80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]江若紅,陳云麗,張亞敏,等.基于網(wǎng)絡(luò)藥理學(xué)探討澤瀉飲治療“酒風(fēng)”的作用機(jī)制[J].福建醫(yī)藥雜志,2023,45(06):119-123.
　JIANG Ruohong,CHEN Yunli,ZHANG Yamin,et al.Mechanism of Zexieyin in the treatment of “Jiufeng” based on network pharmacology[J].FUJIAN MEDICAL JOURNAL,2023,45(06):119-123.
點(diǎn)擊復(fù)制

基于網(wǎng)絡(luò)藥理學(xué)探討澤瀉飲治療“酒風(fēng)”的作用機(jī)制()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年06期
頁碼:
119-123
欄目:
基礎(chǔ)研究
出版日期:
2023-12-15

文章信息/Info

Title:
Mechanism of Zexieyin in the treatment of “Jiufeng” based on network pharmacology
文章編號(hào):
1002-2600(2023)06-0119-05
作者:
江若紅; 陳云麗; 張亞敏1; 林文津1; 2
福建中醫(yī)藥大學(xué)(福州 350001)
Author(s):
JIANG Ruohong;  CHEN Yunli;  ZHANG Yamin;  LIN Wenjin
Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
澤瀉飲;  網(wǎng)絡(luò)藥理學(xué);  “酒風(fēng)”;  分子對(duì)接;  作用機(jī)制
Keywords:
Zexieyin;  network pharmacology;  Jiufeng;  molecular docking;  mechanism
分類號(hào):
R963
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 通過網(wǎng)絡(luò)藥理學(xué)探討澤瀉飲治療“酒風(fēng)”的作用機(jī)制。方法 利用多個(gè)數(shù)據(jù)庫收集澤瀉飲治療“酒風(fēng)”的活性成分和交集靶點(diǎn),隨后構(gòu)建蛋白互作網(wǎng)絡(luò)圖、藥物-活性成分-交集靶點(diǎn)網(wǎng)絡(luò)圖,并進(jìn)行富集分析和分子對(duì)接驗(yàn)證。結(jié)果 篩選出6個(gè)核心活性成分,分別為山柰酚、槲皮素、澤瀉醇A、23-乙酰澤瀉醇B、澤瀉醇C 、白術(shù)內(nèi)酯I,IL-1β、TNF、AKT1、MAPK3等8個(gè)關(guān)鍵靶點(diǎn)。通過Metascape數(shù)據(jù)庫分析后得到450條GO 生物過程及 192條KEGG 相關(guān)信號(hào)通路,主要涉及癌癥通路、TRP 通道的炎癥介質(zhì)調(diào)節(jié)、AMPK信號(hào)通路等。核心活性成分與關(guān)鍵靶點(diǎn)的結(jié)合能力較好。結(jié)論 通過網(wǎng)絡(luò)藥理學(xué)和分子對(duì)接驗(yàn)證,發(fā)現(xiàn)其可以通過山柰酚、槲皮素、澤瀉醇A、23-乙酰澤瀉醇B、澤瀉醇C、白術(shù)內(nèi)酯I等成分作用于IL-1β、TNF、AKT1、MAPK3等靶點(diǎn)發(fā)揮抗炎、免疫、調(diào)控細(xì)胞增殖凋亡等作用,為今后進(jìn)一步研究“酒風(fēng)”提供依據(jù)。
Abstract:
Objective To explore the mechanism of action of Zexieyin in the treatment of “Jiufeng” through network pharmacology.Methods Using multiple databases to collect the active ingredients and intersection targets of Zexieyin in the treatment of “Jiufeng”, then constructing protein interaction network diagrams and drug active ingredient intersection target network diagrams, and conducting enrichment analysis and molecular docking verification.Results Six core active ingredients were selected, including kaempferol, quercetin, alisol A, 23-acetylalisol B, alisol C, atractylolide I, and eight key targets including IL-1 β、 TNF, AKT1, MAPK3.After analyzing the Metascape database, 450 GO biological processes and 192 KEGG related signaling pathways were identified, mainly involving cancer pathways, inflammatory mediator regulation of TRP channels, and AMPK signaling pathways.The binding ability of the core active ingredients to key targets is good.Conclusion Through the network pharmacology and molecular docking verification, it is found that it can act on targets such as IL-1β, TNF, AKT1, and MAPK3 through kaempferol, quercetin, alisol A, 23-acetyl alisol B, alisol C, atractylide I and other components,and play a role in anti-inflammation, immunity, regulation of cell proliferation and apoptosis, and providing a basis for further research on “Jiufeng” in the future.

