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[1]張國(guó)棟,潘東明,楊輝,等.平脂顆粒對(duì)非酒精性脂肪肝大鼠血脂和肝脂代謝的影響[J].福建醫(yī)藥雜志,2023,45(01):102-106.
　Zhang Guodong,Pan Dongming,Yang Hui,et al.Effect of Pingzhi granule on hepatic lipid metabolism of NAFLD in rats[J].FUJIAN MEDICAL JOURNAL,2023,45(01):102-106.
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平脂顆粒對(duì)非酒精性脂肪肝大鼠血脂和肝脂代謝的影響()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年01期
頁(yè)碼:
102-106
欄目:
基礎(chǔ)研究
出版日期:
2023-02-15

文章信息/Info

Title:
Effect of Pingzhi granule on hepatic lipid metabolism of NAFLD in rats
文章編號(hào):
1002-2600(2023)01-0102-05
作者:
張國(guó)棟; 潘東明; 楊輝; 戚歡陽(yáng); 楊玲敏; 連周穎; 黃文傳1; 黃亦琦1
廈門市醫(yī)藥研究所(廈門 361008)
Author(s):
Zhang Guodong; Pan Dongming; Yang Hui; Qi Huangyang; Yang Lingmin; Lian Zhouyin; Huang Wenchuan; Huang Yiqi
Xiamen Institute of Medicine, Xiamen, Fujian 361008, China
關(guān)鍵詞:
非酒精性脂肪肝;  平脂顆粒;  大鼠;  肝脂;  血脂
Keywords:
non-alcoholic fatty liver;  Pingzhi granules;  rats;  liver lipids;  blood lipids
分類號(hào):
R285.5; R575.5
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討平脂顆粒對(duì)非酒精性脂肪肝(NAFLD)模型大鼠的治療作用及機(jī)制。方法 將造模成功的60只SD大鼠隨機(jī)分為空白組、模型組、對(duì)照組、平脂顆粒低、中、高劑量治療組,對(duì)照組使用當(dāng)飛利肝寧膠囊懸濁液灌胃; 待實(shí)驗(yàn)結(jié)束時(shí)檢測(cè)各組大鼠肝功、血脂和抗氧化應(yīng)激指標(biāo)。結(jié)果 模型組血液和肝臟中的ALT、AST、TC、TG、LDL-C較空白組均升高,HDL-C明顯降低(P<0.01),顯示造模成功; 治療組血清和肝臟中ALT、AST、TC、TG、LDL-C的含量與模型組比較均下降(P<0.01或P<0.05),且平脂顆粒高劑量組HDL-C升高明顯(P<0.05); 另外與模型組比較,平脂顆粒中、高劑量治療組血清MDA下降、SOD升高(P<0.01或P<0.05),病理學(xué)觀察顯示平脂顆粒組能減緩治療組脂肪肝病變程度,肝細(xì)胞脂肪變性及炎性細(xì)胞浸潤(rùn)較模型組均有明顯改善。結(jié)論 平脂顆粒可以通過提高肝脂和血脂代謝水平,減少肝臟過氧化損傷,對(duì)NAFDL有良好的治療作用。
Abstract:
Objective To investigate the effect and the mechanism of Pingzhi granules on prevention and treatment to nonalcoholic fatty liver disease in SD rats with high-fat diet.Methods Healthy SD rats without specific pathogens were fed with high-fat diet for 6 weeks to replicate NAFLD animal model.Pingzhi Granules were used for intervention,and Dangfei Liganning Capsule was used as positive control drug,which was administrated by gavage continuously.At the end of the experiment,liver function,blood lipid and antioxidant stress were detected and pathological examination was conducted.Results Compared with the control group,model group showed raising AST,ALT,TC,TG,and LDL-C both in blood lipid and liver lipid(P<0.01); Compared with the model group,a certain dose of pingzhi granules can not only reduce the body weight,liver wet weight and liver index of NAFLD rats but also regulate blood lipid and liver lipid(reducing TC,TG,LDL-C,ALT,AST(P<0.01 or P<0.05),increasing HDL-C(P<0.05); In the treatment group of medium and high dose group,MDA content decreased and SOD content increased(P<0.01 or P<0.05). Pathological results showed that the hepatocellular steatosis and inflammatory cell infiltration in the treatment group were significantly improved compared with the model group.Conclusion Pingzhi granules have good therapeutic effects on NAFLD not only by promoting lipid metabolism and liver function,but also reducing lipid peroxidation damage.

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備注/Memo

備注/Memo:
基金項(xiàng)目:廈門市科技局科技計(jì)劃項(xiàng)目(3502Z20184055); 福建省衛(wèi)生計(jì)生委中青年骨干人才培養(yǎng)項(xiàng)目(2018ZQN95)
1 廈門市中醫(yī)院(廈門 361009)
作者簡(jiǎn)介:張國(guó)棟,男(1986～),博士,講師,主要從事天然藥物開發(fā)和生理學(xué)研究,Email:[email protected];
黃亦琦(1963～),通信作者,主任醫(yī)師,主要從事脂代謝病臨床基礎(chǔ)研究,Email:[email protected]
更新日期/Last Update: 2023-02-15