80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]廖悅婷,楊芳年,王小燕,等.降鈣素原和C反應(yīng)蛋白在重癥病房膿毒血癥患者早期診斷中的應(yīng)用價(jià)值[J].福建醫(yī)藥雜志,2023,45(03):19-22.
　LIAO Yueting,YANG Fangnian,WANG Xiaoyan,et al.Application value of procalcitonin and C-reactive protein in the early diagnosis of sepsis patients in intensive care unit[J].FUJIAN MEDICAL JOURNAL,2023,45(03):19-22.
點(diǎn)擊復(fù)制

降鈣素原和C反應(yīng)蛋白在重癥病房膿毒血癥患者早期診斷中的應(yīng)用價(jià)值()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年03期
頁(yè)碼:
19-22
欄目:
臨床研究
出版日期:
2023-06-15

文章信息/Info

Title:
Application value of procalcitonin and C-reactive protein in the early diagnosis of sepsis patients in intensive care unit
文章編號(hào):
1002-2600(2023)03-0019-04
作者:
廖悅婷; 楊芳年; 王小燕1; 郭玉嵩2
廈門大學(xué)附屬中山醫(yī)院臨床輸血科(廈門 361004)
Author(s):
LIAO Yueting;  YANG Fangnian;  WANG Xiaoyan;  GUO Yusong
Department of Blood Transfusion, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, China
關(guān)鍵詞:
降鈣素原;  C反應(yīng)蛋白;  膿毒血癥;  病原菌;  革蘭陰性菌;  革蘭陽(yáng)性菌
Keywords:
procalcitonin;  C-reactive protein;  sepsis;  pathogens;  Gram-negative bacteria;  Gram-positive bacteria
分類號(hào):
R446.1
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討降鈣素原(PCT)和C反應(yīng)蛋白(CRP)在重癥病房膿毒血癥患者早期診斷中的應(yīng)用價(jià)值。方法 選取2020年1月至2022年2月我院ICU收治的165例膿毒血癥患者,分析病原菌的分布,比較革蘭陰性菌感染者和革蘭陽(yáng)性菌感染者的臨床指標(biāo)差異,分析各臨床指標(biāo)對(duì)區(qū)分革蘭陰性菌感染者和革蘭陽(yáng)性菌感染者的靈敏度和特異度以及相互間的相關(guān)性。數(shù)據(jù)采用GraphPad軟件進(jìn)行顯著性差異和ROC曲線分析,Spearman秩相關(guān)法進(jìn)行相關(guān)性分析。結(jié)果 165例患者共檢出212株病原菌,革蘭陰性菌占48.59%,革蘭陽(yáng)性菌占42.45%,真菌占8.96%; 絕大部分患者的PCT和CRP水平均高于正常范圍,PCT、CRP水平在革蘭陰性感染組和革蘭陽(yáng)性感染組間差異有統(tǒng)計(jì)學(xué)意義(P<0.05),且兩者呈正相關(guān)(r>0.3),革蘭陰性菌感染者的PCT和CRP平均水平顯著高于革蘭陽(yáng)性菌感染者; PCT水平高于(28.42±38.87)ng/mL時(shí)感染革蘭陰性菌概率高,同時(shí),CRP水平高于(148.29±91.45)mg/L時(shí)感染菌較可能為常見(jiàn)的肺炎克雷伯菌、大腸埃希菌或鮑曼不動(dòng)桿菌的其中一種。結(jié)論 PCT和CRP對(duì)膿毒血癥的早期診斷具有重要價(jià)值,高水平的PCT和CRP有助于臨床醫(yī)生對(duì)疑似膿毒血癥患者進(jìn)行及時(shí)決策并指導(dǎo)抗菌藥物的合理使用。
Abstract:
Objective To explore the application value of procalcitonin(PCT)and C-reactive protein(CRP)in the early diagnosis of patients with sepsis in intensive care unit(ICU). Methods A total of 165 patients with sepsis admitted to our hospital from January 2020 to February 2022 were enrolled,the clinical parameters between the patients with Gram-negative bacteria and those with Gram-positive bacteria were compared, and the correlation between various clinical parameters was evaluated. The data were analyzed by using GraphPad software for ROC curves and significant difference analysis and Spearman method for correlation analysis. Results A total of 212 pathogenic bacteria were detected in 165 patients: 48.59% were Gram-negative bacteria, 42.45% were Gram-positive bacteria, and 8.96% were fungi; the levels of PCT and CRP in the vast majority of patients were abnormally high, and the levels of PCT and CRP were significantly different between the Gram-negative group and the Gram-positive group(P<0.05), and the levels of PCT and CRP were positively correlated(r>0.3).The mean levels of PCT and CRP in patients with Gram-negative bacteria were significantly higher than those with Gram-positive bacteria.When PCT level was higher than(28.42±38.87)ng/mL, the probability of infection with Gram-negative bacteria was high. And at the same time, when the CRP level was higher than(148.29±91.45)mg/L,the infected bacteria might be one of Klebsiella pneumoniae, Escherichia coli or Acinetobacter baumannii. Conclusion PCT and CRP may be used for diagnosis of sepsis. A high level of PCT and CRP can help clinicians make timely decisions to use antibiotics appropriately in patients with suspected sepsis.

