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[1]陳冬冬,鄭竑.BPQDs@TNTs藥物載體的構(gòu)建及其緩釋性能研究[J].福建醫(yī)藥雜志,2024,46(01):21-24.[doi:10.20148/j.fmj.2024.01.006]
　CHEN Dongdong,ZHENG Hong.Construction of BPQDS@TNTS drug carrier and its sustained release properties[J].FUJIAN MEDICAL JOURNAL,2024,46(01):21-24.[doi:10.20148/j.fmj.2024.01.006]
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BPQDs@TNTs藥物載體的構(gòu)建及其緩釋性能研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
46
期數(shù):
2024年01期
頁(yè)碼:
21-24
欄目:
臨床研究
出版日期:
2024-02-15

文章信息/Info

Title:
Construction of BPQDS@TNTS drug carrier and its sustained release properties
文章編號(hào):
1002-2600（2024）01-0021-04
作者:
陳冬冬; 鄭竑
福建省福州市第二醫(yī)院骨科，福州 300007
Author(s):
CHEN Dongdong;  ZHENG Hong
Department of Orthopaedics, Fuzhou Second Hospital, Fuzhou, Fujian 350007, China
關(guān)鍵詞:
TiO2納米管陣列; 黑磷量子點(diǎn); 阿侖磷酸鈉; 硫酸慶大霉素
Keywords:
TiO2 nanotube array;  black phosphorus quantum dots;  alendronate sodium phosphate;  sulfuric gentamicin
分類號(hào):
R68
DOI:
10.20148/j.fmj.2024.01.006
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的在骨科鈦板表面構(gòu)建能負(fù)載阿侖膦酸鈉及硫酸慶大霉素的雙載藥復(fù)合藥物載體。方法通過(guò)陽(yáng)極氧化法在TiO2表面制備納米管陣列（TNTs），動(dòng)態(tài)吸附阿倫磷酸鈉后再填充載有硫酸慶大霉素的載藥黑磷量子點(diǎn)（BPQDs），管口采用肉豆蔻醇進(jìn)行封裝，并利用X射線衍射、透射電鏡進(jìn)行表征，最后通過(guò)液相色譜法測(cè)定其上負(fù)載的阿侖膦酸鈉及硫酸慶大霉素的緩釋速率。結(jié)果X射線衍射表明構(gòu)建的BPQDs@TNTs藥物載體具備BP和TNTs的特征衍射峰，透射電鏡掃描表明，肉豆蔻醇成功地對(duì)TNTs進(jìn)行了封口，TiO2納米管中的阿侖膦酸鈉及BPQDs載體的硫酸慶大霉素在72 h內(nèi)已基本釋放完畢，BPQDs@TNTs藥物載體上阿侖膦酸鈉及硫酸慶大霉素則在96 h內(nèi)才基本釋放完畢。結(jié)論BPQDs@TNTs藥物載體能成功搭載阿侖膦酸鈉及硫酸慶大霉素，且在體液中具有更好的緩釋效能。
Abstract:
ObjectiveTo construct a dual-drug-loaded composite drug carrier loaded with alendronate and gentamicin on orthopaedic titanium plate. MethodsNanotube arrays(TNTs) were prepared on the surface of TiO2 by anodic oxidation, then dynamically adsorbed sodium alendronate and were filled with gentamicin sulfate-loaded BP quantum dots(BPQDs).The tube mouth was encapsulated with nutmeg. The tube was characterized by X-ray diffraction and transmission electron microscopy.The sustained release rate of alendronate and gentamicin loaded on the tube was determined by chromatography. ResultsX-ray diffraction showed that the BPQDS@TNTS drug carrier had characteristic diffraction peaks of BP and TNTs. Transmission electron microscopy showed that nutmeg had successfully sealed TNTs, the alendronate and sulphate gentamicin in TiO2 nanotubes and BPQDs carriers were almost completely released within 72 hours, while the alendronate and sulphate gentamicin in BPQDs@TNTs carriers were almost completely released within 96 hours.ConclusionBPQDs@TNTs drug carrier can successfully carry alendronate and gentamicin sulfate, and has better sustained-release efficacy in body fluids.

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備注/Memo

備注/Memo:
基金項(xiàng)目：2021年福州市科技計(jì)劃項(xiàng)目（2021-S-159）；2020年福建省衛(wèi)健委醫(yī)學(xué)創(chuàng)新課題B類（2020CXB037）
通信作者：鄭竑，Email：[email protected]
更新日期/Last Update: 2024-02-15