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[1]曾艷芬,曹鵬駒,竇敏.纖維蛋白（原）降解產(chǎn)物/D-二聚體比值的臨床應(yīng)用探討[J].福建醫(yī)藥雜志,2023,45(04):16-19.
　ZENG Yanfen,CAO Pengju,DOU Min.Exploration of the clinical application of FDP/DD ratio[J].FUJIAN MEDICAL JOURNAL,2023,45(04):16-19.
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纖維蛋白（原）降解產(chǎn)物/D-二聚體比值的臨床應(yīng)用探討()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年04期
頁碼:
16-19
欄目:
臨床研究
出版日期:
2023-08-15

文章信息/Info

Title:
Exploration of the clinical application of FDP/DD ratio
文章編號:
1002-2600(2023)04-0016-04
作者:
曾艷芬; 曹鵬駒1; 竇敏1; 2
福建省立醫(yī)院 福建省臨床檢驗中心(福州 350001)
Author(s):
ZENG Yanfen;  CAO Pengju;  DOU Min
Fujian Provincial Center for Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
D-二聚體;  FDP;  FDP/DD比值;  臨床應(yīng)用
Keywords:
D-dimer;  FDP;  FDP/DD ratio;  clinical application
分類號:
R34
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討纖維蛋白(原)降解產(chǎn)物(FDP)/纖維蛋白降解產(chǎn)物D-二聚體(DD)比值在不同檢測系統(tǒng)的差異、對DIC高凝期的鑒別效能及對DD檢測結(jié)果的干擾識別能力。方法 非DIC患者90例,同時在CS5100和STA-R-Evolution檢測DD、FDP,計算FDP/DD比值; 回顧分析20例DIC高凝期、20例DIC纖溶期,計算FDP/DD比值; 另收集FDP/DD比值<1.7和FDP/DD比值2～3的標(biāo)本各10例,分別檢測原倍和1:8稀釋的DD結(jié)果,計算稀釋前后FDP/DD比值。結(jié)果 90例非DIC患者兩臺儀器DD在中值組和高值組差異有統(tǒng)計學(xué)意義(P<0.05), FDP3組差異無統(tǒng)計學(xué)意義(P>0.05); FDP/DD3組差異均有統(tǒng)計學(xué)意義(P<0.05)。DIC高凝期組與非DIC組比較,差異有統(tǒng)計學(xué)意義(P<0.01); DIC高凝期組與纖溶組比較差異有統(tǒng)計學(xué)意義(P<0.01)。正常組1:8稀釋后中的DD、FDP/DD比值與原倍差異無統(tǒng)計學(xué)意義(P>0.05); 干擾組1:8稀釋后DD、FDP/DD比值與原倍比較,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 FDP/DD比值在兩種檢測系統(tǒng)的差異有統(tǒng)計學(xué)意義; 能為臨床DIC早期高凝階段的診斷提供幫助; 能有效識別DD檢測干擾。
Abstract:
Objective To explore the difference of FDP/DD ratio in different detection systems, the discriminating efficiency of highcoagulation stage of DIC and the ability of interference identification of DD detection results. Methods A total of 90 inpatients with non-DIC were collected, at the same time, DD and FDP were detected by CS5100 and STA-R-E-vdution, and the FDP/DD ratio was calculated. According to the test results of TAT, PIC, Fib, Plt and thromboelastography, 20 cases of DIC hypercoagulable phase and 20 cases of DIC fibrinolytic phase were selected to calculate the FDP/DD ratio. In addition, 10 cases with FDP/DD ratio <1.7 and 10 inpatients with FDP/DD ratio 2-3 were collected. The DD results of primary dilution and 1:8 dilution were detected respectively, and the FDP/DD ratio before and after dilution was calculated. Results In 90 non-DIC patients, there was a significant difference in DD between the median group and the high group(P<0.05), but there was no significant difference in FDP among the three groups(P>0.05). There were significant differences in FDP/DD among the three groups(P<0.05). There was significant difference between DIC hypercoagulable group and non-DIC group(P<0.01). There was significant difference between the DIC high coagulation stage group and fibrinolysis group(P<0.01). There was no significant difference in DD and FDP/DD ratio between 1:8 dilution and original fold in normal group(P>0.05). There were significant differences in DD and FDP/DD ratio between the interference group and the original ratio after 1:8 dilution(P<0.05). Conclusion FDP/DD ratio is significantly different between the two detection systems, which can provide meaningful help for the diagnosis of early hypercoagulablestage of DIC and effectively identify the interference of DD detection.

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備注/Memo

備注/Memo:
1 福建省立醫(yī)院檢驗科; 2 通信作者,Email: [email protected]
更新日期/Last Update: 2023-08-15