80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]林俊生,林慧潔,戴煒,等.CD4+Foxp3+調(diào)節(jié)性T細胞在急性髓系白血病中的變化及其預后意義[J].福建醫(yī)藥雜志,2024,46(02):10-13.[doi:10.20148/j.fmj.2024.02.003]
　LIN Junsheng,LIN Huijie,DAI Wei,et al.Changes of regulatory T Cells in acute myeloid leukemia and its prognostic significance[J].FUJIAN MEDICAL JOURNAL,2024,46(02):10-13.[doi:10.20148/j.fmj.2024.02.003]
點擊復制

CD4+Foxp3+調(diào)節(jié)性T細胞在急性髓系白血病中的變化及其預后意義()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年02期
頁碼:
10-13
欄目:
臨床研究
出版日期:
2024-04-15

文章信息/Info

Title:
Changes of regulatory T Cells in acute myeloid leukemia and its prognostic significance
文章編號:
1002-2600(2024)02-0010-04
作者:
林俊生1; 林慧潔2; 戴煒1; 黃曉宇2; 陳君涵1; 張鑫2; 陳加弟1
1 福建醫(yī)科大學附屬協(xié)和醫(yī)院檢驗科,福州 350001; 2 福建醫(yī)科大學醫(yī)學技術與工程學院醫(yī)學檢驗系,福州 350004
Author(s):
LIN Junsheng1; LIN Huijie2; DAI Wei1; HUANG Xiaoyu2; CHEN Junhan1; ZHANG Xin2; CHEN Jiadi1
1 Department of clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China; 2 Department of Medical Laboratory, School of Medical Technology and Engineering, Fujian University, Fuzhou, Fujian 350004, China
關鍵詞:
急性髓系白血病;  調(diào)節(jié)性T細胞;  流式細胞術;  預后
Keywords:
acute myeloid leukemia;  regulatory T cells;  flow cytometry;  prognosis
分類號:
R551.3
DOI:
10.20148/j.fmj.2024.02.003
文獻標志碼:
B
摘要:
目的 探究CD4+Foxp3+調(diào)節(jié)性T細胞(Tregs)在急性髓系白血病(AML)中的變化,并研究其與AML預后的關系。方法 采用流式細胞術檢測來我院就診的初診AML患者和健康對照組外周血Tregs水平; 根據(jù)細胞核型將AML分為預后較好組、預后中等組和預后較差組,比較各組患者Tregs占CD4+T細胞比例,研究外周血Tregs對AML預后的意義。結果 AML患者外周血CD4+Foxp3+ Tregs占CD4+T細胞比例高于健康對照組(6.171%±0.292% vs. 2.437% ± 0.144%,P<0.000 1); 但是各AML亞型中Tregs占CD4+T細胞比例差異無統(tǒng)計學意義(P>0.05); 預后較差組AML患者外周血Tregs占CD4+T細胞比例高于預后較好組(7.316%±0.592% vs. 5.179%±0.429%,P<0.01)。結論 AML患者外周血CD4+Foxp3+ Tregs占CD4+T細胞比例提高,對AML患者預后評估有一定的意義。
Abstract:
Objective To investigate the changes of CD4+Foxp3+ regulatory T cells(Tregs)in acute myeloid leukemia(AML)and its relationship with the prognosis of AML.Methods Flow cytometry was used to detect the percentages of Tregs among CD4+ T cells in peripheral blood of newly diagnosed AML patients and healthy controls.AML patients were divided into good prognosis group, medium prognosis group and poor prognosis group by cytogentic karyotype.Then, the difference in the percentages of Tregs among CD4+ T cells among each group was analyzed to explore the potential prognostic significance of Tregs in AML.Results The percentages of circulating CD4+Foxp3+ Tregs in AML patients was significantly higher than that of healthy controls(6.171% ± 0.292% vs. 2.437% ± 0.144%, P<0.000 1).There was no significant difference in the percentages of Tregs among CD4+ T cells among different subtypes of AML(P>0.05).We found that the ratio of circulating Tregs in the poor prognosis group was significantly higher than that in the better prognosis group(7.316%±0.592% vs. 5.179%±0.429%).Conclusion The percentages of CD4+Foxp3+Tregs among CD4+ T cells are significantly increased in patients with AML, which has certain significance for prognostic evaluation.

