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[1]陳遠(yuǎn)翔,林斌,陳東杰,等.不停跳冠脈搭橋術(shù)后差異基因的生信分析[J].福建醫(yī)藥雜志,2022,44(06):6-8.
　CHEN Yuanxiang,LIN Bin,CHEN Dongjie,et al.Bioinformatics analysis of differential expression genes after off-pump coronary artery bypass grafting[J].FUJIAN MEDICAL JOURNAL,2022,44(06):6-8.
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不停跳冠脈搭橋術(shù)后差異基因的生信分析()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年06期
頁碼:
6-8
欄目:
臨床研究
出版日期:
2022-12-15

文章信息/Info

Title:
Bioinformatics analysis of differential expression genes after off-pump coronary artery bypass grafting
文章編號:
1002-2600（2022）06-0006-03
作者:
陳遠(yuǎn)翔; 林斌; 陳東杰; 林先東; 翁國星1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院心血管外科（福州 350001）
Author(s):
CHEN Yuanxiang; LIN Bin; CHEN Dongjie; LIN Xiandong; WENG Guoxing
Department of Cardiovascular Surgery,Fujian Provincial Hospital，Shengli Clinical Medical College of Fujian Medical University，F(xiàn)ujian provincial hospital，F(xiàn)uzhou，F(xiàn)ujian,350001,China
關(guān)鍵詞:
不停跳冠脈搭橋;  生信分析; 差異基因
Keywords:
off-pump coronary artery bypass grafting;  bioinformatics analysis; differential expression genes
分類號:
R541.4
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 通過生信分析探討不停跳冠脈搭橋(OPCAB)術(shù)后基因變化，并篩選關(guān)鍵（Hub）基因。方法 通過納入數(shù)據(jù)集GSE12485（心肌）和GSE4386（心房），使用R包對OPCAB術(shù)前術(shù)后心臟組織進(jìn)行差異分析，篩選差異基因（DEGs）。兩組DEGs交集得到共同DEGs進(jìn)一步分析，然后進(jìn)行GO和KEGG功能富集分析。最后使用STRING進(jìn)行蛋白質(zhì)-蛋白質(zhì)相互作用(PPI)分析，通過Cytoscape軟件中cytoHubba的Degree算法篩選Hub基因。結(jié)果 共獲得36個共同上調(diào)DEGs。GO和KEGG分析結(jié)果顯示，OPCAB術(shù)后主要與炎癥反應(yīng)相關(guān)。PPI網(wǎng)絡(luò)分析，并得到4個Hub基因。結(jié)論 炎癥反應(yīng)在OPCAB術(shù)后起重要作用,而4個Hub基因均具有重要的價值，將為后續(xù)研究提供依據(jù)。
Abstract:
Objective To investigate gene changes after off-pump coronary artery bypass grafting (OPCAB) by bioinformatics analysis, and to screen Hub genes. Methods By including the datasets GSE12485 (myocardium) and GSE4386 (atrium), the R package was used to analyze the differences in the preoperative and postoperative cardiac tissues of OPCAB to screen for differential genes (DEGs). The intersection of the two groups of DEGs was obtained with the common DEGs for further analysis. Then GO and KEGG functional enrichment analysis was performed. Finally, STRING was used for protein-protein interaction (PPI) analysis, and Hub genes were screened by Degree algorithm of cytoHubba with Cytoscape software. Results A total of 36 co-upregulated DEGs were obtained. GO and KEGG analysis showed that OPCAB was mainly associated with inflammation. PPI network analysis was performed, and four Hub genes with the highest score were obtained. Conclusion Inflammation plays an important role after OPCAB. All the four Hub genes are of great value, which will provide a basis for subsequent research.

參考文獻(xiàn)/References:

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備注/Memo

備注/Memo:
基金項目：福建省自然科學(xué)基金資助項目（2022J05066）
1 通信作者，Email:[email protected]
更新日期/Last Update: 2022-12-15