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[1]魏長順,查小云,謝良孝,等.單核細(xì)胞/高密度脂蛋白膽固醇比值與糖尿病足潰瘍的相關(guān)性分析[J].福建醫(yī)藥雜志,2022,44(06):9-12.
　WEI Changshun,ZHA Xiaoyun,XIE Liangxiao,et al.Analysis on correlation between monocyte to high density lipoprotein-cholesterol ratio and diabetic foot ulcer[J].FUJIAN MEDICAL JOURNAL,2022,44(06):9-12.
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單核細(xì)胞/高密度脂蛋白膽固醇比值與糖尿病足潰瘍的相關(guān)性分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年06期
頁碼:
9-12
欄目:
臨床研究
出版日期:
2022-12-15

文章信息/Info

Title:
Analysis on correlation between monocyte to high density lipoprotein-cholesterol ratio and diabetic foot ulcer
文章編號:
1002-2600（2022）06-0009-04
作者:
魏長順; 查小云; 謝良孝; 賴鵬斌
福建醫(yī)科大學(xué)附屬漳州市醫(yī)院內(nèi)分泌代謝一科（漳州 363000）
Author(s):
WEI Changshun; ZHA Xiaoyun; XIE Liangxiao; LAI Pengbin
The First Department of Endocrinology and Metabolism，the Affiliated Zhangzhou Municipal Hospital，F(xiàn)ujian Medical University，Zhangzhou，F(xiàn)ujian 363000，China
關(guān)鍵詞:
單核細(xì)胞/高密度脂蛋白膽固醇比值; 糖尿病足潰瘍
Keywords:
monocyte to high density lipoprotein-cholesterol ratio;  diabetic foot ulcer
分類號:
R587.2
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 分析新型炎癥指標(biāo)單核細(xì)胞/高密度脂蛋白膽固醇比值（MHR）與糖尿病足潰瘍（DFU）的關(guān)系。方法 回顧性分析我院120例糖尿病患者的臨床資料，其中單純糖尿病40例，DFU 80例作為研究對象，記錄年齡、病程、體質(zhì)量、血壓、血常規(guī)、糖脂代謝、肝腎功能、CRP等指標(biāo)，以及足潰瘍感染嚴(yán)重程度。分析MHR與DFU之間的關(guān)系； logistic回歸模型分析DFU的影響因素；ROC曲線評價MHR預(yù)測DFU的最佳截斷值及其特異性和敏感性。結(jié)果 DFU組年齡較大，BMI、TG、ALB、淋巴細(xì)胞、Hb較低，CRP、單核細(xì)胞、MHR均較高；Spearman相關(guān)分析顯示MHR與年齡、WBC、中性粒細(xì)胞、血肌酐、CRP正相關(guān)，與Hb、TC、LDL、ALB負(fù)相關(guān)；二元logistic回歸分析顯示， MHR是DFU重要的危險因素[OR=10.191（95%CI：2.023，51.349），P=0.005]。對DFU的預(yù)測價值，受試者工作特征曲線分析顯示，MHR 最佳截斷值為0.613 9， MHR的曲線下面積為 0.663（95%CI：0.560，0.766）， 預(yù)測的敏感性為 53.7%、特異性為 86.1%。CRP最佳截斷值為 3.580 0，CRP 的曲線下面積為 0.791（95%CI：0.706，0.876），預(yù)測的敏感性為 68.7%，特異性為 83.3%。結(jié)論 MHR與DFU的發(fā)生發(fā)展密切相關(guān)，臨床上關(guān)注MHR對預(yù)測糖尿病患者發(fā)生糖尿病足可能具有一定的臨床指導(dǎo)意義。
Abstract:
Objective To analyze the relationship between monocyte to high density lipoprotein-cholesterol ratio, a novel inflammatory marker, and diabetic foot ulcer. Methods A retrospective study on clinic data of 120 patients with diabetes who were hospitalized in Zhangzhou Municipal Hospital was conducted, including 40 patients with diabetes alone and 80 patients with diabetic foot ulcer. Age, disease duration, weight, blood pressure, blood routine, glucose and lipids metabolism, hepatic and renal function, C-reactive protein (CRP) and other indexes, and the severity of foot ulcer infection were recorded. The relationship between MHR and diabetic foot ulcer was analyzed. Logistic regression model was used to analyze the influencing factors of diabetic foot ulcer. ROC curve was used to evaluate the optimal cut-off value, specificity and sensitivity of MHR in predicting diabetic foot ulcers. Results Diabetic foot ulcer group was older with lower BMI, TG, ALB, Lymphocyte, Hb and higher CRP, Monocyte, MHR. Spearman correlation analysis showed that MHR was positively correlated with age, WBC, Neutrophils, serum creatinine and CRP, and negatively correlated with Hb, TC, LDL and ALB. Binary logistic regression analysis showed that MHR was independent risk factor for diabetic foot ulcer[OR=10. 191（95%CI：2. 023, 51. 349）, P=0. 005]. Receiver operating characteristic curve analysis showed that the optimal cut-off value of MHR for predicting diabetic foot ulcer was 0. 613 9, the area under the curve of MHR was 0. 663 (95%CI: 0. 560, 0. 766), the sensitivity of prediction was 53. 7%, and the specificity was 86. 1%. The optimal cutoff value of CRP was 3. 5800, the area under the curve of CRP was 0. 791 (95%CI: 0. 706, 0. 876), the sensitivity of prediction was 68. 7%, and the specificity was 83. 3%. Conclusion MHR is closely related to the occurrence and development of diabetic foot ulcers. Clinical attention to MHR may have certain clinical guiding significance for predicting the occurrence of diabetic foot in diabetic patients.

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更新日期/Last Update: 2022-12-15