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[1]蘇林丘,黃麗蓉,劉磊磊,等.經(jīng)顱多普勒發(fā)泡試驗及經(jīng)胸右心造影篩查卵圓孔未閉的應(yīng)用價值[J].福建醫(yī)藥雜志,2022,44(06):12-16.
　SU Linqiu,HUANG Lirong,LIU Leilei,et al.Application value of contrast transcranial Doppler and contrast transthoracic echocardiography in screeningpatent foramen ovale[J].FUJIAN MEDICAL JOURNAL,2022,44(06):12-16.
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經(jīng)顱多普勒發(fā)泡試驗及經(jīng)胸右心造影篩查卵圓孔未閉的應(yīng)用價值()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年06期
頁碼:
12-16
欄目:
臨床研究
出版日期:
2022-12-15

文章信息/Info

Title:
Application value of contrast transcranial Doppler and contrast transthoracic echocardiography in screeningpatent foramen ovale
文章編號:
1002-2600（2022）06-0012-05
作者:
蘇林丘; 黃麗蓉; 劉磊磊; 歐陽秋芳; 郭敏慧; 黃曉峰1
福建中醫(yī)藥大學(xué)附屬第二人民醫(yī)院（福州 350003）
Author(s):
SU Linqiu; HUANG Lirong; LIU Leilei; OUYANG Qiufang; GUO Minhui; HUANG Xiaofeng
The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine，F(xiàn)uzhou,Fujian 350003，China
關(guān)鍵詞:
經(jīng)顱多普勒發(fā)泡; 經(jīng)胸右心造影; 卵圓孔未閉
Keywords:
contrast transcranial Doppler; contrast transthoracic echocardiography; patent foramen ovale
分類號:
R540.45；R445.1；R741
文獻標志碼:
B
摘要:
目的 探討經(jīng)顱多普勒發(fā)泡試驗（cTCD）及經(jīng)胸右心造影（cTTE）篩查卵圓孔未閉（PFO）的應(yīng)用價值。方法 回顧性分析我院神經(jīng)內(nèi)科不明原因腦卒中、黑朦、偏頭痛185例患者，所有患者均行普通經(jīng)胸超聲心動圖（TTE）、cTTE及cTCD，其中46例并行經(jīng)食道超聲心動圖（TEE）檢查。以TEE為金標準，比較TTE、cTTE、cTCD 3種方法檢測PFO的效能。結(jié)果 cTCD對PFO的檢出率是71.4%、敏感度是94.1%、特異度是75.0%；cTTE對PFO的檢出率是57.3%、敏感度是73.4%、特異度是91.7%；TTE對PFO的檢出率是21.6%，敏感度是26.5%、特異度是41.7%。cTCD及cTTE對PFO的檢出率、敏感度及特異度均明顯高于TTE；cTCD的敏感度高于cTTE，但特異度低于cTTE。cTCD檢測少量右向左分流（RLS）的能力高于cTTE；但cTCD與cTTE診斷中大量RLS的能力差異無統(tǒng)計學(xué)意義。結(jié)論 cTCD對PFO的檢出率、敏感度較高，但特異度較cTTE低，無法判別RLS的位置，有一定的假陽性；cTTE診斷PFO的特異度極高，但敏感度較cTCD低，有一定的假陰性。
Abstract:
Objective To explore the application value of contrast transcranial Doppler and contrast transthoracic echocardiography in screening patent foramen ovale(PFO). Methods A total of 185 patients with stroke of unknown cause, amaurosis, migraine in the department of neurology of our hospital were analyzed retrospectively. All the patients were given transthoracic echocardiograph (TTE), contrast transthoracic echocardiography (cTTE) and contrast transcranial doppler(cTCD). Forty-six patients were also given transesophageal echocardiography (TEE) examination. Taken TEE outcomes as golden standards, the efficacies of TTE, cTTE and cTCD for diagnosing PFO were compared. Results The detection rate, sensitivity and specificity of cTCD were 71. 4%, 94. 1% and 75. 0% respectively; the detection rate, sensitivity and specificity of cTTE were 57. 3%, 73. 4% and 91. 7% respectively; the detection rate, sensitivity and specificity of TTE were 21. 6%, 26. 5% and 41. 7% respectively. The detection rate, sensitivity and specificity of cTCD and cTTE were significantly higher than those of TTE. cTCD were more sensitive than cTTE, but less specific than cTTE. The ability of cTCD for detecting small amount of right-to-left shunt (RLS) were higher than that of cTTE. However, there were no difference between cTCD and cTTE in the ability for detecting medium and large number of RLS. Conclusion cTCD has higher detection rate and sensitivity for diagnosing PFO, but its specificity is lower than that of cTTE, and it is difficult to detect the location of RLS and has certain false positive. The specificity of cTTE for diagnosing PFO is very high, but its sensitivity is lower than that of cTCD, with certain false negative.

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備注/Memo

備注/Memo:
基金項目：福建省衛(wèi)健委科技計劃項目青年科研課題（2020QNA064）
1 通信作者，Email:[email protected]
更新日期/Last Update: 2022-12-15