80年代土耳其译制电影,80年代外国电影|80年代外国电影有哪些_80年代外国经典电影在线播放地址是多少？

[1]林曉露,梁瑋,黃小杰,等.泛癌癥分析SPOCK1基因的表達(dá)及預(yù)后評(píng)估[J].福建醫(yī)藥雜志,2022,44(04):11-16.
　LIN Xiaolu,LIANG Wei,HUANG Xiaojie,et al.Expression and prognostic evaluation of SPOCK1 gene in pan-cancer analysis[J].FUJIAN MEDICAL JOURNAL,2022,44(04):11-16.
點(diǎn)擊復(fù)制

泛癌癥分析SPOCK1基因的表達(dá)及預(yù)后評(píng)估()
分享到：

《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年04期
頁碼:
11-16
欄目:
臨床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Expression and prognostic evaluation of SPOCK1 gene in pan-cancer analysis
文章編號(hào):
1002-2600(2022)04-0011-06
作者:
林曉露; 梁瑋; 黃小杰; 楊士杰; 郭仙斌; 鄧萬銀1
福建醫(yī)科大學(xué)省立臨床醫(yī)學(xué)院 福建省立醫(yī)院消化內(nèi)鏡中心(福州 350001)
Author(s):
LIN Xiaolu;  LIANG Wei;  HUANG Xiaojie;  YANG Shijie;  GUO Xianbin;  DENG Wanyin
Department of Digestive Endoscopy, Fujian Provincial Hospital, Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350001, China
關(guān)鍵詞:
SPOCK1; 泛癌; 表達(dá); 預(yù)后
Keywords:
SPOCK1;  pan-cancer;  expression;  prognosis
分類號(hào):
R730
文獻(xiàn)標(biāo)志碼:
B
摘要:
目的 探討SPOCK1基因在泛癌中的診斷價(jià)值及腫瘤預(yù)后評(píng)估的作用。方法 通過基因型組織表達(dá)(GTEx)、癌癥細(xì)胞系百科全書(CCLE)及癌癥基因組圖譜(TCGA)在內(nèi)的多個(gè)數(shù)據(jù)庫,評(píng)估SPOCK1基因在泛癌分析中的表達(dá)模式,ROC曲線分析SPOCK1基因在泛癌中的診斷價(jià)值,Cox回歸及Kaplan-Meier分析在泛癌中SPOCK1基因表達(dá)與腫瘤預(yù)后的相關(guān)性。結(jié)果 多個(gè)數(shù)據(jù)庫的差異分析結(jié)果顯示SPOCK1的表達(dá)在泛癌中不一致的上調(diào)或下調(diào),表達(dá)模式存在內(nèi)在的差異。ROC曲線顯示SPOCK1在預(yù)測(cè)14種癌癥類型方面具有一定的準(zhǔn)確性(AUC>0.7),在預(yù)測(cè)宮頸鱗癌和腺癌、膽管癌和睪丸癌具有較高的準(zhǔn)確性(AUC>0.9)。生存分析則提示SPOCK1高表達(dá)與膀胱尿路上皮癌、乳腺浸潤癌、腎透明細(xì)胞癌、肺腺癌、胰腺癌、嗜鉻細(xì)胞瘤、副神經(jīng)節(jié)瘤、間皮瘤及前列腺癌的低存活率相關(guān)。結(jié)論 SPOCK1可能是泛癌診斷和預(yù)后的重要分子生物標(biāo)志物。
Abstract:
Objective To investigate the diagnostic value and prognosis of SPOCK1 gene in pan-cancer.Methods Through multiple databases including Genotype-Tissue Expression, Cancer Cell Line Encyclopedia and the Cancer Genome Atlas, the expression pattern and the diagnostic value of SPOCK1 gene in pan-cancer was evaluated, and the correlation between SPOCK1 gene expression and tumor prognosis was analyzed by Cox regression and Kaplan Meier.Results The difference analysis results of multiple databases showed that the expression of SPOCK1 was up-regulated or down-regulated inconsistently in pan-cancer, and there were internal differences in expression patterns.ROC curve showed that SPOCK1 had certain accuracy in predicting 14 cancer types(AUC>0.7), and had high accuracy in predicting cervical squamous cell carcinoma, adenocarcinoma, cholangiocarcinoma and testicular cancer(AUC > 0.9).Survival analysis showed that the high expression of SPOCK1 was associated with low survival rate in bladder urothelial carcinoma, invasive breast cancer, clear cell renal cell carcinoma, lung adenocarcinoma, pancreatic cancer, pheochromocytoma, paraganglioma, mesothelioma and prostate cancer.Conclusion SPOCK1 may be an important molecular biomarker for diagnosis and prognosis of pan-cancer.