參考文獻(xiàn)/References:

[1] Morello L G,Dalla-Costa L M,Fontana R M, et al.Assessment of clinical and epidemiological characteristics of patients with and without sepsis in intensive care units of a tertiary hospital[J].Einstein(Sao Paulo),2019,17(2):eAO4476.
[2] Long Y, Zhang Y, Gong Y, et al. Diagnosis of sepsis with cell-free DNA by next-generation sequencing technology in ICU patients[J]. Arch Med Res, 2016,47(5):365-371.
[3] 朱逸敏,張文宏.二代測(cè)序在膿毒血癥患者病原學(xué)診斷中的應(yīng)用[J].微生物與感染,2018,13(2):97-101.
[4] Liu V X, Fielding-Singh V, Greene J D, et al.The timing of early antibiotics and hospital mortality in sepsis[J]. Am J Respir Crit Care Med, 2017,196(7):856-863.
[5] Fraunberger P, Wang Y, Holler E,et al. Prognostic value of interleukin 6,procalcitonin,and C-reactive protein levels in intensive care unit patients during first increase of fever[J].2006, 26(1):10-12.
[6] 孫嘯宇,陸宗慶,張金,等. 《拯救膿毒癥運(yùn)動(dòng):膿毒癥與膿毒性休克治療國(guó)際指南(2021)》摘譯與解讀[J]. 中國(guó)中西醫(yī)結(jié)合急救雜志, 2021, 28(6):8.
[7] 黃承照,周廣裕. 60例ICU室患者膿毒血癥病原菌分布及耐藥性分析[J]. 中國(guó)醫(yī)藥科學(xué), 2017, 7(19):4.
[8] 王晶,馬娟,范云,等.2015～2017年陜西省人民醫(yī)院臨床血流感染病原菌的分布及耐藥性分析[J].現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志,2019,34(4):87-90,95
[9] 邸師紅,馬倩,代超,等.重癥監(jiān)護(hù)病房膿毒血癥患者病原學(xué)分布及死亡高危因素分析[J].現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志,2020,35(3):141-145.
[10] 張曼佳.2017～2019年某院膿毒血癥患者原菌菌種鑒定及藥敏試驗(yàn)結(jié)果分析[J].中國(guó)當(dāng)代醫(yī)藥,2021,28(17):199-202.
[11] Schuetz P, Bretscher C, Bernasconi L, et al. Overview of procalcitonin assays and procalcitonin-guided protocols for the management of patients with infections and sepsis[J]. Expert Rev Mol Diagn,2017,17(6):593-601.
[12] Linscheid P, Seboek D, Nylen E S, et al. In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue[J]. Endocrinology, 2003, 144(12):5578-5584.
[13] 桂水清,馮永文,吳明,等. C-反應(yīng)蛋白與降鈣素原對(duì)重癥監(jiān)護(hù)病房老年患者感染的監(jiān)測(cè)[J]. 中華危重病急救醫(yī)學(xué),2013,25(4):244-245.
[14] Póvoa P. C-reactive protein: a valuable marker of sepsis[J]. Intensive Care Med, 2002,28(3):235-243.
[15] 黃新文,王晉鵬,李海林.血清C-反應(yīng)蛋白與降鈣素原水平對(duì)細(xì)菌性膿毒癥的診斷價(jià)值[J].中華醫(yī)學(xué)雜志,2014,94(27):2106-2109.
[16] 信淑珍,王愛(ài)琴,李燕燕,等.膿毒血癥患者炎癥因子水平與疾病嚴(yán)重程度的關(guān)系分析[J].中華醫(yī)院感染學(xué)雜志,2016,26(16):3616-3618.
[17] Liu H H, Zhang M W, Guo J B, et al. Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either Gram-negative or Gram-positive bacteria[J]. Ir J Med Sci,2017,186(1):207-212.

相似文獻(xiàn)/References:

[1]張紹潔,閻國(guó)輝,甘書芬.冠狀動(dòng)脈Z值等四聯(lián)指標(biāo)模型對(duì)黏膜皮膚淋巴結(jié)綜合征的輔助診斷價(jià)值[J].福建醫(yī)藥雜志,2024,46(04):13.[doi:10.20148/j.fmj.2024.04.004]
　ZHANG Shaojie,YAN Guohui,GAN Shufen.Auxiliary diagnostic value of coronary artery Z-value and other quadruple index model for mucocutaneous lymph node syndrome[J].FUJIAN MEDICAL JOURNAL,2024,46(03):13.[doi:10.20148/j.fmj.2024.04.004]

備注/Memo

備注/Memo:
1 廈門大學(xué)附屬中山醫(yī)院藥學(xué)部; 2 通信作者,Email:[email protected]
更新日期/Last Update: 2023-06-15