80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]魏霖,鐘國(guó)棟.甲狀腺細(xì)胞學(xué)Bethesda-Ⅲ類結(jié)節(jié)中Galectin-3和Cyclin D1的表達(dá)及臨床意義[J].福建醫(yī)藥雜志,2022,44(05):11-14.
　WEI Lin,ZHONG Guodong.Expression and clinical significance of detecting Galectin-3 and Cyclin D1 in Bethesda Ⅲ nodules of thyroid cytology[J].FUJIAN MEDICAL JOURNAL,2022,44(05):11-14.
點(diǎn)擊復(fù)制

甲狀腺細(xì)胞學(xué)Bethesda-Ⅲ類結(jié)節(jié)中Galectin-3和Cyclin D1的表達(dá)及臨床意義()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年05期
頁(yè)碼:
11-14
欄目:
臨床研究
出版日期:
2022-10-15

文章信息/Info

Title:
Expression and clinical significance of detecting Galectin-3 and Cyclin D1 in Bethesda Ⅲ nodules of thyroid cytology
文章編號(hào):
1002-2600（2022）05-0011-04
作者:
魏霖; 鐘國(guó)棟
福建中醫(yī)藥大學(xué)附屬第二人民醫(yī)院病理科（福州 350001）
Author(s):
WEI Lin; ZHONG Guodong
Department of Pathology, the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
甲狀腺; 細(xì)針穿刺; 沉渣包埋; Galectin-3; Cyclin D1
Keywords:
thyroid; fine needle aspiration;  sediment embedding slice; Galectin-3; Cyclin D1
分類號(hào):
R736.1
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討半乳糖凝集素3(Galectin-3)、細(xì)胞周期蛋白D1(Cyclin D1) 在甲狀腺細(xì)胞學(xué)Bethesda-Ⅲ類結(jié)節(jié)中的表達(dá)及臨床意義。 方法 對(duì)128例細(xì)胞學(xué)診斷為Bethesda-Ⅲ類結(jié)節(jié)的細(xì)針穿刺標(biāo)本進(jìn)行沉渣包埋，應(yīng)用Envision法檢測(cè)Galectin-3、Cyclin D1在標(biāo)本中的表達(dá)情況。 結(jié)果 組織病理確診為甲狀腺乳頭狀癌(papillary thyroid carcinoma，PTC) 68例，良性病變60例，包括結(jié)節(jié)性甲狀腺腫45例、濾泡性腺瘤11例、淋巴細(xì)胞甲狀腺炎4例。在PTC中Galectin-3、Cyclin D1表達(dá)明顯高于良性病變，陽(yáng)性率分別為92.6%和89.7%，兩者差異具有統(tǒng)計(jì)學(xué)意義(P＜0.001)。兩者聯(lián)合檢測(cè)可以提高診斷的敏感性、特異性、準(zhǔn)確性，且在PTC與良性疾病中表達(dá)的差異具有統(tǒng)計(jì)學(xué)意義(P＜0.001）。 結(jié)論 聯(lián)合檢測(cè)Galectin-3和Cyclin D1有助于甲狀腺細(xì)胞學(xué)Ⅲ類結(jié)節(jié)的診斷與鑒別診斷，為臨床治療提供可靠的依據(jù)。
Abstract:
Objective To investigate the expression and clinical significance of Galectin-3 and Cyclin D1 in Bethesda-Ⅲ nodules of thyroid cytology. Methods A total of 128 specimens of fine needle aspiration with Bethesda-Ⅲ nodules of thyroid cytology were carried out of sediment embedding slice, and the expression of Galectin-3 and Cyclin D1 in the specimens was detected by Envision method.Results There were 68 cases of papillary thyroid carcinoma (PTC), and 60 cases of benign lesions, including 45 cases of nodular goiter, 11 cases of follicular adenoma, and 4 cases of lymphocytic thyroiditis. The expression of Galectin-3 and Cyclin D1 in PTC was significantly higher than that in benign lesion. The positive rates of Galectin-3 and Cyclin D1 were 92.6% and 89.7% respectively and the difference was statistically significant (P<0.001). The sensitivity, specificity and accuracy of the diagnosis were improved by the combination of the two tests, and the difference of combined expression between PTC and benign disease was statistically significant (P<0.001). Conclusion The combined detection of Galectin-3 and Cyclin D1 is helpful for the diagnosis and differential diagnosis of Bethesda-Ⅲ nodules of thyroid cytology, and provides reliable basis for clinical treatment.

