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[1]鄭圣斌,楊國華.結(jié)直腸癌患者癌組織中成纖維細(xì)胞生長因子19的表達(dá)及其意義[J].福建醫(yī)藥雜志,2023,45(04):1-4.
　ZHENG Shengbin,YANG Guohua.Expression and significance of FGF19 in colorectal cancer tissue[J].FUJIAN MEDICAL JOURNAL,2023,45(04):1-4.
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結(jié)直腸癌患者癌組織中成纖維細(xì)胞生長因子19的表達(dá)及其意義()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年04期
頁碼:
1-4
欄目:
臨床研究
出版日期:
2023-08-15

文章信息/Info

Title:
Expression and significance of FGF19 in colorectal cancer tissue
文章編號:
1002-2600(2023)04-0001-04
作者:
鄭圣斌; 楊國華1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院南院普外科(福州 350007)
Author(s):
ZHENG Shengbin;  YANG Guohua
Department of General Surgery,Fujian Provincial Hospital south branch,Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350007, China
關(guān)鍵詞:
FGF19;  結(jié)直腸癌;  脈管癌栓;  神經(jīng)侵犯;  侵襲與轉(zhuǎn)移
Keywords:
FGF19;  colorectal cancer;  invasion and metastasis
分類號:
R735.34
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 探討成纖維細(xì)胞生長因子19(FGF19)在結(jié)直腸癌中的表達(dá)及其預(yù)測結(jié)直腸癌神經(jīng)侵犯及脈管癌栓可行性。方法 選取我院2015—2016年結(jié)直腸癌手術(shù)后標(biāo)本60例,取癌組織及癌旁組織,應(yīng)用免疫組化分析兩者FGF19蛋白的表達(dá)情況,并分析FGF19表達(dá)與病理參數(shù)之間的關(guān)系; 應(yīng)用ROC曲線觀察FGF19預(yù)測結(jié)直腸癌神經(jīng)轉(zhuǎn)移及脈管癌栓情況; 應(yīng)用GEPIA公共數(shù)據(jù)庫生物信息學(xué)平臺分析FGF19表達(dá)與結(jié)直腸癌患者生存期及無疾病生存期曲線。結(jié)果 FGF19在結(jié)直腸癌組織表達(dá)明顯高于癌旁組織; FGF19高表達(dá)組脈管癌栓、神經(jīng)侵犯明顯高于低表達(dá)組,差異有統(tǒng)計學(xué)意義(P<0.01); FGF19高表達(dá)組年齡明顯低于低表達(dá)組,差異有統(tǒng)計學(xué)意義(P<0.01); ROC曲線提示FGF19>65時,預(yù)測神經(jīng)侵犯及脈管癌栓敏感性及特異性均較高。結(jié)論 FGF19表達(dá)與結(jié)直腸癌的脈管癌栓及神經(jīng)侵犯關(guān)系密切,可作為脈管癌栓及神經(jīng)侵犯的預(yù)測因子。
Abstract:
Objective To investigate the expression of fibroblast growth factor 19(FGF19) in colorectal cancer and whether there is a correlation between it and the clinicopathological parameters of colorectal cancer. Methods Sixty postoperative colorectal cancer specimens were selected from our hospital between 2015 and 2016, and cancerous and paracancerous tissues were taken, and the expression of FGF19 protein in both was analyzed by immunohistochemistry; and the relationship between FGF19 protein and pathological parameters was analyzed; ROC curves were used to observe neural metastasis and vascular cancer embolism by FGF19 in colorectal cancer; The GEPIA public database bioinformatics platform was adopted to analyze the expression of FGF19 and its association with overall survival and disease-free survival curves in patients with colorectal cancer. Results FGF19 was significantly higher in colorectal cancer tissues than in paracancerous tissues; vascular cancer thrombosis and nerve invasion were significantly higher in the FGF19 high expression group than that in the low expression group(P<0.01); the age of the FGF19 high expression group was significantly lower than that of the low expression group(P<0.01); the sensitivity and specificity of the ROC curve suggested that the prediction of nerve invasion and vascular thrombosis was higher when FGF19 was >65. Conclusion FGF19 protein is positively correlated with vascular cancer thrombosis and nerve invasion in colorectal cancer, and can be used as a predictor of them.

參考文獻(xiàn)/References:

[1] 陳萬青,張思維,曾紅梅,等.中國2010年惡性腫瘤發(fā)病與死亡[J].中國腫瘤,2014,23(1):1-10.
[2] Betge J,Pollheimer M J,Lindtner R A,et al.Intramural and extramural vascular invasion in colorectal cancer:prognostic significance and quality of pathology reporting[J].Cancer,2012,118(3):628-638.
[3] Zhang X L,Wang Z H,Tian L,et al.Increased expression of FGF19 contributes to tumor progression and cell motility of human thyroid cancer[J].Otolaryngol Head Neck Surg,2016,154(1):52-58.
[4] Desnoyers L R,Pai,Ferrando R E,et al.Targeting Fgf19 inhibits tumor growth in colon cancer xenograft and Fgf19 transgenic hepatocellular carcinoma models[J].Oncogene,2008,7(1):85-97.
[5] Feng S,Dakhova O,Creighton C J,et al.Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression[J].Cancer Res,2013,73(8):2551-2562.
[6] Sawey E T,Chanrion M,Cai C,et al.Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening[J].Cancer Cell,2011,19(3):347-358.
[7] Beenken A,Mohammadi M.The FGF family:biology,pathophysiology and therapy[J].Nat Rev Drug Discov,2009,8(3):235-253.
[8] Wu X,Li Y.Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities[J].Adv Exp Med Biol,2012(728):195-213.
[9] Hu L L,Cong L X.Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer[J].Oncology reports,2015,34(5):2683-2691.
[10] Wang S,Zhao D Q,Tian R H,et al.FGF19 contributes to tumor progression in gastric cancer by promoting migration and invasion[J].Oncol Res,2016,23(4):197-203.
[11] Betge J,Pollheimer M J,Lindtner R A,et al.Intramural and extramural vascular invasion in colorectal cancer:prognostic significance and quality of pathology reporting[J].Cancer,2012,118(3):628-638.
[12] Hakan U U,Ebru D,Merih T,et al.Lack of relationships between FGF19 staining pattern,lymph node metastasis and locally invasive characteristics of the tumor in colorectal cancers[J].Asian Pac J Cancer Prev,2013,14(5):3151-3314.

備注/Memo

備注/Memo:
基金項目:福建省衛(wèi)生健康中青年骨干人才培養(yǎng)項目(2020GGB007)
1 通信作者、在職博士、主任醫(yī)師,主要從事胃腸腫瘤基礎(chǔ)與臨床研究工作,Email:[email protected]
更新日期/Last Update: 2023-08-15