參考文獻/References:

[1] ITZYKSON R,FOURNIER E,BERTHON C,et al.Genetic identification of patients with AML older than 60 achieving long-term survival with intensive chemotherapy[J].Blood,2021,138(7):507-519.
[2] 王寧,金敬一,陳麗華.免疫分子對CD4+ Tregs的調(diào)節(jié)作用[J].免疫學雜志,2018,34(1):73-79.
[3] 郭智,舒榕,王強.CD4+CD25+調(diào)節(jié)性T細胞在造血干細胞移植后誘導免疫耐受的作用[J].生命的化學,2020,40(1):75-79.
[4] BAI Y,HE T,ZHANG L,et al.Prognostic value of FOXP3 regulatory T cells in patients with diffuse large B-cell lymphoma:a systematic review and meta-analysis[J].BMJ Open,2022,12(9):e060659.
[5] QIU Y,KE S,CHEN J,et al.Foxp3+ regulatory T cells and the immune escape in solid tumours[J].Front Immunol,2022,13:982986.
[6] 安田麗,李亮亮,趙麗.骨髓微環(huán)境影響調(diào)節(jié)性T細胞促進血液惡性腫瘤發(fā)展的研究進展[J].中國免疫學雜志,2021,37(5):635-640,
[7] JAUNG J,CHO B S,KIM H J,et al.Reclassification of acute myeloid leukemia according to the 2016 WHO classification[J].Ann Lab Med,2019,39(3):311-316.
[8] HAFERLACH T,SCHNITTGER S,KERM W,et al.Genetic classification of acute myeloid leukemia(AML)[J].Ann Hematol,2004,83(Suppl 1):S97-S100.
[9] ARIK D,BENLI T,TELLI E.Number of Foxp3+ regulatory T-cells are associated with recurrence in vulvar squamous cell carcinoma[J].J Gynecol Oncol,2023,34(2):e16.
[10] 劉洪博,王文智,石慶芳.NK細胞和Tregs細胞亞群在宮頸癌患者外周血中表達及臨床意義[J].中國老年學雜志,2020,4(2):284-287.
[11] NOROUZIAN M,MEHDIPOUR F,ASHRAF M J,et al.Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck[J].BMC Immunol,2022,23(1):56.
[12] 柯星,張良,沈立松.CD4+CD25highCD127low調(diào)節(jié)性T細胞促進上皮性卵巢癌轉(zhuǎn)移機制的初步探討[J].檢驗醫(yī)學,2019,34(2):110-115.
[13] 張勇.腫瘤微環(huán)境中CD4+Foxp3+Tregs對鼻咽癌患者預后影響[J].中國實驗診斷學,2019,23(10):1723-1727.
[14] 陳熙勐,張皓旻,楊波,等.急性髓系白血病患者預后不良相關基因的多組學分析[J].中國實驗血液學雜志,2019,27(2):331-338.
[15] DONG Y,HAN Y,HUANG Y,et al.PD-L1 is expressed and promotes the expansion of regulatory T cells in acute myeloid leukemia[J].Front Immunol,2020,11:1710.
[16] WANG M,ZHANG C,TIAN T,et al.Increased regulatory T cells in peripheral blood of acute myeloid leukemia patients rely on tumor necrosis factor(TNF)-α-TNF receptor-2 pathway[J].Front Immunol,2018,9:1274.
[17] ARANDI N,RAMZI M,SAFAEI F,et al.Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype[J].Blood Res,2018,53(4):294-298.

備注/Memo

備注/Memo:
基金項目:福建省自然科學基金資助項目(2021J05049)
通信作者:陳加弟,Email:[email protected]
更新日期/Last Update: 2024-04-15