 1348-1407.
[2] 閆輝,杜軍保.川崎病的臨床診治探索任重道遠[J].中國實用兒科雜志,2017,32(8):561-564.
[3] 王雷,夏焙.超聲心動圖在川崎病診斷、治療及長期隨訪中的應用進展——2017年AHA指南的解讀[J/CD].中華醫(yī)學超聲雜志(電子版),2019,16(3):161-165.
[4] 中華醫(yī)學會兒科學分會心血管病學組,《中華兒科雜志》編輯委員會.川崎病冠狀動脈病變的臨床處理建議(2020年修訂版)[J].中華兒科雜志,2020,58(9):718-724.
[5] McCRINDLE B W,ROWLEY A H,NEWBURGER J W,et al. Diagnosis,treatment,and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association[J].Circulation,2017,135(17): e927-e999.
[6] DALLAIRE F,DAHDAH N. New equations and a critical appraisal of coronary artery Z scores in healthy children[J].J Am Soc Echocardiogr,2011,24(1): 60-74.
[7] YOKOTA S,KIKUCHI M,NOZAWA T,et al. Pathoge-nesis of systemic inflammatory diseases in childhood: "Lessons from clinical trials of anti-cytokine monoclonal antibodies for Kawasaki disease,systemic onset juvenile idiopathic arthritis,and cryopyrin-associated periodic fever syndrome"[J].Modern Rheumatology,2015,25(1): 1-10.
[8] 范雪,徐明國.川崎病發(fā)病機制及治療研究進展[J].中國實用兒科雜志,2021,36(5):339-344.
[9] 黃宏琳,黃育坤,林淑斌,等.TNF-α、IL-1β及IL-6 水平用于評估川崎病患兒發(fā)生冠狀動脈損傷的臨床價值[J].中國醫(yī)學創(chuàng)新,2020,17(4):12-15.
[10] 彭珍,閆孝永.ACEF評分聯(lián)合炎性因子評估小兒川崎病冠狀動脈損害的臨床價值[J].中西醫(yī)結合心腦血管病雜志,2022,20(16):3016-3020.
[11] KIM M K,SONG M S,KIM G B. Factors predicting re-sistance to intravenous immunoglobulin treatment and coronary artery lesion in patients with Kawasaki disease:analysis of the Korean nationwide multicenter survey from 2012 to 2014[J].Korean Circ J,2018,48(1):71-79.
[12] RIFE E,GEDALIA A. Kawasaki disease: An update[J].Curr Rheumatol Rep,2020,22(10):75.
[13] SAMADLI S,LIU F F,MAMMADOV G,et al. The time option of IVIG treatment is associated with therapeutic responsiveness and coronary artery abnormalities but not with clinical classification in the acute episode of Kawasaki disease[J].Pediatr Rheumatol Online J,2019,17(1):53.
[14] 王遠飛,李培嶺,田運嬌,等.川崎病合并中小型冠狀動脈瘤持續(xù)時間危險因素分析[J].中華實用兒科臨床雜志,2022,37(11): 816-820.
[15] 戈海延,曲東,劉霜,等. 6月齡以下嬰兒川崎病冠狀動脈病變的臨床特征及預后分析[J].中國小兒急救醫(yī)學,2022,29(3):206-210.

更新日期/Last Update: 2024-08-15