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[1]劉崇武,吳春芳,陳鈺玲,等.慢性牙周炎患者牙周基礎(chǔ)治療前后齦溝液中DEL-1水平的變化[J].福建醫(yī)藥雜志,2023,45(06):12-16.
 LIU Chongwu,WU Chunfang,CHEN Yuling,et al.Changes of DEL-1 levels in gingival crevicular fluid before and after initial therapy of chronic periodontitis[J].FUJIAN MEDICAL JOURNAL,2023,45(06):12-16.
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慢性牙周炎患者牙周基礎(chǔ)治療前后齦溝液中DEL-1水平的變化()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年06期
頁碼:
12-16
欄目:
臨床研究
出版日期:
2023-12-15

文章信息/Info

Title:
Changes of DEL-1 levels in gingival crevicular fluid before and after initial therapy of chronic periodontitis
文章編號:
1002-2600(2023)06-0012-05
作者:
劉崇武吳春芳陳鈺玲鐘泉黃江濤1伍曉紅2
福建醫(yī)科大學(xué)附屬口腔醫(yī)院(福州 350002)
Author(s):
LIU Chongwu WU Chunfang CHEN Yuling ZHONG Quan HUANG Jiangtao WU Xiaohong
School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian 350002, China
關(guān)鍵詞:
發(fā)育性內(nèi)皮細胞基因-1 慢性牙周炎 牙周基礎(chǔ)治療 齦溝液
Keywords:
developmental endothelial locus-1 chronic periodontitis initial periodontal therapy gingival crevicular fluid
分類號:
R781.4
文獻標(biāo)志碼:
B
摘要:
目的 分析牙周基礎(chǔ)治療前后慢性牙周炎患者齦溝液(gingival crevicular fluid,GCF)中發(fā)育性內(nèi)皮細胞基因-1(developmental endothelial locus-1,DEL-1)水平的變化,探究DEL-1與慢性牙周炎之間的相關(guān)性。方法 納入中重度慢性牙周炎患者20名,于牙周基礎(chǔ)治療前及治療后6周進行牙周臨床檢查,同時檢測患者GCF中DEL-1的水平。比較患者治療前后的探診深度(probing depth,PD)、附著喪失(attachment loss,AL)、出血指數(shù)(bleeding index,BI)以及GCF中DEL-1的水平。結(jié)果 慢性牙周炎患者經(jīng)過完善的牙周基礎(chǔ)治療,牙周臨床指標(biāo)PD、AL、BI均較治療前顯著降低,GCF中DEL-1水平較治療前顯著增加(P<0.001)。結(jié)論 牙周基礎(chǔ)治療后慢性牙周炎患者GCF的DEL-1水平可顯著提高,GCF中DEL-1的水平有望成為評估牙周基礎(chǔ)治療療效的客觀指標(biāo)。
Abstract:
Objective To observe the changes in developmental endothelial locus-1(DEL-1)levels in gingival crevicular fluid(GCF)before and after initial therapy in patients diagnosed with chronic periodontitis, and further investigate the relationship between DEL-1 and chronic periodontitis.Methods Twenty patients diagnosed with moderate to severe chronic periodontitis were included in this study.Clinical periodontal examinations were performed both before the initial therapy and six weeks after treatment.GCF samples were collected, and the expression of DEL-1 was quantified by using an enzyme-linked immunosorbent assay(ELISA).Changes in probing depth(PD), attachment loss(AL), bleeding index(BI), and DEL-1 levels in GCF were compared before and after initial therapy.Results Following comprehensive initial therapy for chronic periodontitis, there was a significant reduction in clinical periodontal indicators, including PD, AL, and BI when compared with baseline va-lues.Furthermore, DEL-1 levels in GCF exhibited a substantial increase compared with the pre-treatment levels(P<0.001).Conclusion After initial therapy, the levels of DEL-1 in the GCF of chronic periodontitis patients significantly increase.The DEL-1 levels in GCF hold promise as an objective marker for evaluating the effectiveness of initial therapy.

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備注/Memo

備注/Memo:
基金項目:福建省衛(wèi)生健康科技計劃項目資助(2022CXB013); 福建省自然科學(xué)基金項目(2022J01765)
1 福建醫(yī)科大學(xué)口腔醫(yī)學(xué)院; 2 通信作者,Email:[email protected]
更新日期/Last Update: 2023-12-15