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[1]霍然,李俊毅,陳麗妹,等.2016-2020年腫瘤患者銅綠假單胞菌感染及耐藥趨勢(shì)分析[J].福建醫(yī)藥雜志,2023,45(01):19-22.
　HUO Ran,LI Junyi,CHEN Limei,et al.Retrospective study of pseudomonas aeruginosa infection and drug resistance in tumor patients from 2016 to 2020[J].FUJIAN MEDICAL JOURNAL,2023,45(01):19-22.
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2016-2020年腫瘤患者銅綠假單胞菌感染及耐藥趨勢(shì)分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
45
期數(shù):
2023年01期
頁(yè)碼:
19-22
欄目:
臨床研究
出版日期:
2023-02-15

文章信息/Info

Title:
Retrospective study of pseudomonas aeruginosa infection and drug resistance in tumor patients from 2016 to 2020
文章編號(hào):
1002-2600(2023)01-0019-04
作者:
霍然; 李俊毅1; 陳麗妹; 辛娜; 陳巖松; 陳燕2
福建醫(yī)科大學(xué)腫瘤臨床醫(yī)學(xué)院 福建省腫瘤醫(yī)院(福州 350014)
Author(s):
HUO Ran;  LI Junyi;  CHEN Limei;  XIN Na;  CHEN Yansong;  CHEN Yan
Fujian Cancer Hospital, Clinical Oncology School of Fujian Medical University, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
銅綠假單胞菌;  腫瘤患者;  耐藥性;  抗生素
Keywords:
pseudomonas aeruginosa;  tumor patient;  antibiotic resistance;  antibiotics
分類號(hào):
R378
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討腫瘤患者感染銅綠假單胞菌(PA)的臨床分布、耐藥趨勢(shì),為腫瘤患者PA感染治療提供依據(jù)。方法 回顧性分析2016-2020年我院臨床標(biāo)本分離出PA的腫瘤患者的臨床資料及藥敏試驗(yàn)數(shù)據(jù)。結(jié)果 2016年1月至2020年12月我院共分離出PA 926株,臨床患者標(biāo)本來(lái)源主要為呼吸道標(biāo)本(65.12%)。2016—2020年我院PA對(duì)亞胺培南的總體耐藥率為31.42%,對(duì)美羅培南的總體耐藥率為23.11%,對(duì)慶大霉素、環(huán)丙沙星、頭孢他啶的總體耐藥率分別為8.74%、16.41%、15.23%,對(duì)頭孢吡肟、左氧氟沙星、哌拉西林、哌拉西林/他唑巴坦的總體耐藥率分別為10.48%、13.39%、12.20%、11.12%。我院PA分離率與細(xì)菌耐藥監(jiān)測(cè)官網(wǎng)(CHINET網(wǎng),http://www.chinets.com)監(jiān)測(cè)數(shù)據(jù)差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05); 但對(duì)亞胺培南耐藥率高于CHINET監(jiān)測(cè)數(shù)據(jù),對(duì)左氧氟沙星、頭孢吡肟、哌拉西林、哌拉西林/他唑巴坦耐藥率低于CHINET監(jiān)測(cè)數(shù)據(jù)(均P<0.05)。結(jié)論 PA是我院內(nèi)檢出率較高的條件致病菌之一,應(yīng)高度警惕耐藥菌株的產(chǎn)生。我院PA對(duì)常用抗生素耐藥呈下降趨勢(shì); 但對(duì)于某些抗生素耐藥性高于同一時(shí)期CHINET監(jiān)測(cè)數(shù)據(jù)。臨床工作中應(yīng)密切監(jiān)測(cè)腫瘤患者PA感染及耐藥情況,同時(shí)在治療中合理使用抗菌藥物,預(yù)防耐藥菌株的產(chǎn)生。
Abstract:
Objective To explore the clinical distribution and drug resistance trend of pseudomonas aeruginosa(PA) infection in tumor patients, and to provide evidence for the treatment of PA infection in tumor patients.Methods Clinical data and drug sensitivity test data on tumor patients with PA isolated from clinical specimens in our hospital from 2016 to 2020 were analyzed retrospectively.Results A total of 926 PA were detected from Jan.2016 to Dec.2020.The specimens were mainly from respiratory tract(65.12%).From 2016 to 2020, the overall drug resistance rate of PA in our hospital to imipenem was 31.42% and the overall drug resistance rate to meropenem was 23.11%.The overall drug resistance rates to gentamicin, ciprofloxacin and ceftazidime were 8.74%, 16.41% and 15.23%, respectively.There was no significant difference between the isolated rate of PA from our hospital and data on the official website of bacterial resistance monitoring(CHINET, http://www.chinets.com), while the drug resistance rate to imipenem is higher than that of CHINET data and the drug resistance rate to levofloxacin, cefepime, piperacillin, piperacillin/tazobactam were all lower than the data on CHINET.Conclusion We should be highly alert to the emergence of drug-resistant strains because PA was one of the conditional pathogens with high detection rate in our hospital.The resistance of PA isolated from our hosptial to common antibiotics was declining but the drug resistance to some antibiotics was higher than that of CHINET in the same period.In clinical work, we should monitor the PA infection and drug resistance in tumor patients closely, and at the same time, we should use antibiotics reasonably to prevent the emergence of drug resistant strains in the treatment of PA infection.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
1 福建醫(yī)科大學(xué)醫(yī)學(xué)技術(shù)與工程學(xué)院; 2 通信作者,Email:[email protected]
更新日期/Last Update: 2023-02-15