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[1]石小松,楊芳.不同血漿N端腦鈉肽前體界值對(duì)川崎病的診斷價(jià)值[J].福建醫(yī)藥雜志,2023,45(02):5-8.
　SHI Xiaosong,YANG Fang.Significance of different cut-off values of N-terminal pro-brain natriuretic peptide in the diagnosis of Kawasaki disease[J].FUJIAN MEDICAL JOURNAL,2023,45(02):5-8.
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不同血漿N端腦鈉肽前體界值對(duì)川崎病的診斷價(jià)值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年02期
頁(yè)碼:
5-8
欄目:
臨床研究
出版日期:
2023-04-15

文章信息/Info

Title:
Significance of different cut-off values of N-terminal pro-brain natriuretic peptide in the diagnosis of Kawasaki disease
文章編號(hào):
1002-2600(2023)02-0005-04
作者:
石小松; 楊芳1
福建省立醫(yī)院南院兒科（福州 350028）
Author(s):
SHI Xiaosong;  YANG Fang
Department of Pediatrics, Fujian Provincial Hospital South Branch, Fuzhou, Fujian 350028, China
關(guān)鍵詞:
N端腦鈉肽前體; 川崎病; 界值
Keywords:
N-terminal pro-brain natriuretic peptide; Kawasaki disease;  cut-off value
分類號(hào):
R725.4
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討不同血漿N端腦鈉肽前體（NT-proBNP）界值對(duì)川崎病（KD）的診斷價(jià)值。方法 選取299例KD患兒作為觀察組，將同期住院的107名發(fā)熱患兒作為對(duì)照組，按年齡分層，比較不同組間兒童一般臨床特征及血漿NT-proBNP水平，運(yùn)用受試者工作特征曲線（ROC曲線）及曲線下面積（AUC），分析不同NT-proBNP界值對(duì)KD的診斷意義。結(jié)果 KD組NT-proBNP高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.001）。根據(jù)ROC曲線，NT-proBNP診斷KD的最佳界值為320.14 pg/mL，Youden指數(shù)為0.61；3～12月齡KD組NT-proBNP高于＞12月齡KD組（P<0.05），3～12月齡組與＞12月齡組診斷KD的最佳界值分別為356.42 pg/mL和209.33 pg/mL。結(jié)論 血漿NT-proBNP對(duì)KD有一定的診斷價(jià)值，在不同年齡組KD患兒有不同的最佳診斷界值。
Abstract:
Objective To investigate the diagnostic value of different cut-off values of plasma N-terminal pro-brain natriuretic peptide in Kawasaki disease(KD). Methods A total of 299 children with KD were selected as the observation group, 107 patients who were hospitalized during the same period were used as the control group, and stratified according to age. The general clinical characteristics and plasma NT-proBNP levels of children in different groups were compared, and the receiver operating characteristic curve (ROC curve) and area under the curve (AUC) were used to analyze the diagnostic significance of different NT-proBNP thresholds for KD. Results The plasma NT-proBNP level in the KD group was higher than that in the control group, showing a statistically significant difference (P<0.001). According to the ROC analysis, the optimal cut-off value of NT-proBNP for diagnosing KD was 320.14 pg/mL, the Youdens index was 0.61. The plasma NT-proBNP level in the 3-12 months group was higher than that in the >12 months group, showing a statistically significant difference (P<0.05). The ideal NT-proBNP cut-off levels for diagnosing KD in the 3-12 months group and the >12 months group were 356.42 pg/mL and 209.33 pg/mL, respectively.Conclusion The plasma NT-proBNP had certain diagnostic value for KD, showing different thresholds in children with KD in different age groups.

參考文獻(xiàn)/References:

[1] Xie L P,Yan W L,Huang M,et al.Epidemiologic features of Kawasaki disease in Shanghai from 2013 through 2017[J].J Epidemiol,2020,30(10):429-435.
[2] Mccrindle B W,Rowley A H,Newburger J W,et al.Diagnosis,treatment,and long-term management of Kawasaki disease: A scientific statement for health professionals from the American Heart Association[J].Circulation,2017,135(17):e927-e999.
[3] Kwon H,Lee J H,Jung J Y,et al.N-terminal pro-brain natriuretic peptide can be an adjunctive diagnostic marker of hyper-acute phase of Kawasaki disease[J].Eur J Pediatr,2016,175(12):1997-2003.
[4] Kobayashi T,Ayusawa M,Suzuki H,et al.Revision of diagnostic guidelines for Kawasaki disease (6th revised edition)[J].Pediatr Int,2020,62(10):1135-1138.
[5] 盧曉穎.川崎病生物學(xué)標(biāo)志物研究進(jìn)展[J].國(guó)際兒科學(xué)雜志,2020,47:14-17.
[6] Yanagisawa D,Ayusawa M,Kato M,et al.Factors affecting N-terminal pro-brain natriuretic peptide elevation in the acute phase of Kawasaki disease[J].Pediatr Int,2016,58(11):1105-1111.
[7] Hu P,Jiang GM,Wu Y,et al.TNF-α is superior to conventional inflammatory mediators in forecasting IVIG nonresponse and coronary arteritis in Chinese children with Kawasaki disease[J].Clin Chim Acta,2017,471:76-80.
[8] 武萬(wàn)良,蔣寧,史延,等.N端腦利鈉肽前體在川崎病急性期的變化及臨床價(jià)值[J].中國(guó)小兒急救醫(yī)學(xué),2016,23:561-564.
[9] 李勝,陳營(yíng),馮愛(ài)民.NT-proBNP及其在川崎病中的臨床意義研究進(jìn)展[J].國(guó)際兒科學(xué)雜志,2019,46:499-502.
[10] Rodriguez-Gonzalez M,Perez-Reviriego A A,Castellano-Martinez A,et al.N-terminal probrain natriuretic peptide as biomarker for diagnosis of Kawasaki disease[J].Biomark Med,2019,13(4):307-323.
[11] Lin K H,Chang S S,Yu C W,et al.Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis[J].BMJ Open,2015,5(4):e6703.
[12] 黎賽,周舟,胡彬,等.0～18歲健康人群的血清N末端腦鈉肽前體參考值范圍研究[J].醫(yī)學(xué)臨床研究,2015,32(4):665-667.

備注/Memo

備注/Memo:
1 福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院兒科（福州 350001）,通信作者，Email：[email protected]
更新日期/Last Update: 2023-04-15