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[1]余煒,黃靜,余輝,等.基于介孔二氧化硅和聚多巴胺納米載體遞送阿帕替尼的性質研究[J].福建醫(yī)藥雜志,2024,46(02):114-118.[doi:10.20148/j.fmj.2024.02.031]
　YU Wei,HUANG Jing,YU Hui,et al.Study on the properties of apatinib delivery based on mesoporous silica and polydopamine nanocarriers[J].FUJIAN MEDICAL JOURNAL,2024,46(02):114-118.[doi:10.20148/j.fmj.2024.02.031]
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基于介孔二氧化硅和聚多巴胺納米載體遞送阿帕替尼的性質研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年02期
頁碼:
114-118
欄目:
基礎研究
出版日期:
2024-04-15

文章信息/Info

Title:
Study on the properties of apatinib delivery based on mesoporous silica and polydopamine nanocarriers
文章編號:
1002-2600(2024)02-0114-05
作者:
余煒1; 黃靜1; 余輝1; 魏丞2; 范芳1; 林海燕1; 林劍揚1; 翁金森3
1 福建醫(yī)科大學腫瘤臨床醫(yī)學院 福建省腫瘤醫(yī)院臨床藥學室,福州 350014; 2 胃腸外科,福州 350014; 3 重癥醫(yī)學科,福州 350014
Author(s):
YU Wei1; HUANG Jing1; YU Hui1; WEI Cheng2; FAN Fang1; LIN Haiyan1; LIN Jianyang1; WENG Jinsen3
1 Department of Clinical Pharmacy, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fuzhou, Fujian 350122, China; 2 Department of Gastrointestinal Surgery, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fuzhou, Fujian 350122, China; 3 Department of Critical Care Medicine, Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fuzhou, Fujian 350122, China
關鍵詞:
抗腫瘤;  阿帕替尼;  MSNs@PDA-Apa;  納米粒子
Keywords:
antitumor;  apatinib;  MSNs@PDA-Apa;  nanoparticle
分類號:
R943
DOI:
10.20148/j.fmj.2024.02.031
文獻標志碼:
B
摘要:
目的 探討基于介孔二氧化硅和聚多巴胺的納米載體遞送阿帕替尼的效能。方法 利用介孔二氧化硅(MSN)的高效藥物遞送能力和聚多巴胺(PDA)的pH響應性,采用改進的Stober法制備了介孔二氧化硅納米粒子,根據(jù)靜電復合法設計了一種pH響應性聚多巴胺(PDA)包覆的介孔二氧化硅納米給藥系統(tǒng)(MSNs@PDA)。采用掃描電子顯微鏡(SEM)和Zeta電位改變驗證MSNs@PDA系統(tǒng)制備是否成功。測定MSNs@PDA-Apa的載藥量和包埋率。CCK-8法評價體外細胞毒性。Transwell法評價細胞遷移。結果 掃描電子顯微鏡(SEM)和Zeta電位改變驗證MSNs@PDA-Apa制備成功。MSNs@PDA-Apa的藥物載藥量為2.4%,包埋率為48%±2.5%。MSNs@PDA-Apa組的細胞毒性呈濃度依賴性,當濃度達到10 μg/mL時,PC-9細胞的存活率僅為30%左右。與Apa組相比,MSNs@PDA-Apa組對細胞遷移的效果明顯增強。結論 MSNs@PDA-Apa具有較高的藥物傳遞效率,表現(xiàn)出對腫瘤細胞的良好殺傷作用,有望為未來的藥物傳遞系統(tǒng)的構筑提供思路和方法。
Abstract:
Objective To explore the efficacy of nanocarriers based on mesoporous silica and polydopamine for delivering apatinib.Methods By utilizing the efficient drug delivery ability of mesoporous silica(MSN)and the pH responsiveness of polydopamine(PDA), mesoporous silica nanoparticles were prepared using an improved Stober method.A pH responsive polydopamine(PDA)coated mesoporous silica nanodrug delivery system was designed based on electrostatic composite method(MSNs@PDA).The success of MSNs@PDA system preparation was verified by scanning electron microscopy(SEM)and Zeta potential changes.The drug loading capacity and embedding rate of MSNs@PDA-Apa were determined.Vitro cytotoxicity was evaluated by the CCK-8 method.Transwell method was used to evaluate cell migration.Results MSNs@PDA system preparation was successful, which was verified by scanning electron microscopy(SEM)and Zeta potential changes.The drug loading capacity of MSNs@PDA-Apa was 2.4%, and the embedding rate was 48%±2.5%.The cytotoxicity of MSNs@PDA-Apa group was concentration dependent, and when the concentration reached 10 μg/mL, the survival rate of PC-9 cells was only about 30%.Compared to the Apa group, the effect of MSNs@PDA-Apa group on cell migration was significantly enhanced.Conclusion MSNs@PDA-Apa system preparation has a high drug delivery efficiency and exhibits a good killing effect on tumor cells, which is expected to provide ideas and methods for the construction of future drug delivery systems.

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備注/Memo

備注/Memo:
基金項目:福建省自然科學基金項目(2020J011119)
通信作者:翁金森,Email:[email protected]
更新日期/Last Update: 2024-04-15