參考文獻(xiàn)/References:

[1] 錢會(huì)南.《黃帝內(nèi)經(jīng)》十三方的后世臨床運(yùn)用啟示[J].安徽中醫(yī)藥大學(xué)學(xué)報(bào), 2023, 42(3):1-4.
[2] Fang S, Dong L, Liu L, et al.HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine[J].Nucleic Acids Res, 2021, 49(D1):D1197-D1206.
[3] Gfeller D, Grosdidier A, Wirth M, et al.Swiss target prediction: a web server for target prediction of bioactive small molecules[J].Nucleic Acids Res, 2014, 42(Web Server issue):W32-38.
[4] Franceschini A, Szklarczyk D, Frankild S, et al.STRING v9.1: protein-protein interaction networks, with increased coverage and integration[J].Nucleic Acids Res, 2013, 41(Database issue):D808-815.
[5] Zhou Y, Zhou B, Pache L, et al.Metascape provides a biologist-oriented resource for the analysis of systems-level datasets[J].Nat Commun, 2019, 10(1):1523.
[6] Zhang D Y, Yao X H, Duan M H, et al.An effective homogenate-assisted negative pressure cavitation extraction for the determination of phenolic compounds in pyrola by LC-MS/MS and the evaluation of its antioxidant activity[J].Food Funct, 2015, 6(10):3323-3333.
[7] 高改, 李二穩(wěn), 王夢(mèng)瑤, 等.基于SREBPs的澤瀉活性成分及其降脂作用研究[J].時(shí)珍國醫(yī)國藥, 2022, 33(3):521-526.
[8] 顏培正, 孟慶巖, 常興, 等.《黃帝內(nèi)經(jīng)》“酒風(fēng)”病因病機(jī)探析[J].中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志, 2017, 23(2):149-150,155.
[9] 謝治深, 黃小虹, 袁永, 等.澤瀉抑制脂多糖誘導(dǎo)的RAW264.7炎癥及作用機(jī)制[J].時(shí)珍國醫(yī)國藥, 2020, 31(7):1586-1590.
[10] 陳琴華, 余飛, 王紅梅, 等.白術(shù)內(nèi)酯Ⅰ、Ⅱ、Ⅲ對(duì)炎性巨噬細(xì)胞細(xì)胞因子表達(dá)的影響[J].中國藥師, 2017, 20(12):2112-2116.
[11] Chen Y, Yang W, Guo L, et al.Atractylodes lactone compounds inhibit platelet activation[J].Platelets, 2017, 28(2):194-202.
[12] 郭雨雅, 孫曉琦, 方晶, 等.加味澤瀉湯對(duì)NAFLD大鼠肝臟炎癥信號(hào)通路相關(guān)蛋白表達(dá)的影響[J].中國實(shí)驗(yàn)方劑學(xué)雜志, 2017, 23(5):90-94.
[13] Matsushita T, Sasaki H, Takayama K, et al.The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes[J].J Orthop Res, 2013, 31(4):531-537.

相似文獻(xiàn)/References:

[1]吳鎧悅,張麗允,馮文敏,等.基于網(wǎng)絡(luò)藥理學(xué)探討西黃丸治療肝癌的作用機(jī)制[J].福建醫(yī)藥雜志,2024,46(02):118.[doi:10.20148/j.fmj.2024.02.032]

備注/Memo

備注/Memo:
基金項(xiàng)目:福建省屬公益科研院所基本專項(xiàng)( 2021R1012001); 福建省醫(yī)學(xué)創(chuàng)新課題(2021CXA038)
1 福建省醫(yī)學(xué)科學(xué)研究院 福建省醫(yī)學(xué)測(cè)試重點(diǎn)實(shí)驗(yàn)室; 2 通信作者,Email:[email protected]
更新日期/Last Update: 2023-12-15