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[1]李業(yè)森.特異性靶向高轉(zhuǎn)移骨肉瘤的長(zhǎng)循環(huán)型PET探針的合成及顯像[J].福建醫(yī)藥雜志,2023,45(06):127-129.
　LI Yesen.Synthesis and imaging of long-circulating PET probes specifically targeting highly metastatic osteosarcoma[J].FUJIAN MEDICAL JOURNAL,2023,45(06):127-129.
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特異性靶向高轉(zhuǎn)移骨肉瘤的長(zhǎng)循環(huán)型PET探針的合成及顯像()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年06期
頁碼:
127-129
欄目:
基礎(chǔ)研究
出版日期:
2023-12-15

文章信息/Info

Title:
Synthesis and imaging of long-circulating PET probes specifically targeting highly metastatic osteosarcoma
文章編號(hào):
1002-2600(2023)06-0127-03
作者:
李業(yè)森
廈門大學(xué)附屬第一醫(yī)院核醫(yī)學(xué)科(廈門 361003)
Author(s):
LI Yesen
Department of Nuclear Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, China
關(guān)鍵詞:
PET;  骨肉瘤;  [64Cu]Cu-DOTA-EB-TMTP1;  64Cu標(biāo)記
Keywords:
PET;  osteosarcoma;  [64Cu]Cu-DOTA-EB-TMTP1;  64Cu labelling
分類號(hào):
R814
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 研究[64Cu]Cu-DOTA-EB-TMTP1對(duì)143B骨肉瘤荷瘤小鼠模型的診斷效果。方法 多肽TMTP1(NVVRQ)對(duì)高轉(zhuǎn)移性細(xì)胞有很好的靶向性,本研究利用64Cu標(biāo)記DOTA-EB-TMTP1合成[64Cu]Cu-DOTA-EB-TMTP1,然后對(duì)143B骨肉瘤肝癌荷瘤小鼠進(jìn)行microPET/CT顯像,研究其對(duì)腫瘤的診斷效果。結(jié)果 [64Cu]Cu-DOTA-EB-TMTP1的放射性標(biāo)記產(chǎn)率為(87.3±5.2)%,放化純度大于95.0%。實(shí)驗(yàn)證明經(jīng)過伊文思藍(lán)(Evans Blue)修飾后的TMTP1,具有更高的腫瘤攝取和更長(zhǎng)的血液半衰期,8 h腫瘤攝取值可達(dá)(6.50±0.88)% ID/g。結(jié)論 對(duì)于骨肉瘤的診斷來說,[64Cu]Cu-DOTA-EB-TMTP1可能是更好的PET探針,更有利于腫瘤的診療一體化轉(zhuǎn)化應(yīng)用。
Abstract:
Objective To assess the diagnostic effectiveness of [64Cu]Cu-DOTA-EB-TMTP1 in a mouse model of 143B osteosarcoma.Methods Polypeptide TMTP1(NVVRQ)had good targeting effect on highly metastatic cells.[64Cu]Cu-DOTA-EB-TMTP1 was synthesized and subsequently used for microPET/CT imaging in a mouse model of 143B osteosarcoma to investigate its diagnostic performance.Results The radiolabeling yield of [64Cu]Cu-DOTA-EB-TMTP1 was(87.3±5.2)%, and the radiochemical purity exceeded 95.0%.The results demonstrated that TMTP1, modified with Evans Blue, exhibited increased tumor uptake and a longer blood half-life.Tumor uptake values reached(6.50±0.88)% ID/g at eight hours.Conclusion [64Cu]Cu-DOTA-EB-TMTP1 may represent a superior PET probe for the diagnosis of osteosarcoma, facilitating the integration of diagnosis and therapy for this condition.

參考文獻(xiàn)/References:

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更新日期/Last Update: 2023-12-15