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[1]黃雪平,王明霞,江麗鳳,等.慢性乙型肝炎病毒感染患者血清sPD-1檢測的臨床意義[J].福建醫(yī)藥雜志,2022,44(03):8-11.
　HUANG Xueping,WANG Mingxia,JIANG Lifeng,et al.Detection and clinical significance of soluble programmed death factor-1 in patients with chronic viral hepatitis B[J].FUJIAN MEDICAL JOURNAL,2022,44(03):8-11.
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慢性乙型肝炎病毒感染患者血清sPD-1檢測的臨床意義()
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《福建醫(yī)藥雜志》[ISSN:1002-2600/CN:35-1071/R]

卷:
44
期數(shù):
2022年03期
頁碼:
8-11
欄目:
臨床研究
出版日期:
2022-06-15

文章信息/Info

Title:
Detection and clinical significance of soluble programmed death factor-1 in patients with chronic viral hepatitis B
文章編號:
1002-2600(2022)03-0008-04
作者:
黃雪平; 王明霞; 江麗鳳1; 陸玉萍; 林志輝2
福建醫(yī)科大學省立臨床醫(yī)學院 福建省立醫(yī)院消化內科(福州 350001)
Author(s):
HUANG Xueping;  WANG Mingxia;  JIANG Lifeng;  LU Yuping;  LIN Zhihui
Department of digestive internal medicine,Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou,Fujian 350001,China
關鍵詞:
可溶性程序性死亡因子-1;  乙型肝炎;  肝癌;  抗病毒
Keywords:
soluble programmed death factor-1;  hepatitis B;  hepatocellular carcinoma;  antiviral
分類號:
R512.6+2
文獻標志碼:
B
摘要:
目的 探討血清中可溶性程序性死亡因子-1(sPD-1)在慢性乙型肝炎病毒(HBV)感染患者中檢測的臨床意義。方法 選擇我院就診的慢性HBV感染非肝癌患者41例(慢性HBV感染組)和乙型肝炎性肝癌(HCC)患者59例(HCC組),采用ELISA技術檢測兩組血清sPD-1的水平。比較sPD-1在慢性HBV感染組和HCC組之間及HCC組肝癌手術前后差異,分析慢性HBV感染患者sPD-1水平與性別、年齡、抗病毒治療等因素的關系。結果 慢性HBV感染患者血清sPD-1為94.0(85.0,128.0)pg/mL,而乙型肝炎性肝癌患者血清sPD-1為28(9.0,44.5)pg/mL,差異有統(tǒng)計學意義(P<0.001)。sPD-1在肝癌與HBV感染非肝癌患者之間具有明顯鑒別作用,其截斷值為63 pg/mL(AUC:0.916,P<0.001)。肝癌患者sPD-1水平從切除前的106(43,120)pg/mL下降至切除后2天的91(34,100)pg/mL,差異有統(tǒng)計學意義(P<0.001)。慢性HBV感染抗病毒組sPD-1水平[(111.37±59.13)pg/mL]明顯低于未抗病毒組[(306.09±59.13)pg/mL],差異有統(tǒng)計學意義(P=0.025)。慢性HBV感染sPD-1水平與年齡呈負相關(r=-0.82,P<0.05),與性別等其他因素無明顯關聯(lián)(P>0.05)。結論 sPD-1在慢性HBV感染和肝癌的發(fā)生中可能發(fā)揮了一定的作用; 監(jiān)測血清sPD-1值,可能有助于預測乙型肝炎性肝癌的發(fā)生,對肝癌有鑒別診斷的價值。
Abstract:
Objective To investigate the clinical significance of serum soluble programmed death-1(sPD-1)detection in patients with chronic hepatitis B virus(HBV)infection. Methods A total of 41 patients with chronic HBV infection without liver cancer(chronic HBV infection group)and 59 patients with HBV-induced hepatic carcinoma(HCC group)who were treated in our hospital were selected, and the serum sPD-1 levels in the two groups were detected by ELISA. sPD-1 of chronic HBV infection group and HCC group, as well as that before and after surgery in HCC group were compared, and the relationship between sPD-1 level and gender, age, antiviral therapy and other factors in patients with chronic HBV infection was analyzed. Results The serum sPD-1 of patients with chronic HBV infection was 94.0(85.0, 128.0)pg/mL, while the serum sPD-1 of patients with HCC was 28(9.0, 44.5)pg/mL, the difference was statistically significant(P<0.001). sPD-1 has a distinct role in discriminating between HCC and HBV-infected non-HCC patients, with a cut-off value of 63 pg/mL(AUC: 0.916, P<0.001). The level of sPD-1 in patients with HCC decreased from 106(43,120)pg/mL before resection to 91(34,100)pg/mL two days after resection, and the difference was statistically significant(P<0.001). The level of sPD-1 in the antiviral group of chronic HBV infection(111.37±59.13)pg/mL〗 was significantly lower than that in the non-antiviral group(306.09±59.13)pg/mL, and the difference was statistically significant(P=0.025). The level of sPD-1 in chronic HBV infection was negatively correlated with age(r=-0.82, P<0.05), and had no significant correlation with other factors such as gender(P>0.05). Conclusion sPD-1 may play a certain role in the occurrence of chronic HBV infection and HCC. Monitoring serum sPD-1 value may help to predict the occurrence of HCC and has the value of differential diagnosis of HCC.

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備注/Memo

備注/Memo:
基金項目:福建醫(yī)科大學啟航基金(2016QH108)
1 中山大學附屬第五醫(yī)院醫(yī)保科; 2 通信作者,Email: [email protected]
更新日期/Last Update: 2022-06-15