參考文獻(xiàn)/References:

[1] Cantara S, Marzocchi C, Pilli T, et al.Molecular signature of indeterminate thyroid lesions: Current methods to improve Fine Needle Aspiration Cytology (FNAC) diagnosis[J].Int J Mol Sci,2017,18(4):775.
[2] 張永生，王萍萍，高萍，等.免疫組化技術(shù)在甲狀腺液基細(xì)胞學(xué)診斷為Ⅲ類-意義不明確細(xì)胞非典型病變中的應(yīng)用價(jià)值[J].現(xiàn)代腫瘤醫(yī)學(xué),2021,29(11):1875-1879.
[3] Cibas E S, Ali S Z.The 2017 Bethesda system for reporting thyroid cytopathology [J].Thyroid,2017,27(11):1341-1346.
[4] 黎三艷，陳虹，王行富，等.膀胱乳頭狀尿路上皮腫瘤中CD10和CK20的表達(dá)[J].臨床與實(shí)驗(yàn)病理學(xué)雜志,2016,32(10):1113-1117.
[5] Vaccarella S, Franceschi S, Bray F, et al.Worldwide thyroid-cancer epidemic? The increasing impact of over diagnosis[J].N Engl J Med,2016,375(7):614-617.
[6] Bray F, Ferlay J, Soerjomataram I, et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[7] Rossi E D, Raffaelli M, Zannoni G F, et al.Diagnostic efficacy of conventional as compared to liquid-based cytology in thyroid lesions: evaluation of 10,360 fine needle aspiration cytology cases[J].Acta Cytol,2009,53(6):659-666.
[8] Cibas E S, Ali S Z.The Bethesda system for reporting thyroid cytopathology[J].Thyroid,2009,19(11):1159-1165.
[9] 林建龍，鐘國(guó)棟，王鴻程，等.2386例甲狀腺細(xì)針穿刺液基細(xì)胞學(xué)病理診斷分析[J].診斷病理學(xué)雜志,2018,25(2):112-117.
[10] Bartolazzi A, Gasbarri A, Papotti M, et al.Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions[J].Lancet,2001,357(9269):1644-1650.
[11] Sapio M R, Guerra A, Posca D, et al.Combined analysis of galectin-3 and BRAFV600E improves the accuracy of fine-needle aspiration biopsy with cytological findings suspicious for papillary thyroid carcinoma[J].Endocr Relat Cancer,2007,14(4):1089-1097.
[12] Bryson P C, Shores C G, Hart C, et al.Immunohistochemical distinction of follicular thyroid adenomas and follicular carcinomas[J].Arch Otolaryngol Head Neck Surg,2008,134(6):581-586.
[13] Torregrossa L, Faviana P, Filice M E, et al.CXC chemokine receptor 4 immunodetection in the follicular variant of papillary thyroid carcinoma: comparison to galectin-3 and hector battifora mesothelial cell-1[J].Thyroid,2010,20(5):495-504.
[14] Zhang L, Krausz T, Demay R M.A pilot study of Galectin-3, HBME-1, and p27 triple immunostaining pattern for diagnosis of indeterminate thyroid nodules in cytology with correlation to histology[J].Appl Immunohistochem Mol Morphol,2015,23(7):481-490.
[15] Xin Y, Guan D, Meng K, et al.Diagnostic accuracy of CK-19, Galectin-3 and HBME-1 on papillary thyroid carcinoma: a meta-analysis [J].Int J Clin Exp Pathol,2017,10(8):8130-8140.
[16] Funasaka T, Raz A, Nangia-Makker P.Galectin-3 in angiogenesis and metastasis [J].Glycobiology,2014,24(10):886-891.
[17] 葉丹，章佳波，姚玲莉，等.CyclinD1、p27表達(dá)與甲狀腺微小乳頭狀癌中央?yún)^(qū)淋巴結(jié)轉(zhuǎn)移超聲特征的關(guān)系[J].臨床薈萃,2021,36(3):262-265.
[18] Khoo M L, Beasley N J, Ezzat S, et al.Overexpression of cyclin D1 and underexpression of p27 predict lymph node metastases in papillary thyroid carcinoma [J].J Clin Endocrinol Metab,2002,87(4):1814-1818.

更新日期/Last Update: 2022-10-15