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[1]李業(yè)森.68Ga標(biāo)記TMTP1探針在肝癌腫瘤模型中的microPET/CT顯像研究[J].福建醫(yī)藥雜志,2022,44(05):122-124.
　Li Yesen.Study on microPET/CT imaging of 68GA-labeled TMTP1 probe in HCC tumor model[J].FUJIAN MEDICAL JOURNAL,2022,44(05):122-124.
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68Ga標(biāo)記TMTP1探針在肝癌腫瘤模型中的microPET/CT顯像研究()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年05期
頁(yè)碼:
122-124
欄目:
基礎(chǔ)研究
出版日期:
2022-10-15

文章信息/Info

Title:
Study on microPET/CT imaging of 68GA-labeled TMTP1 probe in HCC tumor model
作者:
李業(yè)森
廈門大學(xué)附屬第一醫(yī)院核醫(yī)學(xué)科（廈門 361003）
Author(s):
Li Yesen
Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian361003, China
關(guān)鍵詞:
PET; 肝癌; 68Ga[Ga]-NOTA-PEG2-TMTP1; 68Ga標(biāo)記
分類號(hào):
R735.7
文獻(xiàn)標(biāo)志碼:
A
摘要:
目的 研究68Ga[Ga]-NOTA-PEG2-TMTP1對(duì)SMMC-7721肝癌荷瘤小鼠模型的診斷效果。 方法 氨肽酶P2在一些腫瘤(如肝癌、肺癌、乳腺癌等)中有高表達(dá)。TMTP1可以特異性地靶向氨肽酶P2，本研究利用68Ga標(biāo)記NOTA-PEG2-TMTP1合成68Ga[Ga]-NOTA-PEG2-TMTP1，然后對(duì)SMMC-7721肝癌荷瘤小鼠進(jìn)行microPET/CT顯像研究，研究其對(duì)腫瘤的診斷效果。 結(jié)果 68Ga[Ga]-NOTA-PEG2-TMTP1的放射性標(biāo)記產(chǎn)率為87.16±1.23%，放化純度大于99.0%。實(shí)驗(yàn)證明相PEG修飾后的TMTP1，具有更好的腫瘤靶向性，腫瘤肌肉比可以高達(dá)5.66。 結(jié)論 對(duì)于肝癌的診斷來(lái)說(shuō)，68Ga[Ga]-NOTA-PEG2-TMTP1可能是更好的PET探針，具有進(jìn)一步臨床轉(zhuǎn)化的前景。
Abstract:
Objective To investigate the diagnostic effect of 68Ga[Ga]-NOTA-PEG2-TMTP1 on a mouse model of SMMC-7721 hepatocellular carcinoma in nude mice. Methods Aminopeptidase P2 was highly expressed in some tumors (e.g., liver, lung, breast cancer, etc.). TMTP1 could specifically target aminopeptidase P2. In this study, 68Ga[Ga]-NOTA-PEG2-TMTP1 was synthesized using 68Ga-labeled NOTA-PEG2-TMTP1, then SMMC-7721 hepatocellular carcinoma tumor-bearing nude mice for microPET/CT imaging study to investigate its diagnostic effect on tumors. Results The radiolabeling yield of 68Ga[Ga]-NOTA-PEG2-TMTP1 was 87.16±1.23%, and the radiochemical purity was greater than 99.0%.It was demonstrated that TMTP1, after phase PEG modification, had better tumor targeting, with tumor muscle ratio up to 5.66.Conclusion For the diagnosis of hepatocellular carcinoma, 68Ga[Ga]-NOTA-PEG2-TMTP1 may be a better PET probe with the prospect of further clinical translation.

參考文獻(xiàn)/References:

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[5] Yesen L, Deliang Z，Ying S, et al.Syntheses and preliminary evaluation of [(18) F]AlF-NOTA-G-TMTP1 for PET imaging of high aggressive hepatocellular carcinoma [J].Contrast Media Mol Imaging, 2016, 11(4):262-271.
[6] 李業(yè)森, 張德良, 張現(xiàn)忠等, 18F-AlF-NOTA-G-TMTP1的合成及對(duì)高轉(zhuǎn)移潛能肝癌細(xì)胞荷瘤鼠的顯像研究[J].中華核醫(yī)學(xué)與分子影像雜志, 2015, 35 (5): 351-354.

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備注/Memo

備注/Memo:
基金項(xiàng)目：福建省自然科學(xué)基金資助項(xiàng)目(2020J011224)
更新日期/Last Update: 2022-10-15