參考文獻(xiàn)/References:

[1] Chien M H, Lin Y W, Wen Y C, et al.Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis[J].J Exp Clin Cancer Res, 2019, 38(1): 246.
[2] Wang Y M, Wang W, Qiu E.SPOCK1 promotes the growth of Osteosarcoma cells through mTOR-S6K signaling pathway[J].Biomed Pharmacother, 2017, 95: 564-570.
[3] Ye Z Q, Chen J, Hu X, et al.SPOCK1: a multi-domain proteoglycan at the crossroads of extracellular matrix remodeling and cancer development[J].Am J Cancer Res, 2020, 10(10): 3127-3137.
[4] Bonnet F, Périn J P, Charbonnier F, et al.Structure and cellular distribution of mouse brain testican.Association with the postsynaptic area of hippocampus pyramidal cells[J].J Biol Chem, 1996, 271(8): 4373-4380.
[5] Li J, Ke J, Fang J, et al.A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells[J].J Cell Biochem, 2020, 121(1): 743-754.
[6] Veenstra V L, Damhofer H, Waasdorp C, et al.Stromal SPOCK1 supports invasive pancreatic cancer growth[J].Mol Oncol, 2017, 11(8): 1050-1064.
[7] Chen D, Zhou H, Liu G, et al.SPOCK1 promotes the invasion and metastasis of gastric cancer through Slug-induced epithelial-mesenchymal transition[J].J Cell Mol Med, 2018, 22(2): 797-807.
[8] Gao Y, Yu M, Ma M, et al.SPOCK1 contributes to the third-generation EGFR tyrosine kinase inhibitors resistance in lung cancer[J].J Cell Biochem, 2019, 120(8): 12566-12573.
[9] Chen M L, Ho C J, Yeh C M, et al.High SPOCK1 Expression is Associated with Advanced Stage, T Value, and Gleason Grade in Prostate Cancer[J].Medicina(Kaunas), 2019, 55(7):343.
[10] Aran D, Sirota M, Butte A J.Systematic pan-cancer analysis of tumour purity[J].Nat Commun, 2015, 6: 8971.
[11] Deng M X, Peng L, Li J M, et al.PPP1R14B is a prognostic and immunological biomarker in pan-cancer[J].Front Genet, 2021, 12: 763561.
[12] Zhang J, Zhi X, Shi S, et al.SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer[J].Biochem Biophys Res Commun, 2017, 482(4): 870-876.
[13] Liu H X, Cao Y Y, Qu J Y.SPOCK1 promotes the proliferation and migration of colon cancer cells by regulating the NF-κB pathway and inducing EMT[J].Neoplasma, 2021, 68(4): 702-710.
[14] Song X P, Han P, Liu J M, et al.Up-regulation of SPOCK1 induces epithelial-mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma[J].J Mol Histol, 2015, 46(4-5): 347-356.
[15] Yu F B, Li G H, Gao J X, et al.SPOCK1 is upregulated in recurrent glioblastoma and contributes to metastasis and Temozolomide resistance[J].Cell Prolif, 2016, 49(2): 195-206.

備注/Memo

備注/Memo:
基金項(xiàng)目:福建省衛(wèi)生計(jì)生中青年骨干人才培養(yǎng)項(xiàng)目(2018-ZQN-11)
1 通信作者,Email:[email protected]
更新日期/Last Update: 2022-08-15