80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少?

[1]姚義,張明基.骨髓間充質(zhì)干細(xì)胞對(duì)重癥急性胰腺炎大鼠相關(guān)肺損傷的實(shí)驗(yàn)研究[J].福建醫(yī)藥雜志,2024,46(01):120-124181.[doi:10.20148/j.fmj.2024.01.033]
點(diǎn)擊復(fù)制

骨髓間充質(zhì)干細(xì)胞對(duì)重癥急性胰腺炎大鼠相關(guān)肺損傷的實(shí)驗(yàn)研究()
分享到:

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年01期
頁(yè)碼:
120-124181
欄目:
基礎(chǔ)研究
出版日期:
2024-02-15

文章信息/Info

文章編號(hào):
1002-2600(2024)01-0120-06
作者:
姚義張明基
福建醫(yī)科大學(xué)腫瘤臨床醫(yī)學(xué)院 福建省腫瘤醫(yī)院肝膽胰外科,福州 350014
關(guān)鍵詞:
重癥急性胰腺炎肺損傷骨髓間充質(zhì)干細(xì)胞通透性緊密連接蛋白
分類號(hào):
R657.5
DOI:
10.20148/j.fmj.2024.01.033
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的探討骨髓間充質(zhì)干細(xì)胞(BMMSCs)對(duì)重癥急性胰腺炎(SAP)大鼠肺損傷中ZO-1、Occludin表達(dá)的影響。方法將105只雄性SD大鼠隨機(jī)分成假手術(shù)組(SO組)、SAP組和 BMMSCs干預(yù)組;后兩組再按處死時(shí)間不同分為6 h、12 h和24 h組,觀察各組間肺的病理變化及肺毛細(xì)血管通透性改變情況;通過(guò)Western blot、RT-PCR檢測(cè)各組間ZO-1、Occludin蛋白和mRNA的改變情況。結(jié)果與SO組相比,SAP組各時(shí)間點(diǎn)肺、胰腺的病理改變明顯,肺毛細(xì)血管的通透性明顯增加(P<0.05),肺濕干比值增加(P<0.05),肺ZO-1、Occludin蛋白和mRNA表達(dá)明顯降低(P<0.05);與SAP組比較,BMMSCs干預(yù)組各時(shí)間點(diǎn)肺、胰腺的病理改變減輕,肺毛細(xì)血管通透性改變減輕,肺組織濕干比值降低,肺ZO-1、Occludin蛋白和mRNA表達(dá)升高,12 h和24 h時(shí)間點(diǎn)表現(xiàn)的更為明顯(P<0.05)。結(jié)論 BMMSCs可使肺中ZO-1、Occludin的表達(dá)增加,這可能在減輕SAP相關(guān)肺損傷和改善肺毛細(xì)血管通透性方面發(fā)揮重要作用。

參考文獻(xiàn)/References:

[1] YANG Q,LUO Y,LAN B,et al.Fighting fire with fire: exosomes and acute pancreatitis-associated acute lung injury [J].Bioengineering(Basel),2022,9(11):615.
[2] KHORASANI H R,SANCHOULI M,MEHRANI J,et al.Potential of bone-marrow-derived mesenchymal stem cells for maxillofacial and periodontal regeneration: a narrative review[J].Int J Dent,2021,2021(1):1-13.
[3] WANG Z,YU T,HOU Y P,et al.Mesenchymal stem cell therapy for ALI/ARDS: therapeutic potential and challenges [J].Current Pharmaceutical Design,2022,28(27):2234-2240.
[4] NIU H,SONG H,GUAN Y H,et al.Chicken bone marrow mesenchymal stem cells improve lung and distal organ injury[J].Sci Rep,2021,11(1): 1-17.
[5] LI Q,CHEN X,LI J.Marrow-derived mesenchymal stem cells regulate the inflammatory response and repair alveolar type Ⅱ epithelial cells in acute lung injury of rats[J].J Int Med Res,2020,48(4):1-14.
[6] ZHAO D,YU W,XIE W,et al.Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats [J].Mol Cell Biochem,2022,477(12):2761-2771.
[7] GE P,LUO Y,OKOYE C S,et al.Intestinal barrier damage,systemic inflammatory response syndrome,and acute lung injury: a troublesome trio for acute pancreatitis [J].Biomed Pharmacother,2020,132(2020):110770.
[8] LI J,QI Z,LI D,et al.Alveolar epithelial glycocalyx shedding aggravates the epithelial barrier and disrupts epithelial tight junctions in acute respiratory distress syndrome[J].Biomed Pharmacother,2021,133(2021):111026.
[9] KIM Y H,KIM K J,D'Argenio D Z,et al.Characteristics of passive solute transport across primary rat alveolar epithelial cell monolayers [J].Membranes(Basel),2021,11(5):331.
[10] DONG H,WANG Z,CHEN Y,et al.Protective effects of bone marrow-derived mesenchymal stem cells on insulin secretion and inflammation in the treatment of severe acute pancreatitis in rats [J].Transplant Proc,2020,52(1):333-344.
[11] ZHAO D,YU W,XIE W,et al.Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats[J].Mol Cell Biochem,2022,477(12):2761-2771.
[12] BARRY M,TRIVEDI A,PATHIPATI P,et al.Mesen-chymal stem cell extracellular vesicles mitigate vascular permeability and injury in the small intestine and lung in a mouse model of hemorrhagic shock and trauma [J].J Trauma Acute Care Surg,2022,92(3):489-498.
[13] QU Y,ZHANG L,HE D,et al.Protective role of mesenchymal stem cells transfected with miRNA-378a-5p in phosgene inhalation lung injury [J].Biochem Biophys Res Commun,2020,530(1):189-195.

備注/Memo

備注/Memo:
通信作者:張明基,Email:[email protected]
更新日期/Last Update: 2024-02-15